Catalog No.
YHH33101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr24-Pro500
Predicted molecular weight
56.88 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q16647
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Hydroperoxy icosatetraenoate dehydratase, Prostacyclin synthase, Prostaglandin I2 synthase, CYP8, CYP8A1, PTGIS
Restoring Prostacyclin/PGI2-PTGIR signaling alleviates intestinal fibrosis in Crohn's disease via fibroblast-specific YAP/TAZ inhibition., PMID:40390655
Effects of increasing the dietary contents of metabolizable energy and protein during the peripartum period on mammary gland development in Sistani goats., PMID:40289192
Human prostacyclin and thromboxane synthases: Molecular interactions, regulation, and pharmacology., PMID:40222477
Altered structural and transporter-related gene expression patterns in the placenta play a role in fetal demise during Porcine reproductive and respiratory syndrome virus infection., PMID:40119254
Proteomic Alterations in Retinal Müller Glial Cells Lacking Interleukin-6 Receptor: A Comprehensive Analysis., PMID:39699914
Sustained caloric restriction potentiates insulin action by activating prostacyclin synthase., PMID:39420421
Prostaglandin-related genes are differentially expressed in equine endometrium with different biopsy grade, degrees of inflammation, and fibrosis., PMID:39089078
Prostacyclin Synthase Deficiency Leads to Exacerbation or Occurrence of Endothelium-Dependent Contraction and Causes Cardiovascular Disorders Mainly via the Non-TxA2 Prostanoids/TP Axis., PMID:39082135
Identification of several lncRNA-mRNA pairs associated with marbling trait between Nanyang and Angus cattle., PMID:39014336
Identification of Prostaglandin I2 Synthase Rare Variants in Patients With Williams Syndrome and Severe Peripheral Pulmonary Stenosis., PMID:38639351
Analysis and experimental validation of fatty acid metabolism-related genes prostacyclin synthase (PTGIS) in endometrial cancer., PMID:37796199
Validating the role of PTGIS gene in colorectal cancer by bioinformatics analysis and in vitro experiments., PMID:37779109
Key Molecules in Bladder Cancer Affect Patient Prognosis and Immunotherapy Efficacy: Further Exploration for CNTN1 and EMP1., PMID:37437228
Serum exosomal m6A demethylase FTO promotes gefitinib resistance in non-small cell lung cancer by up-regulating FLRT3, PTGIS and SIRPα expression., PMID:37330168
rRNA-Derived Small RNA rsRNA-28S Regulates the Chemoresistance of Prostate Cancer Cells by Targeting PTGIS., PMID:37258478
PTGIS May Be a Predictive Marker for Ovarian Cancer by Regulating Fatty Acid Metabolism., PMID:36785673
Effects of Lipid Metabolism-Related Genes PTGIS and HRASLS on Phenotype, Prognosis, and Tumor Immunity in Lung Squamous Cell Carcinoma., PMID:36703911
Identification and analysis of novel endometriosis biomarkers via integrative bioinformatics., PMID:36339397
LPS-induced PTGS2 manipulates the inflammatory response through trophoblast invasion in preeclampsia via NF-κB pathway., PMID:36327673
Whole Exome Sequencing of Patients With Heritable and Idiopathic Pulmonary Arterial Hypertension in Central Taiwan., PMID:35811711
Hypoxia-hindered methylation of PTGIS in endometrial stromal cells accelerates endometriosis progression by inducing CD16- NK-cell differentiation., PMID:35781537
Prostanoid Signaling in Cancers: Expression and Regulation Patterns of Enzymes and Receptors., PMID:35453789
Polymorphisms of COX/PEG2 pathway-related genes are associated with the risk of lung cancer: A case-control study in China., PMID:35430434
Expression of oxytocin receptors and oxytocin assisted electroejaculation in the domestic cat (Felis catus)., PMID:35044000
Absence of prostacyclin greatly relieves cyclophosphamide-induced cystitis and bladder pain in mice., PMID:34555210
MAPK and Notch-Mediated Effects of Meso-Xanthin F199 Compounds on Proliferative Activity and Apoptosis of Human Melanocytes in Three-Dimensional Culture., PMID:34337053
The prostaglandin pathway is activated in patients who fail medical therapy for benign prostatic hyperplasia with lower urinary tract symptoms., PMID:34288015
Reduced levels of prostaglandin I2 synthase: a distinctive feature of the cancer-free trichothiodystrophy., PMID:34155103
Alternative activation of macrophages by prostacyclin synthase ameliorates alcohol induced liver injury., PMID:34112940
Interactions between PDA-associated polymorphisms and genetic ancestry alter ductus arteriosus gene expression., PMID:33837257
Altered sphingolipid function in Alzheimer's disease; a gene regulatory network approach., PMID:33773368
A new insight into subinteractomes of functional antagonists: Thromboxane (CYP5A1) and prostacyclin (CYP8A1) synthases., PMID:33527589
Generation of an induced pluripotent stem cell line (PUMCHi006-A) derived from a patient with pulmonary arterial hypertension carrying heterozygous c.1339 G > A mutation in PTGIS gene., PMID:33221675
Prostaglandin I2 (PGI2) inhibits Brucella abortus internalization in macrophages via PGI2 receptor signaling, and its analogue affects immune response and disease outcome in mice., PMID:33091457
A Prognostic Model Based on Six Metabolism-Related Genes in Colorectal Cancer., PMID:32953885
Chondrogenic Predifferentiation Inhibits Vascular Endothelial Growth Factor Angiogenic Effect in Pericranium-Derived Spheroids., PMID:32640938
Laser capture microdissection coupled mass spectrometry (LCM-MS) for spatially resolved analysis of formalin-fixed and stained human lung tissues., PMID:32565759
Derivation of an induced pluripotent stem cell line (PUMCHi003-A) from a patient with pulmonary arterial hypertension carrying heterozygous mutation in PTGIS gene., PMID:32559633
Prognostic value of prostaglandin I2 synthase and its correlation with tumor-infiltrating immune cells in lung cancer, ovarian cancer, and gastric cancer., PMID:32463792
Blueberry-Derived Exosome-Like Nanoparticles Counter the Response to TNF-α-Induced Change on Gene Expression in EA.hy926 Cells., PMID:32397678
Identification of cancer stem cell characteristics in liver hepatocellular carcinoma by WGCNA analysis of transcriptome stemness index., PMID:32311840
Contribution of Splenic Resistance Arteries to Splanchnic Blood Overflow in Cirrhosis., PMID:32242304
Association of Rare PTGIS Variants With Susceptibility and Pulmonary Vascular Response in Patients With Idiopathic Pulmonary Arterial Hypertension., PMID:32236489
Identification of Novel Prognosis and Prediction Markers in Advanced Prostate Cancer Tissues Based on Quantitative Proteomics., PMID:32108042
Changes in global gene expression indicate disordered autophagy, apoptosis and inflammatory processes and downregulation of cytoskeletal signalling and neuronal development in patients with Niemann-Pick C disease., PMID:31927669
Affinity Isolation and Mass Spectrometry Identification of Prostacyclin Synthase (PTGIS) Subinteractome., PMID:31226805
Cytochrome P450 family members are associated with fast-growing hepatocellular carcinoma and patient survival: An integrated analysis of gene expression profiles., PMID:30971588
Divergent roles of prostacyclin and PGE2 in human tendinopathy., PMID:30867043
Differential Expression of Prostaglandin I2 Synthase Associated with Arachidonic Acid Pathway in the Oral Squamous Cell Carcinoma., PMID:30532780
Pyrrolizidine alkaloid-induced alterations of prostanoid synthesis in human endothelial cells., PMID:30465738
For research use only. Not for human or drug use.
