Catalog No.
YHH33001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg129-Asp329
Predicted molecular weight
25.50 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q16644
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
3pK, MAPKAPK-3, MAP kinase-activated protein kinase 3, MAPK-activated protein kinase 3, MAPKAP kinase 3, MK-3, MAPKAPK3, Chromosome 3p kinase, MAPKAP-K3
Genome-wide DNA methylation and transcriptome sequencing analyses of lens tissue in an age-related mouse cataract model., PMID:39883715
Polyphenol Profile and Antioxidant, Antityrosinase, and Anti-Melanogenesis Activities of Ethanol Extract of Bee Pollen., PMID:39770476
Ethylene thiourea exposure induces neurobehavioral toxicity in zebrafish by disrupting axon growth and neuromuscular junctions., PMID:37980000
Integrated Transcriptome and Molecular Docking to Identify the Hub Superimposed Attenuation Targets of Curcumin in Breast Cancer Cells., PMID:37569854
Comparison of Quantitative Mass Spectrometric Methods for Drug Target Identification by Thermal Proteome Profiling., PMID:37439223
Identification of key genes and pathways revealing the central regulatory mechanism of brain-derived glucagon-like peptide-1 on obesity using bioinformatics analysis., PMID:35992905
Combining Recombinase-Mediated Cassette Exchange Strategy with Quantitative Proteomic and Phosphoproteomic Analyses to Inspect Intracellular Functions of the Tumor Suppressor Galectin-4 in Colorectal Cancer Cells., PMID:35742860
Small Molecule Arranged Thermal Proximity Coaggregation (smarTPCA)-A Novel Approach to Characterize Protein-Protein Interactions in Living Cells by Similar Isothermal Dose-Responses., PMID:35628420
Proteomics and phosphoproteomics analysis of vitreous in idiopathic epiretinal membrane patients., PMID:35510950
Association between plasma proteome and childhood neurodevelopmental disorders: A two-sample Mendelian randomization analysis., PMID:35306338
Inhibition of translocator protein 18 kDa suppressed the progression of glioma via the ELAV-like RNA-binding protein 1/MAPK-activated protein kinase 3 axis., PMID:35285415
MAPK Activated Protein Kinase 3 Is a Prognostic-Related Biomarker and Associated With Immune Infiltrates in Glioma., PMID:34938665
Methylome-wide association study of antidepressant use in Generation Scotland and the Netherlands Twin Register implicates the innate immune system., PMID:34880450
Heat Shock Protein Beta 1 is a Prognostic Biomarker and Correlated with Immune Infiltrates in Hepatocellular Carcinoma., PMID:34531676
Autoantibodies in the diagnosis, prognosis, and prediction of colorectal cancer., PMID:34528528
Heat shock protein 27 activity is linked to endothelial barrier recovery after proinflammatory GPCR-induced disruption., PMID:34516752
Whole-Transcriptome Analysis of Yak and Cattle Heart Tissues Reveals Regulatory Pathways Associated With High-Altitude Adaptation., PMID:34093634
Integrated Transcriptomic and Epigenetic Study of PCOS: Impact of Map3k1 and Map1lc3a Promoter Methylation on Autophagy., PMID:33763111
IL-3 is essential for ICOS-L stabilization on mast cells, and sustains the IL-33-induced RORγt+ Treg generation via enhanced IL-6 induction., PMID:33427298
Genistein nanoformulation promotes selective apoptosis in oral squamous cell carcinoma through repression of 3PK-EZH2 signalling pathway., PMID:33113500
p38 MAPK signalling regulates cytokine production in IL-33 stimulated Type 2 Innate Lymphoid cells., PMID:32103032
Novel functions for 2-phenylbenzimidazole-5-sulphonic acid: Inhibition of ovarian cancer cell responses and tumour angiogenesis., PMID:31958895
Unconventional secretion of α-Crystallin B requires the Autophagic pathway and is controlled by phosphorylation of its serine 59 residue., PMID:31729431
The Role of TTP Phosphorylation in the Regulation of Inflammatory Cytokine Production by MK2/3., PMID:31527197
Novel Autoantibodies Related to Cell Death and DNA Repair Pathways in Systemic Lupus Erythematosus., PMID:31494269
Cooperative and distinct functions of MK2 and MK3 in the regulation of the macrophage transcriptional response to lipopolysaccharide., PMID:31363109
IL-33-activated murine mast cells control the dichotomy between RORγt+ and Helios+ Tregs via the MK2/3-mediated IL-6 production in vitro., PMID:31334837
Development of gene therapy with a cyclic adenosine monophosphate response element decoy oligodeoxynucleotide to prevent vascular intimal hyperplasia., PMID:31204215
Gene co-expression network analysis identifies the hub genes associated with immune functions for nocturnal hemodialysis in patients with end-stage renal disease., PMID:30212930
Differential regulation of cytokine and chemokine expression by MK2 and MK3 in airway smooth muscle cells., PMID:30205157
IL-33 regulates cytokine production and neutrophil recruitment via the p38 MAPK-activated kinases MK2/3., PMID:30171775
The p38-MK2/3 Module Is Critical for IL-33-Induced Signaling and Cytokine Production in Dendritic Cells., PMID:29288203
Pharmacological and genetic inhibition of downstream targets of p38 MAPK in experimental nephrotic syndrome., PMID:29187369
p38MAPK/MK2-dependent phosphorylation controls cytotoxic RIPK1 signalling in inflammation and infection., PMID:28920954
MK2/3 Are Pivotal for IL-33-Induced and Mast Cell-Dependent Leukocyte Recruitment and the Resulting Skin Inflammation., PMID:27694493
Martinique Crinkled Retinal Pigment Epitheliopathy: Clinical Stages and Pathophysiologic Insights., PMID:27474146
Does the MK2-dependent Production of TNFα Regulate mGluR-dependent Synaptic Plasticity?, PMID:27296641
Heterometallic titanium-gold complexes inhibit renal cancer cells in vitro and in vivo., PMID:27213034
Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer., PMID:26988419
A dominant mutation in MAPKAPK3, an actor of p38 signaling pathway, causes a new retinal dystrophy involving Bruch's membrane and retinal pigment epithelium., PMID:26744326
Treatment of Obese Insulin-Resistant Mice With an Allosteric MAPKAPK2/3 Inhibitor Lowers Blood Glucose and Improves Insulin Sensitivity., PMID:26068544
MK3 modulation affects BMI1-dependent and independent cell cycle check-points., PMID:25853770
The stress-responsive kinases MAPKAPK2/MAPKAPK3 activate starvation-induced autophagy through Beclin 1 phosphorylation., PMID:25693418
Theoretical analysis of the binding of potential inhibitors to protein kinases MK2 and MK3., PMID:25665652
Organometallic Titanocene-Gold Compounds as Potential Chemotherapeutics in Renal Cancer. Study of their Protein Kinase Inhibitory Properties., PMID:25435644
The MK2/3 cascade regulates AMPAR trafficking and cognitive flexibility., PMID:25134715
MAPKAP kinase 3 suppresses Ifng gene expression and attenuates NK cell cytotoxicity and Th1 CD4 T-cell development upon influenza A virus infection., PMID:24935968
Monitoring native p38α:MK2/3 complexes via trans delivery of an ATP acyl phosphate probe., PMID:24601623
Endoplasmic reticulum-associated ubiquitin-conjugating enzyme Ube2j1 is a novel substrate of MK2 (MAPKAP kinase-2) involved in MK2-mediated TNFα production., PMID:24020373
Cross talk between the Akt and p38α pathways in macrophages downstream of Toll-like receptor signaling., PMID:23979601
For research use only. Not for human or drug use.
