Catalog No.
YHH00401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala2-Glu248
Predicted molecular weight
29.56 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q15056
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
KIAA0038, EIF4H, WSCR1, WBSCR1, eIF-4H, Williams-Beuren syndrome chromosomal region 1 protein, Eukaryotic translation initiation factor 4H
Note
For research use only.
Small interfering RNAs that deplete the cellular translation factor eIF4H impede mRNA degradation by the virion host shutoff protein of herpes simplex virus., PMID:18448541
Interactions between eIF4AI and its accessory factors eIF4B and eIF4H., PMID:18719248
Topology and regulation of the human eIF4A/4G/4H helicase complex in translation initiation., PMID:19203580
Uncoupling stress granule assembly and translation initiation inhibition., PMID:19369421
The virion host shutoff endonuclease (UL41) of herpes simplex virus interacts with the cellular cap-binding complex eIF4F., PMID:20427534
drr-2 encodes an eIF4H that acts downstream of TOR in diet-restriction-induced longevity of C. elegans., PMID:20456299
An alternative splicing isoform of eukaryotic initiation factor 4H promotes tumorigenesis in vivo and is a potential therapeutic target for human cancer., PMID:20473909
[Proteomic study of retinoid acid resistant NB4R1 cells apoptosis induced by realgar]., PMID:21223730
mRNA helicases: the tacticians of translational control., PMID:21427765
Gene expression pattern in canine mammary osteosarcoma., PMID:21528706
Duplex unwinding and ATPase activities of the DEAD-box helicase eIF4A are coupled by eIF4G and eIF4B., PMID:21840318
Growth defects and impaired cognitive-behavioral abilities in mice with knockout for Eif4h, a gene located in the mouse homolog of the Williams-Beuren syndrome critical region., PMID:22234171
The eukaryotic initiation factor eIF4H facilitates loop-binding, repetitive RNA unwinding by the eIF4A DEAD-box helicase., PMID:22457067
A putative polypeptide N-acetylgalactosaminyltransferase/Williams-Beuren syndrome chromosome region 17 (WBSCR17) regulates lamellipodium formation and macropinocytosis., PMID:22787146
mRNA decay during herpes simplex virus (HSV) infections: mutations that affect translation of an mRNA influence the sites at which it is cleaved by the HSV virion host shutoff (Vhs) protein., PMID:23077305
Eukaryotic Initiation Factor 4H Is under Transcriptional Control of p65/NF-κB., PMID:23776612
RNA-Seq reveals spliceosome and proteasome genes as most consistent transcripts in human cancer cells., PMID:24069164
ABCA7 expression is associated with Alzheimer's disease polymorphism and disease status., PMID:24141082
SpliceVista, a tool for splice variant identification and visualization in shotgun proteomics data., PMID:24692640
Drosha promotes splicing of a pre-microRNA-like alternative exon., PMID:24786770
Single-molecule kinetics of the eukaryotic initiation factor 4AI upon RNA unwinding., PMID:24909782
Identification of the responsible proteins for increased selenium bioavailability in the brain of transgenic rats overexpressing selenoprotein M., PMID:25269742
A ribonucleoprotein complex protects the interleukin-6 mRNA from degradation by distinct herpesviral endonucleases., PMID:25965334
Key contribution of eIF4H-mediated translational control in tumor promotion., PMID:26498689
The pseudorabies virus vhs protein cleaves RNA containing an IRES sequence., PMID:26744129
Array CGH - A Powerful Tool in Molecular Diagnostic of Pathogenic Microdeletions - Williams-Beuren Syndrome - A Case Report., PMID:30568834
Overexpression of miR-519d in lung adenocarcinoma inhibits cell proliferation and invasion via the association of eIF4H., PMID:28351305
Fullerenes May Cause eIF Mediated Perturbation in Translational Machinery: Evidence from in-silico Analysis., PMID:28801366
Divergence in Morris Water Maze-Based Cognitive Performance under Chronic Stress Is Associated with the Hippocampal Whole Transcriptomic Modification in Mice., PMID:28912681
Comparative Proteomics of Dying and Surviving Cancer Cells Improves the Identification of Drug Targets and Sheds Light on Cell Life/Death Decisions., PMID:29572246
A bimodal switch in global protein translation coupled to eIF4H relocalisation during advancing cell-cell transmission of herpes simplex virus., PMID:30028874
Targetome analysis of chaperone-mediated autophagy in cancer cells., PMID:30821613
eIF4B and eIF4H mediate GR production from expanded G4C2 in a Drosophila model for C9orf72-associated ALS., PMID:31023341
The Organizing Principles of Eukaryotic Ribosome Recruitment., PMID:31220979
A transcriptomic study of Williams-Beuren syndrome associated genes in mouse embryonic stem cells., PMID:31695049
Combination of podophyllotoxin and rutin modulate radiation-induced alterations of jejunal proteome in mice., PMID:32167845
Transcriptome-based selection and validation of optimal house-keeping genes for skin research in goats (Capra hircus)., PMID:32682387
RNA binding motif protein 10 suppresses lung cancer progression by controlling alternative splicing of eukaryotic translation initiation factor 4H., PMID:33130397
High-throughput screening identifies histone deacetylase inhibitors that modulate GTF2I expression in 7q11.23 microduplication autism spectrum disorder patient-derived cortical neurons., PMID:33208191
A Profound Basic Characterization of eIFs in Gliomas: Identifying eIF3I and 4H as Potential Novel Target Candidates in Glioma Therapy., PMID:33807050
Toxicity of pathogenic ataxin-2 in Drosophila shows dependence on a pure CAG repeat sequence., PMID:34077532
Isobaric Tags for Relative and Absolute Quantitation Identification of Blood Proteins Relevant to Paroxetine Response in Patients With Major Depressive Disorder., PMID:35509884
Corrigendum: Isobaric Tags for Relative and Absolute Quantitation Identification of Blood Proteins Relevant to Paroxetine Response in Patients With Major Depressive Disorder., PMID:35873247
RNA helicase EIF4A1-mediated translation is essential for the GC response., PMID:38011999
PABP-driven secondary condensed phase within RSV inclusion bodies activates viral mRNAs for ribosomal recruitment., PMID:38072230
Risk model based on genes regulating the response of tumor cells to T-cell-mediated killing in esophageal squamous cell carcinoma., PMID:38305770
Autophagy-dependent splicing control directs translation toward inflammation during senescence., PMID:39510077
RAB3GAP2 dysregulation in adult T-cell leukemia/lymphoma (ATLL) compared to acute lymphoblastic leukemia (ALL): a molecular perspective., PMID:39838474
Autophagy-dependent changes in alternative splicing bias translation toward inflammation in senescent cells., PMID:39904318
A strategy for multimodal integration of transcriptomics, proteomics, and radiomics data for the prediction of recurrence in patients with IDH-mutant gliomas., PMID:40214613
For research use only. Not for human or drug use.
