Catalog No.
YHH18301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu189-Pro439
Predicted molecular weight
29.10 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q15750
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
MAP3K7IP1, TGF-beta-activated kinase 1-binding protein 1, TAK1-binding protein 1, TGF-beta-activated kinase 1 and MAP3K7-binding protein 1, Mitogen-activated protein kinase kinase kinase 7-interacting protein 1, TAB1
Hsa-miR-134-5p predicts cardiovascular risk in circulating mononuclear cells and improves angiogenic action of senescent endothelial progenitor cells., PMID:38957039
[Bioinformatics analysis and validation of the interaction between PML protein and TAB1 protein]., PMID:38293990
Molecular characterization, expression and functional analysis of TAK1, TAB1 and TAB2 in Nile tilapia (Oreochromis niloticus)., PMID:38184182
Down-regulated TAB1 suppresses the replication of Coxsackievirus B5 via activating the NF-κB pathways through interaction with viral 3D polymerase., PMID:38072991
Plant miRNA osa-miR172d-5p suppressed lung fibrosis by targeting Tab1., PMID:36746980
Hsa_circ_0021727 (circ-CD44) promotes ESCC progression by targeting miR-23b-5p to activate the TAB1/NFκB pathway., PMID:36609391
Chlamydia trachomatis antigen induces TLR4-TAB1-mediated inflammation, but not cell death, in maternal decidua cells., PMID:36495029
Tongguanteng injection reverses paclitaxel resistance via upregulation of TAB1 expression in ovarian cancer in vitro and in vivo., PMID:36126783
Palmatine alleviates LPS-induced acute lung injury via interfering the interaction of TAK1 and TAB1., PMID:35760111
The MIR100HG/miR-29a-3p/Tab1 axis modulates TGF-β1-induced fibrotic changes in type II alveolar epithelial cells BLM-caused lung fibrogenesis in mice., PMID:35472619
TAB1 binding induced p38α conformation change: an accelerated molecular dynamics simulation study., PMID:35441632
XIAP promotes melanoma growth by inducing tumour neutrophil infiltration., PMID:35437868
RNF207 exacerbates pathological cardiac hypertrophy via post-translational modification of TAB1., PMID:35352799
TAK1 of blunt snout bream promotes NF-κB activation via interaction with TAB1 in response to pathogenic bacteria., PMID:34923116
Maternal RNF114-mediated target substrate degradation regulates zygotic genome activation in mouse embryos., PMID:34104941
TRIM26 positively regulates the inflammatory immune response through K11-linked ubiquitination of TAB1., PMID:34017102
MicroRNA-211 regulates the expression of TAB1 and inhibits the NF-κB signaling pathway in lipopolysaccharide-induced endometritis., PMID:33984721
SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species., PMID:33372854
Virus-induced p38 MAPK activation facilitates viral infection., PMID:33204339
Myeloma cells self-promote migration by regulating TAB1-driven TIMP-1 expression in mesenchymal stem cells., PMID:33183761
TAB1 regulates glycolysis and activation of macrophages in diabetic nephropathy., PMID:33044562
A mouse model for functional dissection of TAB1 O-GlcNAcylation., PMID:32676538
Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1β-IL1R and p38α-TAB1 Complexes., PMID:32543856
Insights into the molecular pathogenesis of cardiospondylocarpofacial syndrome: MAP3K7 c.737-7A > G variant alters the TGFβ-mediated α-SMA cytoskeleton assembly and autophagy., PMID:32105826
The Effect of Maternal Diet with Fish Oil on Oxidative Stress and Inflammatory Response in Sow and New-Born Piglets., PMID:32082476
Reversible EMT and MET mediate amnion remodeling during pregnancy and labor., PMID:32047115
ΜicroRNA‑889 plays a suppressive role in cell proliferation and invasion by directly targeting TAB1 in non‑small cell lung cancer., PMID:31115539
Molecular characterization and expression of TAK-binding proteins (TAB1-3) in Larimichthys crocea infected by Vibrio parahemolyticus and LPS., PMID:31051196
Black carp TAB1 up-regulates TAK1/IRF7/IFN signaling during the antiviral innate immune activation., PMID:31002927
MiR-758-3p regulates papillary thyroid cancer cell proliferation and migration by targeting TAB1., PMID:30940308
G protein-coupled receptors activate p38 MAPK via a non-canonical TAB1-TAB2- and TAB1-TAB3-dependent pathway in endothelial cells., PMID:30760523
MicroRNA-134 deactivates hepatic stellate cells by targeting TGF-β activated kinase 1-binding protein 1., PMID:30645141
Dual-target MDM2/MDMX inhibitor increases the sensitization of doxorubicin and inhibits migration and invasion abilities of triple-negative breast cancer cells through activation of TAB1/TAK1/p38 MAPK pathway., PMID:30462562
High expression of Tob1 indicates poor survival outcome and promotes tumour progression via a Wnt positive feedback loop in colon cancer., PMID:30447686
Molecular cloning and functional characterization of TRAF6 and TAK1 in rainbow trout, Oncorhynchus mykiss., PMID:30391533
Molecular identification and expression analysis of TAB1 from orange-spotted grouper (Epinephelus coioides)., PMID:30248360
α-Synuclein disrupts the anti-inflammatory role of Drd2 via interfering β-arrestin2-TAB1 interaction in astrocytes., PMID:30200997
The TAB1-p38α complex aggravates myocardial injury and can be targeted by small molecules., PMID:30135318
Oxidative stress-induced TGF-beta/TAB1-mediated p38MAPK activation in human amnion epithelial cells., PMID:29893818
miR‑873 inhibits colorectal cancer cell proliferation by targeting TRAF5 and TAB1., PMID:29328486
The interaction of TAK1 and TAB1 enhances LPS-induced cytokine release via modulating NF-κB activation (Larimichthys crocea)., PMID:29325713
TAB1-Induced Autoactivation of p38α Mitogen-Activated Protein Kinase Is Crucially Dependent on Threonine 185., PMID:29229647
Recognition of a glycosylation substrate by the O-GlcNAc transferase TPR repeats., PMID:28659383
NF-κB1, c-Rel, and ELK1 inhibit miR-134 expression leading to TAB1 upregulation in paclitaxel-resistant human ovarian cancer., PMID:28206956
Beyond the MHC: A canine model of dermatomyositis shows a complex pattern of genetic risk involving novel loci., PMID:28158183
The E3 ubiquitin ligase RNF114 and TAB1 degradation are required for maternal-to-zygotic transition., PMID:28073917
Tripartite Motif 8 Contributes to Pathological Cardiac Hypertrophy Through Enhancing Transforming Growth Factor β-Activated Kinase 1-Dependent Signaling Pathways., PMID:27956576
Catalytic Promiscuity of O-GlcNAc Transferase Enables Unexpected Metabolic Engineering of Cytoplasmic Proteins with 2-Azido-2-deoxy-glucose., PMID:27935279
Rapid Activation of Transforming Growth Factor β-Activated Kinase 1 in Chondrocytes by Phosphorylation and K63 -Linked Polyubiquitination Upon Injury to Animal Articular Cartilage., PMID:27768832
TIPE2 (Tumor Necrosis Factor α-induced Protein 8-like 2) Is a Novel Negative Regulator of TAK1 Signal., PMID:27601471
For research use only. Not for human or drug use.
