Catalog No.
YHH00401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala2-Glu248
Predicted molecular weight
29.56 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q15056
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
KIAA0038, EIF4H, WSCR1, WBSCR1, eIF-4H, Williams-Beuren syndrome chromosomal region 1 protein, Eukaryotic translation initiation factor 4H
A strategy for multimodal integration of transcriptomics, proteomics, and radiomics data for the prediction of recurrence in patients with IDH-mutant gliomas., PMID:40214613
Autophagy-dependent changes in alternative splicing bias translation toward inflammation in senescent cells., PMID:39904318
RAB3GAP2 dysregulation in adult T-cell leukemia/lymphoma (ATLL) compared to acute lymphoblastic leukemia (ALL): a molecular perspective., PMID:39838474
Autophagy-dependent splicing control directs translation toward inflammation during senescence., PMID:39510077
Risk model based on genes regulating the response of tumor cells to T-cell-mediated killing in esophageal squamous cell carcinoma., PMID:38305770
PABP-driven secondary condensed phase within RSV inclusion bodies activates viral mRNAs for ribosomal recruitment., PMID:38072230
RNA helicase EIF4A1-mediated translation is essential for the GC response., PMID:38011999
Corrigendum: Isobaric Tags for Relative and Absolute Quantitation Identification of Blood Proteins Relevant to Paroxetine Response in Patients With Major Depressive Disorder., PMID:35873247
Isobaric Tags for Relative and Absolute Quantitation Identification of Blood Proteins Relevant to Paroxetine Response in Patients With Major Depressive Disorder., PMID:35509884
Toxicity of pathogenic ataxin-2 in Drosophila shows dependence on a pure CAG repeat sequence., PMID:34077532
A Profound Basic Characterization of eIFs in Gliomas: Identifying eIF3I and 4H as Potential Novel Target Candidates in Glioma Therapy., PMID:33807050
High-throughput screening identifies histone deacetylase inhibitors that modulate GTF2I expression in 7q11.23 microduplication autism spectrum disorder patient-derived cortical neurons., PMID:33208191
RNA binding motif protein 10 suppresses lung cancer progression by controlling alternative splicing of eukaryotic translation initiation factor 4H., PMID:33130397
Transcriptome-based selection and validation of optimal house-keeping genes for skin research in goats (Capra hircus)., PMID:32682387
Combination of podophyllotoxin and rutin modulate radiation-induced alterations of jejunal proteome in mice., PMID:32167845
A transcriptomic study of Williams-Beuren syndrome associated genes in mouse embryonic stem cells., PMID:31695049
The Organizing Principles of Eukaryotic Ribosome Recruitment., PMID:31220979
eIF4B and eIF4H mediate GR production from expanded G4C2 in a Drosophila model for C9orf72-associated ALS., PMID:31023341
Targetome analysis of chaperone-mediated autophagy in cancer cells., PMID:30821613
A bimodal switch in global protein translation coupled to eIF4H relocalisation during advancing cell-cell transmission of herpes simplex virus., PMID:30028874
Comparative Proteomics of Dying and Surviving Cancer Cells Improves the Identification of Drug Targets and Sheds Light on Cell Life/Death Decisions., PMID:29572246
Divergence in Morris Water Maze-Based Cognitive Performance under Chronic Stress Is Associated with the Hippocampal Whole Transcriptomic Modification in Mice., PMID:28912681
Fullerenes May Cause eIF Mediated Perturbation in Translational Machinery: Evidence from in-silico Analysis., PMID:28801366
Overexpression of miR-519d in lung adenocarcinoma inhibits cell proliferation and invasion via the association of eIF4H., PMID:28351305
Array CGH - A Powerful Tool in Molecular Diagnostic of Pathogenic Microdeletions - Williams-Beuren Syndrome - A Case Report., PMID:30568834
The pseudorabies virus vhs protein cleaves RNA containing an IRES sequence., PMID:26744129
Key contribution of eIF4H-mediated translational control in tumor promotion., PMID:26498689
A ribonucleoprotein complex protects the interleukin-6 mRNA from degradation by distinct herpesviral endonucleases., PMID:25965334
Identification of the responsible proteins for increased selenium bioavailability in the brain of transgenic rats overexpressing selenoprotein M., PMID:25269742
Single-molecule kinetics of the eukaryotic initiation factor 4AI upon RNA unwinding., PMID:24909782
Drosha promotes splicing of a pre-microRNA-like alternative exon., PMID:24786770
SpliceVista, a tool for splice variant identification and visualization in shotgun proteomics data., PMID:24692640
ABCA7 expression is associated with Alzheimer's disease polymorphism and disease status., PMID:24141082
RNA-Seq reveals spliceosome and proteasome genes as most consistent transcripts in human cancer cells., PMID:24069164
Eukaryotic Initiation Factor 4H Is under Transcriptional Control of p65/NF-κB., PMID:23776612
mRNA decay during herpes simplex virus (HSV) infections: mutations that affect translation of an mRNA influence the sites at which it is cleaved by the HSV virion host shutoff (Vhs) protein., PMID:23077305
A putative polypeptide N-acetylgalactosaminyltransferase/Williams-Beuren syndrome chromosome region 17 (WBSCR17) regulates lamellipodium formation and macropinocytosis., PMID:22787146
The eukaryotic initiation factor eIF4H facilitates loop-binding, repetitive RNA unwinding by the eIF4A DEAD-box helicase., PMID:22457067
Growth defects and impaired cognitive-behavioral abilities in mice with knockout for Eif4h, a gene located in the mouse homolog of the Williams-Beuren syndrome critical region., PMID:22234171
Duplex unwinding and ATPase activities of the DEAD-box helicase eIF4A are coupled by eIF4G and eIF4B., PMID:21840318
Gene expression pattern in canine mammary osteosarcoma., PMID:21528706
mRNA helicases: the tacticians of translational control., PMID:21427765
[Proteomic study of retinoid acid resistant NB4R1 cells apoptosis induced by realgar]., PMID:21223730
An alternative splicing isoform of eukaryotic initiation factor 4H promotes tumorigenesis in vivo and is a potential therapeutic target for human cancer., PMID:20473909
drr-2 encodes an eIF4H that acts downstream of TOR in diet-restriction-induced longevity of C. elegans., PMID:20456299
The virion host shutoff endonuclease (UL41) of herpes simplex virus interacts with the cellular cap-binding complex eIF4F., PMID:20427534
Uncoupling stress granule assembly and translation initiation inhibition., PMID:19369421
Topology and regulation of the human eIF4A/4G/4H helicase complex in translation initiation., PMID:19203580
Interactions between eIF4AI and its accessory factors eIF4B and eIF4H., PMID:18719248
Small interfering RNAs that deplete the cellular translation factor eIF4H impede mRNA degradation by the virion host shutoff protein of herpes simplex virus., PMID:18448541
For research use only. Not for human or drug use.
