Catalog No.
YHH27001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu67-Ile312
Predicted molecular weight
30.25 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q16513
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PRK2, PKN gamma, PRKCL2, Protein kinase C-like 2, Serine/threonine-protein kinase N2, PKN2, Protein-kinase C-related kinase 2
PKN2 Inhibits VEGFA and bFGF-Mediated Angiogenesis by Targeting HIF-1α in Colon Cancer., PMID:40515512
Identification and validation of pyroptosis-related genes in Alzheimer's disease based on multi-transcriptome and machine learning., PMID:40438507
Identifcation of the FGF family as therapeutic targets and prognostic biomarkers in the microenvironment of head and neck squamous cell carcinoma., PMID:40086631
Effect of the CSFV NS5A protein on key proteins in the MAPK and PI3K-mTOR signaling pathways in porcine macrophages., PMID:40078537
PKN2 enhances the immunosuppressive activity of polymorphonuclear myeloid-derived suppressor cells in esophageal carcinoma by mediating fatty acid oxidation., PMID:40069590
Illuminating understudied kinases: a generalizable biosensor development method applied to protein kinase N., PMID:39843538
PKN2 Promotes Peripheral Nerve Repair by Regulating Autophagy via Activation of the AKT-mTOR Pathway: An In Vitro Study., PMID:39575558
PKN2 Is a Dependency of the Mesenchymal-like Cancer Cell State., PMID:39560431
Molecular insights into the regulatory landscape of PKC-related kinase-2 (PRK2/PKN2) using targeted small compounds., PMID:39002682
Increased PKN2 and M2-Polarized Macrophages Promote HCT116 Cell Invasion., PMID:38505918
Deep sequencing of proteotoxicity modifier genes uncovers a Presenilin-2/beta-amyloid-actin genetic risk module shared among alpha-synucleinopathies., PMID:38496508
Integrative bioinformatics analysis of biomarkers and pathways for exploring the mechanisms and molecular targets associated with pyroptosis in type 2 diabetes mellitus., PMID:38034011
The fusiform gyrus exhibits differential gene-gene co-expression in Alzheimer's disease., PMID:37255536
SpkH (Sll0005) from Synechocystis sp. PCC 6803 is an active Mn2+-dependent Ser kinase., PMID:37209809
Phosphorylation of KRT8 (keratin 8) by excessive mechanical load-activated PKN (protein kinase N) impairs autophagosome initiation and contributes to disc degeneration., PMID:36897022
Phosphorylation-mediated PI3K-Art signalling pathway as a therapeutic mechanism in the hydrogen-induced alleviation of brain injury in septic mice., PMID:36308410
Target protein identification of andrographolide based on isomer approach., PMID:36279844
Protein Kinase N2 Reduces Hydrogen Peroxide-inducedDamage and Apoptosis in PC12 Cells by AntiOxidative Stress and Activation of the mTOR Pathway., PMID:36185087
Longitudinal lung function and gas transfer in individuals with idiopathic pulmonary fibrosis: a genome-wide association study., PMID:35985358
Genome-Wide Association Study for Idiopathic Ventricular Tachyarrhythmias Identifies Key Role of CCR7 and PKN2 in Calcium Homeostasis and Cardiac Rhythm Maintenance., PMID:35895078
Local synthesis of the phosphatidylinositol-3,4-bisphosphate lipid drives focal adhesion turnover., PMID:35809565
PKN2 deficiency leads both to prenatal 'congenital' cardiomyopathy and defective angiotensin II stress responses., PMID:35730579
Identification of novel off targets of baricitinib and tofacitinib by machine learning with a focus on thrombosis and viral infection., PMID:35551258
Discovery of new PKN2 inhibitory chemotypes via QSAR-guided selection of docking-based pharmacophores., PMID:35507210
The genomic signatures of natural selection in admixed human populations., PMID:35259336
Development of dihydropyrrolopyridinone-based PKN2/PRK2 chemical tools to enable drug discovery., PMID:35104640
Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion., PMID:35081338
Overexpression of PAX8-AS1 Inhibits Malignant Phenotypes of Papillary Thyroid Carcinoma Cells via miR-96-5p/PKN2 Axis., PMID:34745257
Protein kinase N2 connects blood flow with NO production in a double AKT., PMID:34720094
Upregulation of SNTB1 correlates with poor prognosis and promotes cell growth by negative regulating PKN2 in colorectal cancer., PMID:34663329
Phosphorylation-Mediated Molecular Pathway Changes in Human Pituitary Neuroendocrine Tumors Identified by Quantitative Phosphoproteomics., PMID:34571875
Protein kinase N2 mediates flow-induced endothelial NOS activation and vascular tone regulation., PMID:34499618
LINC00668 cooperated with HuR dependent upregulation of PKN2 to facilitate gastric cancer metastasis., PMID:33879018
MiR-452-5p promotes colorectal cancer progression by regulating an ERK/MAPK positive feedback loop., PMID:33658394
Inflammation and regulatory T cell genes are differentially expressed in peripheral blood mononuclear cells of Parkinson's disease patients., PMID:33504893
PKN2 is involved in aggregation and spheroid formation of fibroblasts in suspension culture by regulating cell motility and N-cadherin expression., PMID:33437883
circ_SEPT9, a newly identified circular RNA, promotes oral squamous cell carcinoma progression through miR-1225/PKN2 axis., PMID:33090705
The Mammalian Crumbs Complex Defines a Distinct Polarity Domain Apical of Epithelial Tight Junctions., PMID:32531288
Phosphorylation Sites in Protein Kinases and Phosphatases Regulated by Formyl Peptide Receptor 2 Signaling., PMID:32471307
Development of 2-(4-pyridyl)-benzimidazoles as PKN2 chemical tools to probe cancer., PMID:32085971
Genetic Contributions to Maternal and Neonatal Vitamin D Levels., PMID:32047095
Analysis of the microarray gene expression for breast cancer progression after the application modified logistic regression., PMID:31759986
Membrane Tension Orchestrates Rear Retraction in Matrix-Directed Cell Migration., PMID:31607653
Protein Kinase N Promotes Stress-Induced Cardiac Dysfunction Through Phosphorylation of Myocardin-Related Transcription Factor A and Disruption of Its Interaction With Actin., PMID:31564129
The Pyrin Inflammasome in Health and Disease., PMID:31456795
Protein kinase N controls a lysosomal lipid switch to facilitate nutrient signalling via mTORC1., PMID:31451768
A strategy for high-dimensional multivariable analysis classifies childhood asthma phenotypes from genetic, immunological, and environmental factors., PMID:30737985
Combinatorial Peptide Ligand Library-Based Photoaffinity Probe for the Identification of Phosphotyrosine-Binding Domain Proteins., PMID:30721620
Role of protein kinase N2 (PKN2) in cigarette smoke-mediated oncogenic transformation of oral cells., PMID:29480433
PKN2 in colon cancer cells inhibits M2 phenotype polarization of tumor-associated macrophages via regulating DUSP6-Erk1/2 pathway., PMID:29368606
For research use only. Not for human or drug use.
