Catalog No.
YHG66701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu85-Ala177
Predicted molecular weight
13.01 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13887
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
GC-box-binding protein 2, KLF5, Krueppel-like factor 5, Intestinal-enriched krueppel-like factor, IKLF, BTE-binding protein 2, Transcription factor BTEB2, BTEB2, Colon krueppel-like factor, CKLF, Basic transcription element-binding protein 2
Single-cell transcription reveals hepatocyte-to-cholangiocyte reprogramming and biliary gene profile in biliary atresia., PMID:40366121
Role of KLF5 in enhancing ovarian cancer stemness and PARPi resistance: mechanisms and therapeutic targeting., PMID:40307891
Magnesium Lithospermate B Protects Against Ischemic AKI-to-CKD progression via regulating the KLF5/CDK1/Cyclin B1 pathway., PMID:40262199
Krüppel-like factor 5 remodels lipid metabolism in exercised skeletal muscle., PMID:40250760
Gene expression changes in human cerebral arteries following hemoglobin exposure: implications for vascular responses in SAH., PMID:40247928
Identification and Validation of Ferritinophagy-Related Biomarkers in Periodontitis., PMID:40233623
Transcription factor KLF5 regulates MsrB1 to promote colorectal cancer progression by inhibiting ferroptosis through β-catenin., PMID:40210135
Retraction Note to: KLF5 regulated lncRNA RP1 promotes the growth and metastasis of breast cancer via repressing p27kip1 translation., PMID:40199851
Irradiation of 125I seeds blocks glycolysis in pancreatic cancer by inhibiting KLF5 m6A methylation through the suppression of RBM15., PMID:40147709
Cardiac ischaemia/reperfusion in pigs and mice increases cardiomyocyte Krüppel-like factor 5 that aggravates tissue injury and remodelling., PMID:40079359
TGF-β-induced acetylation of KLF5 drives TNFAIP2 transcription and EMT in nasopharyngeal carcinoma: Unveiling a novel regulatory mechanism., PMID:40054652
KLF5 enhances CXCL12 transcription in adipose-derived stem cells to promote endothelial progenitor cells neovascularization and accelerate diabetic wound healing., PMID:40038579
Finerenone Ameliorates High Glucose-Induced Podocytes Epithelial-Mesenchymal Transition Through the Regulation of Krüppel-Like Factor 5 in Diabetic Nephropathy., PMID:40034482
Porphyromonas gingivalis potentiates stem-like properties of oral squamous cell carcinoma by modulating SCD1-dependent lipid synthesis via NOD1/KLF5 axis., PMID:40016182
FBXW7 mediates high glucose-induced epithelial to mesenchymal transition via KLF5 in renal tubular cells of diabetic kidney disease., PMID:40010183
ASH2L Deficiency in Smooth Muscle Drives Pulmonary Vascular Remodeling., PMID:39996311
Mechanoresponsive patterns of KLF2, 4, 5, and 6 expression differ among subclones from a single mammary tumor., PMID:39983249
[Spatial Organization of Chromatin of the KLF5 Gene Promoter Region in Pancreatic Ductal Adenocarcinoma Cells]., PMID:39970117
Single-Nucleus RNA Sequencing and Spatial Transcriptomics for Squamous Cell Carcinoma Arising From Ovarian Mature Teratoma., PMID:39948701
KLF12 inhibits lipopolysaccharide-induced inflammatory responses, oxidative stress, pyroptosis, and endoplasmic reticulum stress in human airway epithelial cells through inhibition of the NF-κB pathway., PMID:39938687
The miR-1305/KLF5 negative regulatory loop affects pancreatic cancer cell proliferation and apoptosis., PMID:39921786
Comparative transcriptomics reveals a mixed basal, club, and hillock epithelial cell identity in castration-resistant prostate cancer., PMID:39913208
Correction: BRD4-specific PROTAC inhibits basal-like breast cancer partially through downregulating KLF5 expression., PMID:39900726
Single-cell transcriptome atlas of male mouse pituitary across postnatal life highlighting its stem cell landscape., PMID:39898054
Positive Feedback Regulation between KLF5 and XPO1 Promotes Cell Cycle Progression of Basal like Breast Cancer., PMID:39888288
A Regulatory Circuits Analysis Tool, "miRCuit," Helps Reveal Breast Cancer Pathways: Toward Systems Medicine in Oncology., PMID:39853230
LncRNA-HHCP5 Regulates KLF5 in ceRNA and m6A Pathways to Inhibit the Progression of Osteoarthritis., PMID:39835513
Integrating bioinformatics and machine learning to identify AhR-related gene signatures for prognosis and tumor microenvironment modulation in melanoma., PMID:39835132
Inhibition of KLF5 promotes ferroptosis via the ZEB1/HMOX1 axis to enhance sensitivity to oxaliplatin in cancer cells., PMID:39827156
KLF5 loss sensitizes cells to ATR inhibition and is synthetic lethal with ARID1A deficiency., PMID:39779698
Integrative Analysis of Chromatin Accessibility and Transcriptional Landscape Identifies Key Genes During Muscle Development in Pigs., PMID:39768207
Fatty acid desaturase 2 (FADS2) affects the pluripotency of hESCs by regulating energy metabolism., PMID:39756764
Pan-cancer drivers of metastasis., PMID:39748426
KLF5 silencing restrains proliferation, invasion, migration and angiogenesis of gallbladder carcinoma cells by transcriptional regulation of PDGFA., PMID:39704786
Suppression of KLF5 targets RREB1 to restrain the proliferation of ovarian cancer cells through ERK/MAPK signaling pathway., PMID:39676889
Multi-omics joint screening of biomarkers related to M2 macrophages in gastric cancer., PMID:39623254
DNMT aberration-incurred GPX4 suppression prompts osteoblast ferroptosis and osteoporosis., PMID:39617773
Ursolic Acid Inhibits Glycolysis of Ovarian Cancer via KLF5/PI3K/AKT Signaling Pathway., PMID:39614414
Targeting PRMT5 through PROTAC for the treatment of triple-negative breast cancer., PMID:39614393
KLF5 Shapes Developing Respiratory Tubules by Inhibiting Actin Asymmetry in Epithelial Cells., PMID:39556252
Investigating the dysregulation of genes associated with glucose and lipid metabolism in gastric cancer and their influence on immunity and prognosis., PMID:39508713
Differential chromatin accessibility and transcriptional dynamics define breast cancer subtypes and their lineages., PMID:39478117
DNMT3A transcriptionally downregulated by KLF5 alleviates LPS-induced inflammatory response and promotes osteogenic differentiation in hPDLSCs., PMID:39476105
Pterosin B improves cognitive dysfunction by promoting microglia M1/M2 polarization through inhibiting Klf5/Parp14 pathway., PMID:39413455
HDAC6 promotes inflammation in lupus nephritis mice by regulating transcription factors MAFF and KLF5 in renal fibrosis., PMID:39412062
Renoprotective effect of liraglutide on diabetic nephropathy by modulation of Krüppel-like transcription factor 5 expression in rats., PMID:39403839
LN-439A, a novel BAP1 inhibitor, suppresses the growth of basal-like breast cancer by degrading KLF5., PMID:39379684
Xenotransplanted human organoids identify transepithelial zinc transport as a key mediator of intestinal adaptation., PMID:39375337
Early growth response 1 exacerbates thoracic aortic aneurysm and dissection of mice by inducing the phenotypic switching of vascular smooth muscle cell through the activation of Krüppel-like factor 5., PMID:39345002
NEDD4L affects KLF5 stability through ubiquitination to control ferroptosis and radiotherapy resistance in oesophageal squamous cell carcinoma., PMID:39317954
For research use only. Not for human or drug use.
