Catalog No.
YHG90201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser217-Asp479
Predicted molecular weight
32.31 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q14790
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CAP4, MCH5, FADD-homologous ICE/ced-3-like protease, FLICE, Apoptotic cysteine protease, MORT1-associated ced-3 homolog, MACH, FADD-like ICE, ICE-like apoptotic protease 5, CASP8, CASP-8, Caspase-8, Apoptotic protease Mch-5
The investigation of apoptosis-related genes in periodontitis., PMID:40355964
Mechanistic insights into elevated caspase-8 expression driving caspase-3 activation and Gasdermin E-dependent pyroptosis in Alzheimer's disease., PMID:40334809
Ruxolitinib Ameliorates Neuronal Pyroptosis in the Acute Phase of Intracerebral Hemorrhage through Inhibiting the Activation of Caspase-8., PMID:40286335
Evolutionary and Functional Analysis of Caspase-8 and ASC Interactions to Drive Lytic Cell Death, PANoptosis., PMID:40277230
Macrophage caspase-8 inhibition accelerates necrotic core expansion in atheroma plaque in mice., PMID:40264785
Novel insight of critical genes involved in breast cancer brain metastasis: evidence from a cross-tissue transcriptome association study and validation through external clinical cohorts., PMID:40241087
FLIPL permits apoptotic and inflammatory signaling and inhibits necroptosis in mice without Caspase-8 oligomerization., PMID:40203042
Polysome Profiling Proves Impaired IL-10 and Caspase-8 Translation in PBMCs of Hemodialysis Patients., PMID:40149873
A bacterial network of T3SS effectors counteracts host pro-inflammatory responses and cell death to promote infection., PMID:40128366
Semi-synthetic flavonoid derivatives from Boesenbergiarotunda induce extrinsic apoptosis pathway via Caspase-3 and Caspase-8 in HCT116 Colon Cancer cell lines., PMID:40096806
The cGAS-STING-related signature affects the prognosis of colorectal cancer through its regulation of multiple immune cells., PMID:40035384
Raver1 links Ripk1 RNA splicing to caspase-8-mediated pyroptotic cell death, inflammation, and pathogen resistance., PMID:39946533
CASP8 intronic expansion identified by poly-glycine-arginine pathology increases Alzheimer's disease risk., PMID:39937857
Identifying potential drug targets for seborrheic keratosis through druggable genome-wide Mendelian randomization and colocalization analysis., PMID:39918628
The roles of STAT1, CASP8, and MYD88 in the care of ischemic stroke., PMID:39854740
TNFAIP3-interacting protein 1 (ABIN-1) negatively regulates caspase-8/FADD-dependent pyroptosis., PMID:39827378
Relationship between apoptosis gene DNA methylation and fetal growth and development., PMID:39788353
Pharmacological targeting of caspase-8/c-FLIPL heterodimer enhances complex II assembly and elimination of pancreatic cancer cells., PMID:39753884
Targeting caspase-8: a new strategy for combating hepatocellular carcinoma., PMID:39726605
Association of CASP8 rs3834129 and CTGF rs6918698 genotypes with susceptibility to colorectal cancer in a Mexican population., PMID:39707786
Synthesis of platinum nanoparticles functionalized with glutamine and conjugated with thiosemicarbazone and their cytotoxic effects on MDA-MB-231 breast cancer cell line and evaluation of CASP-8 gene expression., PMID:39665983
Caspase-8-dependent autophagy regulates neutrophil infiltration in oral squamous cell carcinoma., PMID:39625985
Novel Variants in Medium and Low Penetrance Predisposing Genes in a Hungarian Malignant Melanoma Cohort With Increased Risk., PMID:39609110
Divergent roles of RIPK3 and MLKL in high-fat diet-induced obesity and MAFLD in mice., PMID:39532538
Reverse hierarchical DED assembly in the cFLIP-procaspase-8 and cFLIP-procaspase-8-FADD complexes., PMID:39419969
Dichloroacetate reduces cisplatin-induced apoptosis by inhibiting the JNK/14-3-3/Bax/caspase-9 pathway and suppressing caspase-8 activation via cFLIP in murine tubular cells., PMID:39414949
Genetically predicted Caspase 8 levels mediates the causal association between CD4+ T cell and breast cancer., PMID:39391306
High TNF and NF-κB Pathway Dependency Are Associated with AZD5582 Sensitivity in OSCC via CASP8-Dependent Apoptosis., PMID:39360810
Prognostic impact of caspase-8 mutation in oral cavity squamous cell carcinoma., PMID:39289898
Activation of the NLRP1B inflammasome by caspase-8., PMID:39289441
Analysis of the Dynamics of Cognitive Impairments and Expression of Caspase Cascade Genes in Preclinical Stages of Parkinsonism Modeled Using α-Synuclein Oligomers., PMID:39259467
Multi-regional genomic and transcriptomic characterization of a melanoma-associated oral cavity cancer provide evidence for CASP8 alteration-mediated field cancerization., PMID:39244622
Low Expression of CASP8 Could be a Prognostic Biomarker in Neuroblastoma Patients., PMID:39234689
Influenza A virus infection activates caspase-8 to enhance innate antiviral immunity by cleaving CYLD and blocking TAK1 and RIG-I deubiquitination., PMID:39158695
Reuterin promotes pyroptosis in hepatocellular cancer cells through mtDNA-mediated STING activation and caspase 8 expression., PMID:39153728
Classical apoptotic stimulus, staurosporine, induces lytic inflammatory cell death, PANoptosis., PMID:39151726
NatB Protects Procaspase-8 from UBR4-Mediated Degradation and Is Required for Full Induction of the Extrinsic Apoptosis Pathway., PMID:39099191
Investigation of the association between the CASP8rs1045485 and SOD2 rs4880 single nucleotide polymorphisms (SNPs) with breast cancer., PMID:39038402
c-FLIP facilitates ZIKV infection by mediating caspase-8/3-dependent apoptosis., PMID:39038037
Mycobacterium tuberculosis Utilizes Serine/Threonine Kinase PknF to Evade NLRP3 Inflammasome-driven Caspase-1 and RIPK3/Caspase-8 Activation in Murine Dendritic Cells., PMID:39018500
The mechanosensitive Piezo1 channel exacerbates myocardial ischaemia/reperfusion injury by activating caspase-8-mediated PANoptosis., PMID:39008937
Circulating inflammatory factors and risk causality associated with type 2 diabetic nephropathy: A Mendelian randomization and bioinformatics study., PMID:38996161
Caspase-8 activity mediates TNFα production and restricts Coxiella burnetii replication during murine macrophage infection., PMID:38837340
Inhibition of caspase-8 cascade restrains the osteoclastogenic fate of bone marrow cells., PMID:38833170
BECN1 regulates FADD/RIPK1/Caspase-8 complex formation via RIPK1 ubiquitination by downregulating OTUD1 in MI/R induced myocyte apoptosis., PMID:38744338
ZBP1-mediated apoptosis and inflammation exacerbate steatotic liver ischemia/reperfusion injury., PMID:38743492
Quercetin, a natural flavonoid, protects against hepatic ischemia-reperfusion injury via inhibiting Caspase-8/ASC dependent macrophage pyroptosis., PMID:38735388
Arginine methylation of caspase-8 controls life/death decisions in extrinsic apoptotic networks., PMID:38730267
Deciphering DED assembly mechanisms in FADD-procaspase-8-cFLIP complexes regulating apoptosis., PMID:38710704
Expression of RIPK1 and FADD are associated with chemosensitivity and survival in head and heck squamous cell carcinoma via tanshinone IIA-mediated modulation of the RIPK1-FADD-Caspase 8 complex., PMID:38695620
For research use only. Not for human or drug use.
