Catalog No.
YHH03601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser31-Leu354
Predicted molecular weight
38.54 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q15165
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PON 2, Serum aryldialkylphosphatase 2, A-esterase 2, PON2, Aromatic esterase 2, Serum paraoxonase/arylesterase 2
Expression of carboxylesterase and paraoxonase in the placenta and their association with chlorpyrifos exposure during pregnancy., PMID:40359857
Xenobiotic metabolizing gene variants and the risk of male infertility - A systematic review, meta-analysis and in silico analysis., PMID:40271533
Investigation of the Molecular Mechanisms of Paraoxonase-2 Mediated Radiotherapy and Chemotherapy Resistance in Oral Squamous Cell Carcinoma., PMID:40134131
[Tissue and plasma proteomic signatures associated with the risk of gastric cancer]., PMID:40107780
Neuroprotective Effects of Myrtle Berry By-Product Extracts on 6-OHDA-Induced Cytotoxicity in PC12 Cells., PMID:39857422
Deepening Cisplatin sensitivity on Oral Squamous cell Carcinoma cell lines after PON2 knockdown: A FTIRM investigation., PMID:39805243
Differential expression of cardiometabolic and inflammation markers and signaling pathways between overweight/obese Qatari adults with high and low plasma salivary α-amylase activity., PMID:39411310
Identification of oxidative stress-related diagnostic markers and immune infiltration features for idiopathic pulmonary fibrosis by bibliometrics and bioinformatics., PMID:39165378
Placental Bioenergetics and Antioxidant Homeostasis in Maternal Obesity and Gestational Diabetes., PMID:39061926
FOXA1 Suppresses Endoplasmic Reticulum Stress, Oxidative Stress, and Neuronal Apoptosis in Parkinson's Disease by Activating PON2 Transcription., PMID:38935306
The Human Paraoxonase 2: An Optimized Procedure for Refolding and Stabilization Facilitates Enzyme Analyses and a Proteomics Approach., PMID:38893310
Paraoxonase-2 agonist vutiglabridin promotes autophagy activation and mitochondrial function to alleviate non-alcoholic steatohepatitis., PMID:38852992
Identification of Potential Biomarkers for Major Depressive Disorder: Based on Integrated Bioinformatics and Clinical Validation., PMID:38722514
Paraoxonase-2 shRNA-mediated gene silencing suppresses proliferation and migration, while promotes chemosensitivity in clear cell renal cell carcinoma cell lines., PMID:38706121
Polygenic markers of survival and longevity in the antioxidant genes PON1, PON2, MTHFR, MSRA, SOD1, NQO1, and CAT in a 20-year follow-up study in the population from the Volga-Ural region., PMID:38679184
Antiapoptotic PON2 expression and its clinical implications in locally advanced oral squamous cell carcinoma., PMID:38602182
Contribution of the Paraoxonase-2 Enzyme to Cancer Cell Metabolism and Phenotypes., PMID:38397445
Expression and role of FKBPL in lung adenocarcinoma., PMID:38164287
Signature of paraoxonases in the altered redox homeostasis in Alzheimer's disease., PMID:38142921
Unveiling the therapeutic potential of a mutated paraoxonase 2 in diabetic retinopathy: Defying glycation, mitigating oxidative stress, ER stress and inflammation., PMID:38141706
A whole exome sequencing study to identify rare variants in multiplex families with alcohol use disorder., PMID:37915799
Paraoxonase 2 Deficiency Causes Mitochondrial Dysfunction in Retinal Pigment Epithelial Cells and Retinal Degeneration in Mice., PMID:37891899
New insights into the cytotoxic effects of Thymus vulgaris essential oil on the human triple-negative breast cancer cell line MDA-MB-231., PMID:37775061
Age-associated sex difference in the expression of mitochondria-based redox sensitive proteins and effect of pioglitazone in nonhuman primate brain., PMID:37770961
Modulation of paraoxonase-2 in human dermal fibroblasts by UVA-induced oxidative stress: A new potential marker of skin photodamage., PMID:37717644
A multi-centre, double-blind, randomized, placebo-controlled trial to evaluate the effectiveness and safety of ramelteon for the prevention of postoperative delirium in elderly cancer patients: a study protocol for JORTC-PON2/J-SUPPORT2103/NCCH2103., PMID:37340766
Paraoxonase 2 (PON2) plays a limited role in murine lung tumorigenesis., PMID:37337025
Effect of Sphingomyelinase-Treated LDLs on HUVECs., PMID:36903354
PON2 ameliorates Ang II-induced cardiomyocyte injury by targeting the CANX/NOX4 signaling pathway., PMID:36840500
Macrophage Repolarization as a Therapeutic Strategy for Osteosarcoma., PMID:36769180
Capsazepine (CPZ) Inhibits TRPC6 Conductance and Is Protective in Adriamycin-Induced Nephropathy and Diabetic Glomerulopathy., PMID:36672207
Interactome of Paraoxonase PON2 Reveals New Pathways for Tumor Growth Regulation., PMID:36653584
Role Played by Paraoxonase-2 Enzyme in Cell Viability, Proliferation and Sensitivity to Chemotherapy of Oral Squamous Cell Carcinoma Cell Lines., PMID:36613780
Paraoxonase-2 contributes to promoting lipid metabolism and mitochondrial function via autophagy activation., PMID:36509805
An Oxidative Stress-Related Gene Signature in Granulosa Cells Is Associated with Ovarian Aging., PMID:36466095
Paraoxonase 2 (PON2) Deficiency Reproduces Lipid Alterations of Diabetic and Inflammatory Glomerular Disease and Affects TRPC6 Signaling., PMID:36429053
Trailing TRAIL Resistance in Human Breast Adenocarcinoma Cells with Trichostatin A and Zebularine., PMID:36380402
Presence, enzymatic activity, and subcellular localization of paraoxonases 1, 2, and 3 in human lung tissues., PMID:36336126
RHOA G17V induces T follicular helper cell specification and involves angioimmunoblastic T-cell lymphoma via upregulating the expression of PON2 through an NF-κB-dependent mechanism., PMID:36249275
PON2 mediates mitochondrial dysfunction in tracheal epithelial cells in response to a quorum sensing molecule N-(-3-oxododecanoyl)-l-homoserine lactone., PMID:36094147
Protective Effects of Pioglitazone on Cognitive Impairment and the Underlying Mechanisms: A Review of Literature., PMID:36068789
Chlorpyrifos and parathion regulate oxidative stress differentially through the expression of paraoxonase 2 in human neuroblastoma cell., PMID:36058312
Examining the role of paraoxonase 2 in the dopaminergic system of the mouse brain., PMID:36056313
The role of sex and ovarian hormones in hippocampal damage and cognitive deficits induced by chronic exposure to hypobaric hypoxia., PMID:36003965
Production of highly soluble native human paraoxonase 2 with potential anti-biofilm property., PMID:35856452
Expression of PON1, PON2, PON3 and MPO Genes in Patients with Depressive Disorders., PMID:35743392
CircHIPK3 prevents chondrocyte apoptosis and cartilage degradation by sponging miR-30a-3p and promoting PON2., PMID:35716032
HDL Structure., PMID:35575917
Paraoxonase 2 C311S single nucleotide polymorphism is associated with type C lesions in coronary atherosclerosis., PMID:35460610
Transcriptome analysis of thymic tissues from Chinese Partridge Shank chickens with or without Newcastle disease virus LaSota vaccine injection via high-throughput RNA sequencing., PMID:35403571
For research use only. Not for human or drug use.
