Catalog No.
YHH29001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr13-Glu490
Predicted molecular weight
54.66 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q16555
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Dihydropyrimidinase-related protein 2, N2A3, CRMP-2, DPYSL2, ULIP-2, ULIP2, Collapsin response mediator protein 2, Unc-33-like phosphoprotein 2, CRMP2, DRP-2
GluN2B-Derived Small Interfering Peptide (GluN2B-Sip) Protects Against Sevoflurane-Induced Neurotoxicity in Developing Rats., PMID:40501436
R and S enantiomers of CBD3063, a CaV2.2 N-type calcium channel modulator, alleviate capsaicin-induced inflammatory pain., PMID:40487899
Collapsin Response Mediator Protein 2 (CRMP2) Modulates Mitochondrial Oxidative Metabolism in Knock-In AD Mouse Model., PMID:40358171
Lacosamide Is a Novel Drug That Improves AGTPBP1 Knockout-Mediated Impairment of Neuronal and Dopaminergic Function., PMID:40347376
CRMP2 phosphorylation regulates polarization and spinal infiltration of CD4+ T lymphocytes, inhibits spinal glial activation, and arthritic pain., PMID:40258133
Unraveling the role of abnormal AMPK and CRMP-2 phosphorylation in developmental fluoride neurotoxicity: Implications for synaptic damage and neurological disorders., PMID:40239547
CRMP2 and its phosphorylation prevent axonal misrouting of the corticospinal tract., PMID:40199395
Expression analysis and possible functional roles of semaphorin/plexin/CRMP families in mouse pancreatic islets., PMID:40148522
Discovery and identification of semaphorin 4D as a bioindicator of high fracture incidence in type 2 diabetic mice with glucose control., PMID:40073972
CRMP2 in the hippocampus alleviates chronic stress-induced depressive-like behaviours in mice by affecting synaptic function., PMID:40020760
Gestational autoantibody exposure impacts early brain development in a rat model of MAR autism., PMID:39929953
Involvement of CRMP2 Phosphorylation in Amyloid Beta-induced Tau Phosphorylation of Hippocampal Neurons in Alzheimer's Disease Mouse Model., PMID:39891817
Isoaspartate formation and irreversible aggregation of collapsin response mediator protein 2: implications for the etiology of epilepsy and age-related cognitive decline., PMID:39719537
Edonerpic maleate prevents epileptic seizure during recovery from brain damage by balancing excitatory and inhibitory inputs., PMID:39712974
CRMP2 regulates mossy fiber sprouting and modulates microtubule dynamics in a pilocarpine induced rat model of epilepsy., PMID:39662792
Isoaspartate formation and irreversible aggregation of collapsin response mediator protein 2: implications for the etiology of epilepsy and age-related cognitive decline., PMID:39606475
Unraveling the Nexus: The Role of Collapsin Response Mediator Protein 2 Phosphorylation in Neurodegeneration and Neuroregeneration., PMID:39532785
Holographic Ultrasound Modulates Neural Activity in a 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Mouse Model of Parkinson's Disease., PMID:39507404
Aβ25-35-induced autophagy and apoptosis are prevented by the CRMP2-derived peptide ST2-104 (R9-CBD3) via a CaMKKβ/AMPK/mTOR signaling hub., PMID:39325788
Inhibition of CRMP2 Phosphorylation Suppresses Microglia Activation in the Retina and Optic Nerve and Promotes Optic Nerve Regeneration After Optic Nerve Injury., PMID:39266914
Uncoupling the CRMP2-CaV2.2 Interaction Reduces Pain-Like Behavior in a Preclinical Joint-Pain Model., PMID:39233208
Small molecule targeting Na V 1.7 via inhibition of CRMP2-Ubc9 interaction reduces pain-related outcomes in a rodent osteoarthritic model., PMID:39106443
Molecular Signatures of Neurodegenerative Diseases Identified by Proteomic and Phosphoproteomic Analyses in Aging Mouse Brain., PMID:39069073
Peptide and Peptidomimetic Inhibitors Targeting the Interaction of Collapsin Response Mediator Protein 2 with the N-Type Calcium Channel for Pain Relief., PMID:39022365
Anti-CRMP2 antibody induces anxiety-like behavior and increases pyramidal neuron excitability in mice., PMID:38986818
Effects of esketamine on depression-like behavior and dendritic spine plasticity in the prefrontal cortex neurons of spared nerve injury-induced depressed mice., PMID:38985082
Uncoupling the CRMP2-CaV2.2 interaction reduces pain-like behavior in a preclinical osteoarthritis model., PMID:38895294
Clinical characteristics and genetic analysis of children with Omicron BF.7.14 type novel coronavirus-related acute necrotizing encephalopathy., PMID:38872817
Forebrain commissure formation in zebrafish embryo requires the binding of KLC1 to CRMP2., PMID:38830696
Inhibition of ERK1/2 or CRMP2 Disrupts Alcohol Memory Reconsolidation and Prevents Relapse in Rats., PMID:38791516
Inhibiting Nav1.7 channels in pulpitis: An in vivo study on neuronal hyperexcitability., PMID:38718567
Drug Treatment Attenuates Retinal Ganglion Cell Death by Inhibiting Collapsin Response Mediator Protein 2 Phosphorylation in Mouse Models of Normal Tension Glaucoma., PMID:38619671
Zinc Deficiency Decreases Neurite Extension via CRMP2 Signal Pathway., PMID:38583951
Quercetin attenuated ischemic stroke induced neurodegeneration by modulating glutamatergic and synaptic signaling pathways., PMID:38571617
Insular cortex stimulation alleviates neuropathic pain through changes in the expression of collapsin response mediator protein 2 involved in synaptic plasticity., PMID:38471625
Sinomenine ameliorates fibroblast-like synoviocytes dysfunction by promoting phosphorylation and nuclear translocation of CRMP2., PMID:38176664
A peptidomimetic modulator of the CaV2.2 N-type calcium channel for chronic pain., PMID:37972067
Effect of lidocaine on cognitively impaired rats: Anti-inflammatory and antioxidant mechanisms in combination with CRMP2 antiphosphorylation., PMID:37904712
Targeted transcriptional upregulation of SENP1 by CRISPR activation enhances deSUMOylation pathways to elicit antinociception in the spinal nerve ligation model of neuropathic pain., PMID:37862053
Intranasal CRMP2-Ubc9 inhibitor regulates Na V 1.7 to alleviate trigeminal neuropathic pain., PMID:37751532
Acupuncture Improves Synaptic Plasticity of SAMP8 Mice through the RhoA/ROCK Pathway., PMID:37723951
New insight into protein glycosylation in the development of Alzheimer's disease., PMID:37626031
Intranasal CRMP2-Ubc9 Inhibitor Regulates Na V 1.7 to Alleviate Trigeminal Neuropathic Pain., PMID:37502910
Identification and targeting of a unique NaV1.7 domain driving chronic pain., PMID:37498871
DPYSL2/CRMP2 isoform B knockout in human iPSC-derived glutamatergic neurons confirms its role in mTOR signaling and neurodevelopmental disorders., PMID:37479784
CRMP2 conditional knockout changes axonal function and ultrastructure of axons in mice corpus callosum., PMID:37479154
Elraglusib (formerly 9-ING-41) possesses potent anti-lymphoma properties which cannot be attributed to GSK3 inhibition., PMID:37316860
Indolyl-chalcone derivatives trigger apoptosis in cisplatin-resistant mesothelioma cells through aberrant tubulin polymerization and deregulation of microtubule-associated proteins., PMID:37305581
Ferulic acid as a therapeutic agent in depression: Evidence from preclinical studies., PMID:37183361
CRMP2 Participates in Regulating Mitochondrial Morphology and Motility in Alzheimer's Disease., PMID:37174687
For research use only. Not for human or drug use.
