Catalog No.
YHG99501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Ser350
Predicted molecular weight
41.76 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q15047
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
H3-K9-HMTase 4, ESET, SETDB1, SET domain bifurcated 1, Histone H3-K9 methyltransferase 4, KMT1E, KIAA0067, Lysine N-methyltransferase 1E, ERG-associated protein with SET domain, Histone-lysine N-methyltransferase SETDB1
Targeting Setdb1 in T cells induces transplant tolerance without compromising antitumor immunity., PMID:40374612
SETDB1 decline promotes the resistance to sorafenib via DRP1 phosphorylation-mediated mitochondrial dysfunction in HepG2 cells., PMID:40345011
Estrogen increases Setdb1 cytoplasmic localization to stabilize Serpinh1 and improve protein homeostasis in osteoblasts., PMID:40324678
Sirtuin 2 inhibitor AGK2 exerts antiviral effects by inducing epigenetic suppression of hepatitis B virus covalently closed circular DNA through recruitment of repressive histone lysine methyltransferases and reduction of cccDNA., PMID:40270769
SETDB1 recruits CBX3 to regulate the SIRT4/PTEN axis, inhibiting autophagy and promoting ischemia-reperfusion-induced kidney injury., PMID:40197868
Genome-wide transcriptional silencing and mRNA stabilization allow the coordinated expression of the meiotic program in mice., PMID:40103226
CD39 Contributes to the Ability of Cell Invasion in Heterogeneity of Colorectal Cancer., PMID:40052646
The SETDB1-PC4-UPF1 post-transcriptional machinery controls periodic degradation of CENPF mRNA and maintains mitotic progression., PMID:40016337
Potent and selective SETDB1 covalent negative allosteric modulator reduces methyltransferase activity in cells., PMID:39994194
CHAMP1 complex directs heterochromatin assembly and promotes homology-directed DNA repair., PMID:39962076
BRD1 deficiency affects SREBF1-related lipid metabolism through regulating H3K9ac/H3K9me3 transition to inhibit HCC progression., PMID:39962068
SETDB1 amplification in osteosarcomas: Insights from its role in healthy tissues and other cancer types., PMID:39945463
Patients with Irritable Bowel Syndrome Exhibit Aberrant Expression of Endogenous Retroviruses and SETDB1., PMID:39936987
EZH2-Mediated PHF10 Suppression Amplifies HMGB1/NF-κB Axis That Confers Chemotherapy Resistance in Cholangiocarcinoma., PMID:39904827
Histone lysine methyltransferases and their specific methylation marks show significant changes in mouse testes from young to older ages., PMID:39832035
p53-mediated regulation of LINE1 retrotransposon-derived R-loops., PMID:39828096
H3K9 post-translational modifications regulate epiblast/primitive endoderm specification in rabbit blastocysts., PMID:39800758
Tumor Intrinsic Immunogenicity Suppressor SETDB1 Worsens the Prognosis of Patients with Hepatocellular Carcinoma., PMID:39768193
Targeting SETDB1 in cancer and immune regulation: Potential therapeutic strategies in cancer., PMID:39764697
Histone methyltransferase SETDB1 safeguards mouse fetal hematopoiesis by suppressing activation of cryptic enhancers., PMID:39689172
RNA binding by Periphilin plays an essential role in initiating silencing by the HUSH complex., PMID:39658355
Structure and Methyl-lysine Binding Selectivity of the HUSH Complex Subunit MPP8., PMID:39638237
CBX7 inhibitors affect H3K9 methyltransferase-regulated gene repression in leukemic cells., PMID:39613290
The HUSH epigenetic repressor complex silences PML nuclear body-associated HSV-1 quiescent genomes., PMID:39589886
Setdb1 Loss Induces Type I Interferons and Immune Clearance of Melanoma., PMID:39589394
SETDB1 activity is globally directed by H3K14 acetylation via its Triple Tudor Domain., PMID:39540436
The Roles of H3K9me3 Writers, Readers, and Erasers in Cancer Immunotherapy., PMID:39519018
The HIF2α-dependent upregulation of SETDB1 facilitates hypoxia-induced functional and phenotypical changes of pulmonary microvascular endothelial cells., PMID:39495248
Stem cell activity-coupled suppression of endogenous retrovirus governs adult tissue regeneration., PMID:39476839
Enhanced Transcription of Human Endogenous Retroviruses and TRIM28 Downregulation in Patients with Inflammatory Bowel Disease., PMID:39459904
SETDB1 targeting SESN2 regulates mitochondrial damage and oxidative stress in renal ischemia-reperfusion injury., PMID:39443993
Wuzi Yanzong Decoction Ameliorates Oligoasthenozoospermia by Up-Regulating Methyltransferase and Increasing Spata, Bcl, and Pik3 Series Genes Methylation Level., PMID:39441614
H3K14ac facilitates the reinstallation of constitutive heterochromatin in Drosophila early embryos by engaging Eggless/SetDB1., PMID:39437264
AZD1775 synergizes with SLC7A11 inhibition to promote ferroptosis., PMID:39245684
SETDB1 suppresses NK cell-mediated immunosurveillance in acute myeloid leukemia with granulo-monocytic differentiation., PMID:39096901
Targeting Smurf1 to block PDK1-Akt signaling in KRAS-mutated colorectal cancer., PMID:39039255
The critical role of SETDB1-mediated CCND1/PI3K/AKT pathway via p53-RS di-methylation at K370 in the proliferation of WRL68 cells induced by nicotine., PMID:38971100
SETDB1 regulates short interspersed nuclear elements and chromatin loop organization in mouse neural precursor cells., PMID:38961490
Cell cycle length governs heterochromatin reprogramming during early development in non-mammalian vertebrates., PMID:38943003
SETDB1 deletion causes DNA demethylation and upregulation of multiple zinc-finger genes., PMID:38904842
Roles of the histone methyltransferase SET domain bifurcated 1 in epithelial cells during tooth development., PMID:38875772
Setdb1 protects genome integrity in murine muscle stem cells to allow for regenerative myogenesis and inflammation., PMID:38848717
Necroptosis contributes to the intestinal toxicity of deoxynivalenol and is mediated by methyltransferase SETDB1., PMID:38823098
Discovery of an efficacious KDM5B PROTAC degrader GT-653 up-regulating IFN response genes in prostate cancer., PMID:38749268
Betaine alleviates spermatogenic cells apoptosis of oligoasthenozoospermia rat model by up-regulating methyltransferases and affecting DNA methylation., PMID:38735196
SETDB1 modulates the TGFβ response in Duchenne muscular dystrophy myotubes., PMID:38691608
SETDB1, an H3K9-specific methyltransferase: An attractive epigenetic target to combat cancer., PMID:38614159
[Downregulation of SETDB1 suppresses epithelial mesenchymal transition and invasion and metastasis in oral cancer via SOX7 methylation]., PMID:38583021
LINC00115 promotes chemoresistant breast cancer stem-like cell stemness and metastasis through SETDB1/PLK3/HIF1α signaling., PMID:38520019
Morc1 reestablishes H3K9me3 heterochromatin on piRNA-targeted transposons in gonocytes., PMID:38502704
For research use only. Not for human or drug use.
