Catalog No.
YHG89701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser522-Thr814
Predicted molecular weight
33.80 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q14767
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
LTBP-2, LTBP3, LTBP2, C14orf141, Latent-transforming growth factor beta-binding protein 2
Inhibition of LTBP2 Suppresses High Glucose-Induced Proliferation, Fibrosis, and Inflammation in Glomerular Mesangial Cells by Disrupting the PI3K/Akt/NF-κB Pathway., PMID:40471644
LTBP2 variants in childhood glaucoma: Phenotypic expansion and clinical experience., PMID:40384769
A feasibility of computational drug screening for Fuchs endothelial corneal dystrophy., PMID:40287480
Comprehensive identification of dysregulated extracellular matrix molecules in the corneal endothelium of patients with Fuchs endothelial corneal dystrophy., PMID:40287463
Identification of unique biomarkers for proliferative diabetic retinopathy with tractional retinal detachment by proteomics profiling of vitreous humor., PMID:40251337
Targeting LTBP2 Derived from Cancer-Associated Fibroblasts Sensitizes Esophageal Squamous Cell Carcinoma to Chemotherapy., PMID:40245188
HIF-1α/LTBP2 axis activate HSCs to promote liver fibrosis by interacting with LOXL1 via the ERK pathway., PMID:40244455
Trbp inhibits cardiac fibrosis through TGF-β pathway-mediated cross-talk between cardiomyocytes and fibroblasts., PMID:40067137
Comprehensive bioinformatics analysis of hub genes in ischemic heart failure and atrial fibrillation., PMID:40066352
Unbiased CSF Proteomics in Patients With Idiopathic Normal Pressure Hydrocephalus to Identify Molecular Signatures and Candidate Biomarkers., PMID:39951680
Combined ADAMTS10 and ADAMTS17 inactivation exacerbates bone shortening and compromises extracellular matrix formation., PMID:39896540
Exome sequencing identifies existing and novel variants in a South African cohort presenting with anterior segment dysgenesis., PMID:39870121
Zonulopathies as Genetic Disorders of the Extracellular Matrix., PMID:39766898
LTBP2 silence suppresses glioblastoma proliferation and tumor growth of xenograft tumor mice through modulating JAK2/STAT2 signaling pathway., PMID:39752891
Dextromethorphan inhibits collagen and collagen-like cargo secretion to ameliorate lung fibrosis., PMID:39693409
Sodium Propionate Alleviates Atopic Dermatitis by Inhibiting Ferroptosis via Activation of LTBP2/FABP4 Signaling Pathway., PMID:39634285
Identification of fibrosis-associated biomarkers in heart failure and human cancers., PMID:39563337
Multi-modal analysis of human hepatic stellate cells identifies novel therapeutic targets for metabolic dysfunction-associated steatotic liver disease., PMID:39522884
Integrative analysis of whole genome bisulfite and transcriptome sequencing reveals the effect of sodium butyrate on DNA methylation in the differentiation of bovine skeletal muscle satellite cells., PMID:39521294
Trabecular Meshwork Abnormalities in a Model of Congenital Glaucoma Due to LTBP2 Mutation., PMID:39432401
Integrated bioinformatics analysis and experimental validation on malignant progression and immune cell infiltration of LTBP2 in gliomas., PMID:39390437
Potential Involvements of Cilia-Centrosomal Genes in Primary Congenital Glaucoma., PMID:39337513
Alterations in anterior lens capsule structure and LTBP-2 expression in primary angle-closure glaucoma., PMID:39317460
LTBP2 down-regulated FGF2 to repress vascular smooth muscle cell proliferation and vascular remodeling in a rat model of intracranial aneurysm., PMID:39288883
Targeted next-generation sequencing reveals the genetic mechanism of Chinese Marfan syndrome cohort with ocular manifestation., PMID:38958168
Matrisome Transcriptome Dynamics during Tissue Aging., PMID:38792614
Genotype-phenotype profile of global ASPH-associated ectopia lentis and clinical findings from a Chinese cohort., PMID:38788814
Autosomal Dominant Weill-Marchesani-Like Syndrome in a Chinese Family due to Novel Haplotypic Mutations in LTBP2., PMID:38772353
Exploring the Genetic Landscape of Childhood Glaucoma., PMID:38671671
Targeted plasma proteomic analysis uncovers a high-performance biomarker panel for early diagnosis of gastric cancer., PMID:38631604
Looking through the Glass: Microspherophakia with LTBP2 Mutation in Siblings., PMID:38613564
LTBP2 regulates cisplatin resistance in GC cells via activation of the NF-κB2/BCL3 pathway., PMID:38577985
A novel LTBP2 gene variant in a Turkish family with juvenile-onset open-angle glaucoma., PMID:38557215
Novel compound heterozygous variants in LTBP2 associated with relative anterior microphthalmos., PMID:38545692
Whole-Genome Resequencing of Ujimqin Sheep Identifies Genes Associated with Vertebral Number., PMID:38473062
SGLT2i improves kidney senescence by down-regulating the expression of LTBP2 in SAMP8 mice., PMID:38454800
Plasma proteomic profiles predict future dementia in healthy adults., PMID:38347190
Identification and phenotypic analysis of novel LTBP2 mutations in a Chinese cohort with congenital ectopia lentis., PMID:38222456
Clinical and Genetic Landscape of Ectopia Lentis Based on a Cohort of Patients From 156 Families., PMID:38190127
In vivo identification of angle dysgenesis and its relation to genetic markers associated with glaucoma using artificial intelligence., PMID:38146977
Proteomic and Phosphoproteomic Analysis of Right Ventricular Hypertrophy in the Pulmonary Hypertension Rat Model., PMID:38015796
Plasma LTBP2 as a potential biomarker in differential diagnosis of connective tissue disease-associated interstitial lung disease and idiopathic pulmonary fibrosis: a pilot study., PMID:37864077
Genome-wide association study using a single-step approach for teat number in Duroc, Landrace and Yorkshire pigs in Korea., PMID:37814452
Weill-Marchesani syndrome: natural history and genotype-phenotype correlations from 18 news cases and review of literature., PMID:37734846
Multi-organ phenotypes in mice lacking latent TGFβ binding protein 2 (LTBP2)., PMID:37688792
circWHSC1: A circular RNA piece in the human cancer puzzle., PMID:37549517
Characteristics and genotype-phenotype correlations in ADAMTS17 mutation-related Weill-Marchesani syndrome., PMID:37506754
Exclusion of previously described variant in LTBP2 for primary glaucoma in Australian Burmese cats., PMID:37499110
Aqueous Humor TGF-β2 and Its Association With Intraocular Pressure in a Naturally Occurring Large Animal Model of Glaucoma., PMID:37459065
Curcumin relieves arecoline-induced oral submucous fibrosis via inhibiting the LTBP2/NF-κB axis., PMID:37382472
For research use only. Not for human or drug use.
