Catalog No.
YHG74101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ile11-Gln241
Predicted molecular weight
27.40 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q14183
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Double C2-like domain-containing protein alpha, Doc2-alpha, DOC2A, Doc2
Identification of Common Brain Protein and Genetic Loci Between Parkinson's Disease and Lewy Body Dementia., PMID:40202048
Nominating novel proteins for anxiety via integrating human brain proteomes and genome-wide association study., PMID:38697224
Synaptotagmin 7 docks synaptic vesicles to support facilitation and Doc2α-triggered asynchronous release., PMID:38536730
Identifying novel proteins for suicide attempt by integrating proteomes from brain and blood with genome-wide association data., PMID:38317018
Disease-linked mutations in Munc18-1 deplete synaptic Doc2., PMID:38242640
Dissecting the autism-associated 16p11.2 locus identifies multiple drivers in neuroanatomical phenotypes and unveils a male-specific role for the major vault protein., PMID:37968726
16p11.2 CNV gene Doc2α functions in neurodevelopment and social behaviors through interaction with Secretagogin., PMID:37354460
Trafficking proteins show limited differences in mobility across different postsynaptic spines., PMID:36718370
Down-Regulation of Double C2 Domain Alpha Promotes the Formation of Hyperplastic Nerve Fibers in Aganglionic Segments of Hirschsprung's Disease., PMID:36142117
Inhibition of Histamine Release from RBL-2H3 Cells by Zoledronate Did Not Affect Rab27a/Doc2a Interaction., PMID:34853276
DOC-2/DAB2 interactive protein destabilizes c-Myc to impair the growth and self-renewal of colon tumor-repopulating cells., PMID:34449943
Ca2+ sensor proteins in spontaneous release and synaptic plasticity: Limited contribution of Doc2c, rabphilin-3a and synaptotagmin 7 in hippocampal glutamatergic neurons., PMID:33753311
Loss of Doc2b does not influence transmission at Purkinje cell to deep nuclei synapses under physiological conditions., PMID:32347796
Doc2 Proteins Are Not Required for the Increased Spontaneous Release Rate in Synaptotagmin-1-Deficient Neurons., PMID:32098902
Doc2b Ca2+ binding site mutants enhance synaptic release at rest at the expense of sustained synaptic strength., PMID:31594980
Increased expression of DOC2A in human and rat temporal lobe epilepsy., PMID:30844661
Excitatory and Inhibitory Neurons Utilize Different Ca2+ Sensors and Sources to Regulate Spontaneous Release., PMID:29754754
Deep phenotyping of speech and language skills in individuals with 16p11.2 deletion., PMID:29445122
The 16p11.2 homologs fam57ba and doc2a generate certain brain and body phenotypes., PMID:28934389
Inhibition of the mevalonate pathway by simvastatin interferes with mast cell degranulation by disrupting the interaction between Rab27a and double C2 alpha proteins., PMID:28864210
Loss of Doc2-Dependent Spontaneous Neurotransmission Augments Glutamatergic Synaptic Strength., PMID:28539418
Phosphorylation of synaptotagmin-1 controls a post-priming step in PKC-dependent presynaptic plasticity., PMID:27091977
DOC2 isoforms play dual roles in insulin secretion and insulin-stimulated glucose uptake., PMID:25005332
DOC-2/DAB2 interacting protein status in high-risk prostate cancer correlates with outcome for patients treated with radiation therapy., PMID:24867541
Mutations that disrupt Ca²⁺-binding activity endow Doc2β with novel functional properties during synaptic transmission., PMID:24356452
Association of the variant rs2243421 of human DOC-2/DAB2 interactive protein gene (hDAB2IP) with gastric cancer in the Chinese Han population., PMID:23246699
[Function of SM protein in vesicle transport]., PMID:22522155
Doc2 is a Ca2+ sensor required for asynchronous neurotransmitter release., PMID:22036572
Role of the polybasic sequence in the Doc2alpha C2B domain in dense-core vesicle exocytosis in PC12 cells., PMID:20403080
DOC2B, C2 domains, and calcium: A tale of intricate interactions., PMID:20052564
Doc2 alpha and Munc13-4 regulate Ca(2+) -dependent secretory lysosome exocytosis in mast cells., PMID:18354201
DOC2A and DOC2B are sensors for neuronal activity with unique calcium-dependent and kinetic properties., PMID:16515538
Mucin secretion and PKC isoforms in SPOC1 goblet cells: differential activation by purinergic agonist and PMA., PMID:12588704
Doc2 alpha as modulator of Ca(2+)-dependent exocytosis., PMID:11210576
Doc2gamma, a third isoform of double C2 protein, lacking calcium-dependent phospholipid binding activity., PMID:11027523
Is double C2 protein (DOC2) expressed in bovine adrenal medulla? A commercial anti-DOC2 monoclonal antibody recognizes a major bovine mitochondrial antigen., PMID:10998344
Double C2 protein. A review., PMID:10865129
Different spatiotemporal expression of DOC2 genes in the developing rat brain argues for an additional, nonsynaptic role of DOC2B in early development., PMID:10651871
Doc2alpha is an activity-dependent modulator of excitatory synaptic transmission., PMID:10594652
Transient, phorbol ester-induced DOC2-Munc13 interactions in vivo., PMID:10488064
Presynaptic mechanism for phorbol ester-induced synaptic potentiation., PMID:10460232
Doc2 is not associated with known regulated exocytotic or endosomal compartments in adrenal chromaffin cells., PMID:10377260
Interaction of Doc2 with tctex-1, a light chain of cytoplasmic dynein. Implication in dynein-dependent vesicle transport., PMID:9804756
Role of the Doc2 alpha-Munc13-1 interaction in the neurotransmitter release process., PMID:9736751
Physical and functional interactions of Doc2 and Munc13 in Ca2+-dependent exocytotic machinery., PMID:9195900
DOC2 proteins in rat brain: complementary distribution and proposed function as vesicular adapter proteins in early stages of secretion., PMID:9115738
Molecular cloning of mouse Doc2alpha and distribution of its mRNA in adult mouse brain., PMID:9073161
Calcium-dependent phospholipid binding to the C2A domain of a ubiquitous form of double C2 protein (Doc2 beta)., PMID:8902635
Doc2 enhances Ca2+-dependent exocytosis from PC12 cells., PMID:8631736
Molecular cloning of an isoform of Doc2 having two C2-like domains., PMID:8554557
For research use only. Not for human or drug use.
