Catalog No.
YHG78501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Val64-Gly236
Predicted molecular weight
22.12 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q14353
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
GAMT, Guanidinoacetate N-methyltransferase
Gene delivery of AGAT and GAMT boosts creatine levels in creatine transporter deficiency patient fibroblasts., PMID:40338959
Experience with gender affirming hormones and puberty blockers (gonadotropin releasing hormone agonist): a qualitative analysis of sexual function., PMID:40192463
GAMT facilitates tumor progression via inhibiting p53 in clear cell renal cell carcinoma., PMID:40176130
[Two cases of creatine deficiency syndrome caused by GAMT gene mutations and literature review]., PMID:40105081
Assessing Creatine-Related Gene Expression in Kidney Disease: Can Available Data Give Insights into an Old Discussion?, PMID:40004980
Effect of gestational age and fetal sex on metabolism of creatine by uteri, placentae, and fetuses of pigs†., PMID:39836382
A creatine efflux transporter in oligodendrocytes., PMID:39792585
Intratesticular creatine maintains spermatogenesis by defining tight junctions., PMID:39730393
Multi-omics analysis and longitudinal study of reprogramming by dietary creatine to endogenous metabolism in largemouth bass (Micropterus salmoides)., PMID:39638990
Gene ontology defines pre-post- hatch energy dynamics in the complexus muscle of broiler chickens., PMID:39633257
Spatial metabolomics highlights metabolic reprogramming in acute myeloid leukemia mice through creatine pathway., PMID:39525575
Establishing a Core Outcome Set for Creatine Transporter Deficiency and Guanidinoacetate Methyltransferase Deficiency., PMID:39371127
Evidence for metabolism of creatine by the conceptus, placenta, and uterus for production of adenosine triphosphate during conceptus development in pigs†., PMID:38836439
Integrated transcriptomics and metabolomics study of embryonic breast muscle of Jiaji ducks., PMID:38824564
ClinGen variant curation expert panel recommendations for classification of variants in GAMT, GATM and SLC6A8 for cerebral creatine deficiency syndromes., PMID:38452609
Role of a novel circRNA-CGNL1 in regulating pancreatic cancer progression via NUDT4-HDAC4-RUNX2-GAMT-mediated apoptosis., PMID:38297362
Evidence of an intracellular creatine-sensing mechanism that modulates creatine biosynthesis via AGAT expression in human HAP1 cells., PMID:38104212
Aspects of human uterine creatine metabolism during the menstrual cycle and at term pregnancy†., PMID:37602666
Evidence and Recommendation for Guanidinoacetate Methyltransferase Deficiency Newborn Screening., PMID:37465909
Fourteen cases of cerebral creatine deficiency syndrome in children: a cohort study in China., PMID:37305710
Creatine Deficiency Disorders: Phenotypes, Genotypes, Diagnosis, and Treatment Outcomes., PMID:36856349
Hepatic oleate regulates one-carbon metabolism during high carbohydrate feeding., PMID:36791500
Guanidinoacetate (GAA) is a potent GABAA receptor GABA mimetic: Implications for neurological disease pathology., PMID:36726215
Creatine metabolism at the uterine-conceptus interface during early gestation in sheep†., PMID:36054379
Influence of homoarginine on creatine accumulation and biosynthesis in the mouse., PMID:36017222
Guanidine acetic acid exhibited greater growth performance in younger (13-30 kg) than in older (30-50 kg) lambs under high-concentrate feedlotting pattern., PMID:35990281
Identification of Genes Predicting Poor Response of Trastuzumab in Human Epidermal Growth Factor Receptor 2 Positive Breast Cancer., PMID:35935587
Processing mechanism of guanidinoacetate in choroid plexus epithelial cells: conversion of guanidinoacetate to creatine via guanidinoacetate N-methyltransferase and monocarboxylate transporter 12-mediated creatine release into the CSF., PMID:35658878
Identification of novel variations in SLC6A8 and GAMT genes causing cerebral creatine deficiency syndrome., PMID:35588794
Creatine nitrate supplementation strengthens energy status and delays glycolysis of broiler muscle via inhibition of LKB1/AMPK pathway., PMID:35007932
Elastic net-based identification of GAMT as potential diagnostic marker for early-stage gastric cancer., PMID:34990904
Cerebral creatine deficiency disorders - A clinical, genetic and follow up study from India., PMID:34974949
Creatine metabolism in patients with urea cycle disorders., PMID:34471603
Intellectual Disability and Brain Creatine Deficit: Phenotyping of the Genetic Mouse Model for GAMT Deficiency., PMID:34440375
GATM and GAMT synthesize creatine locally throughout the mammalian body and within oligodendrocytes of the brain., PMID:34418357
Identification of candidate genomic regions for chicken egg number traits based on genome-wide association study., PMID:34376144
Prognostic Significance of KIF11 and KIF14 Expression in Pancreatic Adenocarcinoma., PMID:34208606
Phosphate Suppression of Arbuscular Mycorrhizal Symbiosis Involves Gibberellic Acid Signaling., PMID:34037236
Identification of Metabolic-Associated Genes for the Prediction of Colon and Rectal Adenocarcinoma., PMID:33833525
A new rat model of creatine transporter deficiency reveals behavioral disorder and altered brain metabolism., PMID:33452333
Cardiac expression and location of hexokinase changes in a mouse model of pure creatine deficiency., PMID:33337958
[Genetic analysis and treatment for an infant with cerebral creatine deficiency syndrome type 2]., PMID:32820516
Inhibition of myostatin prevents microgravity-induced loss of skeletal muscle mass and strength., PMID:32315311
Exploring the protective effects of schizandrol A in acute myocardial ischemia mice by comprehensive metabolomics profiling integrated with molecular mechanism studies., PMID:32123298
Age-Dependent Decline in Cardiac Function in Guanidinoacetate-N-Methyltransferase Knockout Mice., PMID:32038270
The Effects of Early-Onset Pre-Eclampsia on Placental Creatine Metabolism in the Third Trimester., PMID:31991880
Magnetic resonance imaging reveals specific anatomical changes in the brain of Agat- and Gamt-mice attributed to creatine depletion and guanidinoacetate alteration., PMID:31951021
Muscle phenotype of AGAT- and GAMT-deficient mice after simvastatin exposure., PMID:31853708
A novel mutation in two cousins with guanidinoacetate methyltransferase (GAMT) deficiency presented with autism., PMID:31559727
For research use only. Not for human or drug use.
