Catalog No.
YHH22901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asn371-Pro746
Predicted molecular weight
69.53 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q15910
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ENX-1, Enhancer of zeste homolog 2, EZH2, Lysine N-methyltransferase 6, KMT6, Histone-lysine N-methyltransferase EZH2
EZH2 inhibition and 5-azacytidine enhance antitumor immunity in PTEN-deficient glioblastoma by activation viral mimicry response., PMID:40514071
EZH2 mutations increase the heterogeneity of chromatin states in lymphoma., PMID:40512686
Targeting G9a-m6A translational mechanism of SARS-CoV-2 pathogenesis for multifaceted therapeutics of COVID-19 and its sequalae., PMID:40510117
Mutant EZH2 alters the epigenetic network and increases epigenetic heterogeneity in B cell lymphoma., PMID:40504770
NeuID, a novel neuron-specific lncRNA, resolves a key epigenetic mechanism linking gene silencing to Alzheimer's disease., PMID:40501786
DNA methylation patterns in breast cancer, paired benign tissue from ipsilateral and contralateral breast, and healthy controls., PMID:40500734
EZH2 expression is restricted to malignant salivary gland tumors., PMID:40498901
Involvement of ADAM17-dependent MUC1-CT activation in TGF-β-induced EZH2 expression in human lung fibroblasts and in ovalbumin-induced airway fibrosis in mice., PMID:40484037
The EZH2 selective inhibitor ZLD1039 attenuates UUO-induced renal fibrosis by suppressing YAP activation., PMID:40478495
Chromatin modifiers in neurodevelopment., PMID:40469903
Dual Targeting EZH2 and Histone Deacetylases in Human Uterine Sarcoma Cells Under Both 2D and 3D Culture Conditions., PMID:40464712
Dual Roles of EZH2 in Tumor Proliferation and Immune Evasion in Lung Squamous Cell Carcinoma: A Pathway to Novel Immunotherapeutic Approaches., PMID:40464249
Fibroblasts-specific p16INK4a exacerbates inflammageing-mediated post-infarction ventricular remodelling through interacting with STAT3 to regulate NLRP3 transcription., PMID:40462499
EZH-2 expression and prognostic significance in patients with low-grade non-Hodgkin lymphoma., PMID:40456891
Multi-omics and AI-driven immune subtyping to optimize neoantigen-based vaccines for colorectal cancer., PMID:40456769
Immunostaining for polycomb group protein EZH2 as a diagnostic tool to differentiate urothelial carcinoma in situ from benign lesions., PMID:40456417
Single-cell sequencing reveals shared clonal signatures in nonmalignant B and tumor cells in T-prolymphocytic leukemia., PMID:40453149
Multiplex gene editing models of del(7q) reveal combined CUX1 and EZH2 loss drives clonal expansion and drug resistance., PMID:40453147
EZH2 expression in corneal and conjunctival intraepithelial neoplasia and squamous cell carcinoma: a potential marker for diagnosis., PMID:40451935
Formation of polyploid giant cancer cells and the transformative role of human cytomegalovirus IE1 protein., PMID:40436261
Is There Any Difference in Stem Cell Population between Type I and Type II Endometrial Cancer? A Pilot Study., PMID:40433700
A Peptide Encoded by lncRNA HOXB-AS3 Promotes Cigarette Smoke-Induced Inflammation in Bronchial Epithelial Cells via EZH2-Mediated H3K27me3 Modification., PMID:40417409
A previously uncharacterized role of TAp73 in ferroptosis by modulating oxidative homeostasis in cervical cancer., PMID:40409453
A specific form of cPRC1 containing CBX4 is co-opted to mediate oncogenic gene repression in diffuse midline glioma., PMID:40403727
Design and synthesis of CDK9/EZH2 dual-target inhibitors to achieve synergistic antitumor effects., PMID:40403644
H3K27Me3 abundance is associated with a decreased barrier function of endothelial cells by directly silencing VE-cadherin expression., PMID:40398293
EZH2 in non-cancerous diseases: Expanding horizons., PMID:40383730
Polydatin sensitizes osteosarcoma cells to methotrexate through suppressing the H19/H3K27me3/H3K9me3 mediated folate metabolism regulatory axis., PMID:40381463
Non-steroidal mineralocorticoid receptor antagonist finerenone inhibits peritoneal fibrosis induced by high-glucose dialysate via regulating enhancer of zeste homolog 2 (EZH2) expression., PMID:40364455
GMP-like and MLP-like Subpopulations of Hematopoietic Stem and Progenitor Cells Harboring Mutated EZH2 and TP53 at Diagnosis Promote Acute Myeloid Leukemia Relapse: Data of Combined Molecular, Functional, and Genomic Single-Stem-Cell Analyses., PMID:40362463
Polyphyllin I induces ferritinophagy dependent ferroptosis through EZH2 and promotes anti-tumor immunity., PMID:40359690
De novo pure erythroid leukemia with rapid progression harboring EZH2 and TP53 frameshift mutations: A case Report., PMID:40355175
Let-7 restrains an epigenetic circuit in AT2 cells to prevent fibrogenic intermediates in pulmonary fibrosis., PMID:40348760
Discovery of Highly Potent and Selective EZH2 Covalent Inhibitors via Incorporating Basic Amines., PMID:40340349
EZH2 inhibition mitigates HIV immune evasion, reduces reservoir formation, and promotes skewing of CD8+ T cells toward less-exhausted phenotypes., PMID:40333189
Downregulation of EZH2 Promotes Renal Epithelial Cellular Senescence and Kidney Aging., PMID:40326780
Mechanisms and Therapeutic Implications of EZH2 in Nasal Diseases., PMID:40320483
Exploring secondary extramedullary myeloma disease: a five-predictor scoring system with spotlight on double-hit cytogenetics., PMID:40316968
EZH2, via an association with KDM2B, modulates osteogenic differentiation of root apical papillary stem cells., PMID:40308879
Dual targeting of EZH2 and PD-L1 in Burkitt's lymphoma enhances immune activation and induces apoptotic pathway., PMID:40308579
EZH2 regulatory roles in cancer immunity and immunotherapy., PMID:40306002
NF-κB-mediated enhancement of H3K27me3 through EZH2: a mechanism to suppress pyocyanin-induced autophagy in macrophages., PMID:40301947
Superior survival in diffuse large B cell lymphoma of the bone with immune rich tumor microenvironment., PMID:40301298
EZH2 inhibitor and Vismodegib synergistically inhibit the growth and metastasis of medulloblastoma., PMID:40299236
S-nitrosylation of EZH2 alters PRC2 assembly, methyltransferase activity, and EZH2 stability to maintain endothelial homeostasis., PMID:40289112
H3F3A K27M mutations drive a repressive transcriptome by modulating chromatin accessibility independent of H3K27me3 in Diffuse Midline Glioma., PMID:40287708
Validation of an LC-MS/MS Method for the Simultaneous Intracellular Quantification of the CDK4/6 Inhibitor Abemaciclib and the EZH2 Inhibitors GSK126 and Tazemetostat., PMID:40284428
Clinical-Genetic Approach to Conditions with Macrocephaly and ASD/Behaviour Abnormalities: Variants in PTEN and PPP2R5D Are the Most Recurrent Gene Mutations in a Patient-Oriented Diagnostic Strategy., PMID:40282429
BRD9 functions as a methylarginine reader to regulate AKT-EZH2 signaling., PMID:40279411
Enhancer of zeste homolog 1/2 dual inhibitor valemetostat outperforms enhancer of zeste homolog 2-selective inhibitors in reactivating latent HIV-1 reservoirs ex vivo., PMID:40276229
For research use only. Not for human or drug use.
