Catalog No.
YHH21001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg29-Met149
Predicted molecular weight
15.90 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q15828
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CST6, Cystatin-M, Cystatin-6, Cystatin-E
Cystatin 6 (CST6) and Legumain (LGMN) are potential mediators in the pathogenesis of preeclampsia., PMID:40234537
Proteomic Analysis of Aqueous Humor Identified Clinically Relevant Molecular Targets for Neovascular Complications in Diabetic Retinopathy., PMID:40118382
Distinct Urinary Proteome Changes Across Estimated Glomerular Filtration Rate Stages in a Cohort of Black South Africans., PMID:40004202
Exploring the oncogenic roles of T-box transcription factor TBX2 and its potential as a therapeutic target., PMID:39912718
Genetic interaction analysis of Candida glabrata transcription factors CST6 and UPC2A in the regulation of respiration and fluconazole susceptibility., PMID:39714155
Alleviating role of ketamine in breast cancer cell-induced osteoclastogenesis and tumor bone metastasis-induced bone cancer pain through an SRC/EGR1/CST6 axis., PMID:39695463
Plasma proteomics and carotid intima-media thickness in the UK biobank cohort., PMID:39416432
Manipulating host secreted protein gene expression: an indirect approach by HPV11/16 E6/E7 to suppress PBMC cytokine secretion., PMID:39095779
Cystatin M/E ameliorates bone resorption through increasing osteoclastic cell estrogen influx., PMID:38766009
Single-cell transcriptomics reveals the aggressive landscape of high-grade serous carcinoma and therapeutic targets in tumor microenvironment., PMID:38714290
Systematic review and bioinformatics analysis of plasma and serum extracellular vesicles proteome in type 2 diabetes., PMID:38356516
A study on the role of Taxifolin in inducing apoptosis of pancreatic cancer cells: screening results using weighted gene co-expression network analysis., PMID:38305809
BCMA- and CST6-specific CAR T cells lyse multiple myeloma cells and suppress murine osteolytic lesions., PMID:37883186
Novel CSF biomarkers for diagnosis and integrated analysis of neuropsychiatric systemic lupus erythematosus: based on antibody profiling., PMID:37684700
PCDH7 as the key gene related to the co-occurrence of sarcopenia and osteoporosis., PMID:37476411
IL5RA as an immunogenic cell death-related predictor in progression and therapeutic response of multiple myeloma., PMID:37236993
Proteomic profiling of cutaneous melanoma explains the aggressiveness of distant organ metastasis., PMID:37082900
Screening genes related to embryo implantation in Dazu black goats (Capra Hircus) by morphological and transcriptome analyses., PMID:36644826
A novel necroptosis-related gene index for predicting prognosis and a cold tumor immune microenvironment in stomach adenocarcinoma., PMID:36389725
Loss-of-function mutations in CST6 cause dry skin, desquamation and abnormal keratosis without hypotrichosis., PMID:36371786
CST6 suppresses osteolytic bone disease in multiple myeloma by blocking osteoclast differentiation., PMID:35881476
RNA-Sequencing based analysis of bovine endometrium during the maternal recognition of pregnancy., PMID:35799127
TBX2 acts as a potent transcriptional silencer of tumour suppressor genes through interaction with the CoREST complex to sustain the proliferation of breast cancers., PMID:35687133
Loss-of-Function ROX1 Mutations Suppress the Fluconazole Susceptibility of upc2AΔ Mutation in Candida glabrata, Implicating Additional Positive Regulators of Ergosterol Biosynthesis., PMID:34935446
CST6 protein and peptides inhibit breast cancer bone metastasis by suppressing CTSB activity and osteoclastogenesis., PMID:34815788
Cystatin M/E Variant Causes Autosomal Dominant Keratosis Follicularis Spinulosa Decalvans by Dysregulating Cathepsins L and V., PMID:34322157
Investigating proteome changes between primary and metastatic cutaneous squamous cell carcinoma using SWATH mass spectrometry., PMID:32651104
Candidate genes involved in the defunctionalization and refunctionalization of the urinary bladder induced by bladder anuria and reperfusion., PMID:32542707
Interleukin-17A suppresses granular layer formation in a 3-D human epidermis model through regulation of terminal differentiation genes., PMID:32020672
Measurement of Organ-Specific and Acute-Phase Blood Protein Levels in Early Lyme Disease., PMID:31618575
Investigation of the clinical significance and prospective molecular mechanisms of cystatin genes in patients with hepatitis B virus‑related hepatocellular carcinoma., PMID:31115549
Deficiency of the human cysteine protease inhibitor cystatin M/E causes hypotrichosis and dry skin., PMID:30425301
Structural and functional analysis of cystatin E reveals enzymologically relevant dimer and amyloid fibril states., PMID:29967063
Functional and genomic characterisation of a xenograft model system for the study of metastasis in triple-negative breast cancer., PMID:29720474
Correlation of Cystatin E/M with Clinicopathological Features and Prognosis in Triple-Negative Breast Cancer., PMID:29530995
Low-level internalization of cystatin E/M affects legumain activity and migration of melanoma cells., PMID:28630039
Cathepsin B as a potential cystatin M/E target in the mouse hair follicle., PMID:28596234
Glycosylation is important for legumain localization and processing to active forms but not for cystatin E/M inhibitory functions., PMID:28528272
CO2 sensing in fungi: at the heart of metabolic signaling., PMID:28493119
Lipid Signaling via Pkh1/2 Regulates Fungal CO2 Sensing through the Kinase Sch9., PMID:28143980
FABP1 and FABP3 Have High Predictive Values for Renal Replacement Therapy in Patients with Acute Kidney Injury., PMID:27355328
Genome-Wide Mapping of Binding Sites Reveals Multiple Biological Functions of the Transcription Factor Cst6p in Saccharomyces cerevisiae., PMID:27143390
Cystatin E/M Suppresses Tumor Cell Growth through Cytoplasmic Retention of NF-κB., PMID:27090639
Methylation profiling of 48 candidate genes in tumor and matched normal tissues from breast cancer patients., PMID:25636590
TBX2 represses CST6 resulting in uncontrolled legumain activity to sustain breast cancer proliferation: a novel cancer-selective target pathway with therapeutic opportunities., PMID:24742492
Proteomic analysis of uterine fluid during the pre-implantation period of pregnancy in cattle., PMID:24478148
Anti-proliferative activity of 25-hydroxyvitamin D3 in human prostate cells., PMID:24291609
Insights in progressive myoclonus epilepsy: HSP70 promotes cystatin B polymerization., PMID:24063889
Dysregulation of the epigenome in triple-negative breast cancers: basal-like and claudin-low breast cancers express aberrant DNA hypermethylation., PMID:24045095
Analysis of legumain and cystatin 6 expression at the maternal-fetal interface in pigs., PMID:23686917
For research use only. Not for human or drug use.
