Catalog No.
YHG89801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met52-Trp234
Predicted molecular weight
22.70 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q14773
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
LW, Landsteiner-Wiener blood group glycoprotein, Intercellular adhesion molecule 4, ICAM4, ICAM-4, LW blood group protein, CD242
DNA methylation of ICAM4 and NOXO1 participate in the formation of uterine fibroids via regulating immune cell infiltration., PMID:38015525
Immunological Study of IFN-γ, ICAM-4, and Vitamin D3 Markers among Gastrointestinal Tumor Patients in Babylon Province, Iraq., PMID:36708580
Participation of selected soluble cell adhesion molecules and syndecans in formation and development of endometriosis., PMID:34263915
Human DC-SIGN and CD23 do not interact with human IgG., PMID:31292524
Valsartan impedes epinephrine-induced ICAM-4 activation on normal, sickle cell trait and sickle cell disease red blood cells., PMID:31083675
Molecular analysis of the ICAM4 gene in an autochthonous East African population., PMID:30790296
Disrupting the vicious cycle created by NOX activation in sickle erythrocytes exposed to hypoxia/reoxygenation prevents adhesion and vasoocclusion., PMID:30661992
Regulation of Active ICAM-4 on Normal and Sickle Cell Disease RBCs via AKAPs Is Revealed by AFM., PMID:28076805
Comparison of stranded and non-stranded RNA-seq transcriptome profiling and investigation of gene overlap., PMID:26334759
Erythroid Adhesion Molecules in Sickle Cell Anaemia Infants: Insights Into Early Pathophysiology., PMID:26137540
Gαs proteins activate p72(Syk) and p60-c-Src tyrosine kinases to mediate sickle red blood cell adhesion to endothelium via LW-αvβ3 and CD44-CD44 interactions., PMID:26007235
When is an anti-D antibody not an anti-D antibody?, PMID:25925731
Host ICAMs play a role in cell invasion by Mycobacterium tuberculosis and Plasmodium falciparum., PMID:25586702
Acid sphingomyelinase is activated in sickle cell erythrocytes and contributes to inflammatory microparticle generation in SCD., PMID:25075126
Genetic variation of the whole ICAM4 gene in Caucasians and African Americans., PMID:24673173
Autonomous control of terminal erythropoiesis via physical interactions among erythroid cells., PMID:23500644
In vitro generated Rh(null) red cells recapitulate the in vivo deficiency: a model for rare blood group phenotypes and erythroid membrane disorders., PMID:23417980
Influence of sublingual immunotherapy on the expression of Mac-1 integrin in neutrophils from asthmatic children., PMID:22836621
The LW blood group system: a review., PMID:22646069
Variation in the ICAM1-ICAM4-ICAM5 locus is associated with systemic lupus erythematosus susceptibility in multiple ancestries., PMID:22523428
Epinephrine modulates BCAM/Lu and ICAM-4 expression on the sickle cell trait red blood cell membrane., PMID:22404936
Erythrocyte plasma membrane-bound ERK1/2 activation promotes ICAM-4-mediated sickle red cell adhesion to endothelium., PMID:22147898
An overview about erythrocyte membrane., PMID:20134094
[Polymorphism of LW blood group gene in Chinese population]., PMID:18549656
Role and regulation of sickle red cell interactions with other cells: ICAM-4 and other adhesion receptors., PMID:18502676
Modulation of erythroid adhesion receptor expression by hydroxyurea in children with sickle cell disease., PMID:18322255
Importance of molecular studies on major blood groups--intercellular adhesion molecule-4, a blood group antigen involved in multiple cellular interactions., PMID:17997044
DCS-1, DCS-2, and DFV share amino acid substitutions at the extracellular RhD protein vestibule., PMID:17900276
Epinephrine-induced activation of LW-mediated sickle cell adhesion and vaso-occlusion in vivo., PMID:17609430
Increased adhesion to endothelial cells of erythrocytes from patients with polycythemia vera is mediated by laminin alpha5 chain and Lu/BCAM., PMID:17412890
Red-cell ICAM-4 is a ligand for the monocyte/macrophage integrin CD11c/CD18: characterization of the binding sites on ICAM-4., PMID:16985175
ICAM gene cluster SNPs and prostate cancer risk in African Americans., PMID:16733712
A transcriptional enhancer that directs telencephalon-specific transgene expression in mouse brain., PMID:16581979
LW protein: a promiscuous integrin receptor activated by adrenergic signaling., PMID:16564726
Large-scale association study identifies ICAM gene region as breast and prostate cancer susceptibility locus., PMID:15604251
Integrin receptor specificity for human red cell ICAM-4 ligand. Critical residues for alphaIIbeta3 binding., PMID:15355350
Epinephrine acts through erythroid signaling pathways to activate sickle cell adhesion to endothelium via LW-alphavbeta3 interactions., PMID:15308566
Identification of critical amino-acid residues on the erythroid intercellular adhesion molecule-4 (ICAM-4) mediating adhesion to alpha V integrins., PMID:14551135
Characterization of ICAM-4 binding to the I domains of the CD11a/CD18 and CD11b/CD18 leukocyte integrins., PMID:12694184
Red cell ICAM-4 is a novel ligand for platelet-activated alpha IIbbeta 3 integrin., PMID:12477717
Novel secreted isoform of adhesion molecule ICAM-4: potential regulator of membrane-associated ICAM-4 interactions., PMID:12406883
Intercellular adhesion molecule-4 binds alpha(4)beta(1) and alpha(V)-family integrins through novel integrin-binding mechanisms., PMID:11435317
Erythroid cell adhesion molecules Lutheran and LW in health and disease., PMID:10895261
Binding sites of leukocyte beta 2 integrins (LFA-1, Mac-1) on the human ICAM-4/LW blood group protein., PMID:10846180
The LWb blood group as a marker of prehistoric Baltic migrations and admixture., PMID:10364680
The intercellular adhesion molecule (ICAM) family of proteins. New members and novel functions., PMID:9638475
cDNA cloning and chromosomal localization of the human telencephalin and its distinctive interaction with lymphocyte function-associated antigen-1., PMID:8995416
Characterization of the gene encoding the human LW blood group protein in LW+ and LW- phenotypes., PMID:8639917
The red cell LW blood group protein is an intercellular adhesion molecule which binds to CD11/CD18 leukocyte integrins., PMID:8566017
Molecular basis and expression of the LWa/LWb blood group polymorphism., PMID:7632968
For research use only. Not for human or drug use.
