Catalog No.
YHG69001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Glu172
Predicted molecular weight
20.96 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q14011
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CIRBP, A18 hnRNP, CIRP, Glycine-rich RNA-binding protein CIRP, A18HNRNP, Cold-inducible RNA-binding protein
FGF21 alleviates α-II-spectrin breakdown in a model of oxygen-glucose deprivation and modulates global protein phosphorylation in hippocampal neurons., PMID:40447258
CIRBP regulates mitochondrial respiratory function and modulates neuronal developmental abnormalities induced by perinatal hypoxia., PMID:40441335
Identification of a multiple DAMP scavenger mimicking the DAMP-binding site of TLR4 to ameliorate lethal sepsis., PMID:40421030
Structural basis of phosphorylation-independent nuclear import of CIRBP by TNPO3., PMID:40360518
Extracellular Cold-Inducible RNA-Binding Protein: Progress from Discovery to Present., PMID:40332009
CIRBP mRNA level in breast cancer is associated with HIF1α gene expression and microvascular density., PMID:40320538
Effects of maternal blood beta-hydroxybutyrate on brown adipose tissue functions and thermogenic and metabolic health in neonatal calves., PMID:40222674
Role of cold-inducible RNA-binding protein in hypothalamic regulation of feeding behavior during fasting and cold exposure., PMID:40112768
CIRP contributes to multiple organ damage in acute pancreatitis by increasing endothelial permeability., PMID:40065057
Expression of cold-inducible RNA-binding protein in mouse spinal cord injury model., PMID:40036292
Convergent Gene Duplication in Arctic and Antarctic Teleost Fishes., PMID:39932755
Hydrogen sulfide attenuates sepsis-induced cardiac dysfunction in infant rats by inhibiting the expression of cold-inducible RNA-binding protein., PMID:39907066
Assessing donor kidney function: the role of CIRBP in predicting delayed graft function post-transplant., PMID:39896811
Ferroptosis-Related Transcriptional Level Changes and the Role of CIRBP in Glioblastoma Cells Ferroptosis., PMID:39857625
Transcriptomic Insights into Dual Temperature-Salinity Stress Response in "Shuike No. 1", a Pioneering Rainbow Trout Strain Bred in China., PMID:39857280
Extracellular cold-inducible RNA-binding protein in CNS injury: molecular insights and therapeutic approaches., PMID:39838468
An eCIRP inhibitor attenuates fibrosis and ferroptosis in ischemia and reperfusion induced chronic kidney disease., PMID:39794717
Oxygen-dependent alternative mRNA splicing and a cone-specific motor protein revealed by single-cell RNA sequencing in hypoxic retinas., PMID:39638278
DNA repair and anti-cancer mechanisms in the long-lived bowhead whale., PMID:39574710
Cold shock proteins CIRBP and RBM3 may indicate hypothermia death: A case report., PMID:39550904
Mechanism of lactic acidemia-promoted pulmonary endothelial cells death in sepsis: role for CIRP-ZBP1-PANoptosis pathway., PMID:39465383
Milk fat globule-epidermal growth factor-VIII-derived oligopeptide 3 (MOP3) attenuates inflammation and improves survival in hepatic ischemia/reperfusion injury., PMID:39455391
AAV9-mediated CIRP gene transfer protects against cardiac dysfunction and remodelling in a rat model of myocardial infarction., PMID:39400399
Molecular characterization of CIRBP from Takifugu fasciatus and its potential roles in cold-induced liver damage., PMID:39393746
Identification and validation of ferroptosis-related biomarkers in intervertebral disc degeneration., PMID:39351146
Decreased cold-inducible RNA-binding protein (CIRP) binding to GluRl on neuronal membranes mediates memory impairment resulting from prolonged hypobaric hypoxia exposure., PMID:39315498
An anti-eCIRP strategy for necrotizing enterocolitis., PMID:39304832
Construction and validation of a prognostic model for esophageal cancer based on prognostic-related RNA-binding protein., PMID:39287291
Integrating transcriptomics and proteomics to analyze the immune microenvironment of cytomegalovirus associated ulcerative colitis and identify relevant biomarkers., PMID:39192288
Cold shock therapy promotes hair growth in association with upregulation of cold-inducible RNA-binding protein and vascular endothelial growth factor., PMID:39181732
A NOVEL OPSONIC EXTRACELLULAR CIRP INHIBITOR MOP3 ALLEVIATES GUT ISCHEMIA/REPERFUSION INJURY., PMID:39178245
Hypoxia-enhanced YAP1-EIF4A3 interaction drives circ_0007386 circularization by competing with CRIM1 pre-mRNA linear splicing and promotes non-small cell lung cancer progression., PMID:39030638
Retarded astrogliogenesis in response to hypoxia is facilitated by downregulation of CIRBP., PMID:39024953
Cold inducible RNA binding protein-regulated mitochondria associated endoplasmic reticulum membranes-mediated Ca2+ transport play a critical role in hypothermia cerebral resuscitation., PMID:38992825
Unraveling the intricacies of cold-inducible RNA-binding protein: A comprehensive review., PMID:38969204
BMAL2 promotes eCIRP-induced macrophage endotoxin tolerance., PMID:38938563
Radiation-induced eCIRP impairs macrophage bacterial phagocytosis., PMID:38920274
Extracellular CIRP promotes Kupffer cell inflammatory polarization in sepsis., PMID:38881891
Inhibition of CIRBP represses the proliferation and migration of vascular smooth muscle cells via inhibiting Rheb/mTORC1 axis., PMID:38870847
Genomic analysis uncovers that cold-inducible RNA binding protein is associated with estrogen receptor in breast cancer., PMID:38847971
Associations of cold-inducible RNA-binding protein with bacterial load, proinflammatory cytokines and mortality from pneumonia., PMID:38807464
SUGP2 p.(Arg639Gln) variant is involved in the pathogenesis of hemochromatosis via the CIRBP/BMPER signaling pathway., PMID:38800953
Cirbp suppression compromises DHODH-mediated ferroptosis defense and attenuates hypothermic cardioprotection in an aged donor transplantation model., PMID:38690728
Harnessing extracellular cold-inducible RNA binding protein by PS-OMe miR130: A promising shield against hemorrhage-induced lung injury., PMID:38685193
The Novel MFG-E8-derived Oligopeptide, MOP3, Improves Outcomes in a Preclinical Murine Model of Neonatal Sepsis., PMID:38582704
Extracellular CIRP co-stimulated T cells through IL6R/STAT3 in pediatric IgA vasculitis., PMID:38565387
Upregulation of CIRP by its agonist prevents the development of heart failure in myocardial infarction rats., PMID:38539067
CIRP increases Foxp3+ regulatory T cells and inhibits development of Th17 cells by enhancing TLR4-IL-2 signaling in the late phase of sepsis., PMID:38531201
B-1a cells scavenge NETs to attenuate sepsis., PMID:38484156
ThermomiR-377-3p-induced suppression of Cirbp expression is required for effective elimination of cancer cells and cancer stem-like cells by hyperthermia., PMID:38419081
For research use only. Not for human or drug use.
