Catalog No.
YHH06201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu130-Glu451
Predicted molecular weight
39.26 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q15306
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
IRF-4, NF-EM5, MUM1, LSIRF, IRF4, Multiple myeloma oncogene 1, Interferon regulatory factor 4, Lymphocyte-specific interferon regulatory factor
Integrated transcriptomic and microbiomic analyses reveal mechanisms of Decapod iridescent virus 1 resistance in Macrobrachium rosenbergii., PMID:40491929
Large B-cell Lymphoma With Interferon Regulatory Factor 4 Rearrangement Presenting as a Primary Central Nervous System Lymphoma in the Brain., PMID:40486473
Correction to: Essential role of interferon-regulatory factor 4 in regulating diabetogenic CD4+ T and innate immune cells in autoimmune diabetes in NOD mice., PMID:40471693
A viral circular RNA in Kaposi's sarcoma-associated herpesvirus modulates viral and host gene expression during latent and lytic replication., PMID:40452889
IRF4 contributes to chemoresistance in IGH::BCL2-positive diffuse large B-cell lymphomas by mediating BCL2-induced SOX9 expression., PMID:40356256
Identification and validation of programmed cell death related biomarkers for the treatment and prevention COVID-19., PMID:40300201
Allogeneic hematopoietic stem cell transplantation in a patient with combined immunodeficiency caused by IRF4 mutation., PMID:40274250
Iris Pigmented Lesions: Unraveling the Genetic Basis of Iris Freckles and Nevi., PMID:40261663
Interferon regulatory factor 4 mediates nonenzymatic IRE1 dependency in multiple myeloma cells., PMID:40215234
c-FOS Confers Stem Cell-like Features to Multiple Myeloma Cells in a Bone Marrow Microenvironment., PMID:40214428
Histone lactylation-augmented IRF4 is implicated in arsenite-induced liver fibrosis via modulating Th17 cell differentiation., PMID:40209842
IRF4-regulated transcriptional and functional heterogeneity of lung-resident CD11b+ cDC2 subsets during influenza virus infection., PMID:40209091
Inflammatory CD11c+ B Cells Induced by the TREM2 Signal Accelerate Sepsis Development., PMID:40207848
Role of IRF4 in mediating plasmablast differentiation in diffuse large B-cell lymphomas via mTORC1 pathway., PMID:40204935
Comprehensive analysis and validation of autophagy-related gene in rheumatoid arthritis., PMID:40181826
IRF4 as a molecular biomarker in pan-cancer through multiple omics integrative analysis., PMID:40176546
Artesunate Inhibits Neointimal Hyperplasia by Promoting IRF4 Associated Macrophage Polarization., PMID:40126336
Unveiling IRF4-steered regulation of context-dependent effector programs in CD4+ T cells under Th17- and Treg-skewing conditions., PMID:40067830
Insights into the transcriptional regulation of CD22 in B cell chronic lymphocytic leukemia., PMID:40054694
The significance of PAX5 in Merkel cell carcinoma., PMID:40034069
Activation of aryl hydrocarbon receptor attenuates intestinal inflammation by enhancing IRF4-mediated macrophage M2 polarization., PMID:39971258
Distinct plasmablast developmental intermediates produce graded expression of IgM secretory transcripts., PMID:39923238
Case Series: Large B-cell Lymphoma With IRF4 Rearrangement Involving the Lung and Tonsil in Two Different Patients., PMID:39897193
MAPK4 inhibits the early aberrant activation of B cells in rheumatoid arthritis by promoting the IRF4-SHIP1 signaling pathway., PMID:39863600
The role of exosomal hsa-miR-125b-5p and hsa-miR-320c as non-invasive biomarkers in high-radon areas of Kazakhstan., PMID:39819391
Design, synthesis and biological evaluation of bisnoralcohol derivatives as novel IRF4 inhibitors for the treatment of multiple myeloma., PMID:39788064
Association of B-Lineage Lymphoblastic Leukaemia Gene Polymorphisms with Poor Prognostic Features., PMID:39733427
Identification of transcriptional regulators and signaling pathways mediating postnatal rumen growth and functional maturation in cattle., PMID:39656757
Interleukin-2-secreting T helper cells promote extra-follicular B cell maturation via intrinsic regulation of a B cell mTOR-AKT-Blimp-1 axis., PMID:39612915
IRF4 regulates myeloid-derived suppressor cells expansion and function in Schistosoma japonicum-infected mice., PMID:39609883
METTL3 facilitates kidney injury through promoting IRF4-mediated plasma cell infiltration via an m6A-dependent manner in systemic lupus erythematosus., PMID:39501302
[Effect of JMJD3-IRF4 Signaling Pathway-Mediated Macrophage Polarization on the Malignant Biological Behavior of Multiple Myeloma Cells]., PMID:39479832
Integrative 3D genomics with multi-omics analysis and functional validation of genetic regulatory mechanisms of abdominal fat deposition in chickens., PMID:39468045
IRF4: A potential prognostic biomarker for immunotherapy in NSCLC., PMID:39437487
TBK1 is involved in M-CSF-induced macrophage polarization through mediating the IRF5/IRF4 axis., PMID:39434428
Essential role of interferon-regulatory factor 4 in regulating diabetogenic CD4+ T and innate immune cells in autoimmune diabetes in NOD mice., PMID:39432837
JunB is required for CD8+ T cell responses to acute infections., PMID:39425978
Low-grade follicular lymphoma with interferon regulatory factor-4 rearrangement: Expanding the spectrum of interferon regulatory factor-4-rearranged lymphomas., PMID:39415926
The discovery of the RCC1::IRF4 Fusion in CLL patients with t(1;6)(p35.3;p25.2) chromosomal translocation., PMID:39410709
The chromosomal translocation t(1;6)(p35.3;p25.2), recurrent in chronic lymphocytic leukaemia, leads to RCC1::IRF4 fusion., PMID:39406248
NOD2-mediated dual negative regulation of inflammatory responses triggered by TLRs in the gastrointestinal tract., PMID:39403381
Targeting Immunoproteasome in Polarized Macrophages Ameliorates Experimental Emphysema Via Activating NRF1/2-P62 Axis and Suppressing IRF4 Transcription., PMID:39356034
Selective Enhancer Gain-of-Function Deregulates MYC Expression in Multiple Myeloma., PMID:39312195
Interferon Regulatory Factor 4: An Alternative Marker for Plasma Cells in Daratumumab-Treated Patients With Multiple Myeloma., PMID:39267340
Correlation of Immunomodulatory Cytokines with Tumor Volume and Cerebrospinal Fluid in Vestibular Schwannoma Patients., PMID:39272860
SGLT2 inhibitor promotes ketogenesis to improve MASH by suppressing CD8+ T cell activation., PMID:39243758
The Increased Frequency of Type 1 Regulatory T (Tr1) Cells and the Altered Expression of Aryl Hydrocarbon Receptor (AHR) and Interferon Regulatory Factor-4 (IRF4) Genes in Type 1 Diabetes: A Case-Control Study., PMID:39211721
Clinicopathological and Molecular Characteristics of Rare EBV-associated Diffuse Large B-cell Lymphoma With IRF4 Rearrangement., PMID:39172106
Suppression of SENP3 enhances macrophage alternative activation by mediating IRF4 de-SUMOylation in ESCC progression., PMID:39123188
Swimming in cold water increases the browning process by diminishing the Myostatin pathway., PMID:39093510
For research use only. Not for human or drug use.
