Catalog No.
YHG66101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser27-Thr150
Predicted molecular weight
16.21 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13873
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
BMP type II receptor, BMPR-II, Bone morphogenetic protein receptor type II, Bone morphogenetic protein receptor type-2, BMPR2, PPH1, BMP type-2 receptor, BMPR-2
Exosomal BMPR2 Macromolecule Facilitates Alveolar Epithelial Cell Repair Through Functional Complex Formation with BMPR1B in Acute Lung Injury., PMID:40502982
Case Report: Pulmonary arterial hypertension in children caused by a new mutation in the BMPR2 gene., PMID:40496024
[Mechanism of Quanduzhong Capsules in treating knee osteoarthritis from perspective of spatial heterogeneity]., PMID:40461230
Evolutionary balance between genomic conservation and coral reef adaptation in the yellow boxfish ( Ostracion cubicus)., PMID:40383970
Acute regulation of murine adipose tissue lipolysis and insulin resistance by the TGFβ superfamily protein GDF3., PMID:40360531
BMPR-II, caspase-3, HIF-1α, and VE-cadherin profile in Down syndrome children with and without congenital heart disease and pulmonary hypertension., PMID:40352250
Anti-Müllerian hormone signalling sustains circadian homeostasis in zebrafish., PMID:40348785
Beyond Repetition: The Role of Gray Zone Alleles in the Upregulation of FMR1-Binding miR-323a-3p and the Modification of BMP/SMAD-Pathway Gene Expression in Human Granulosa Cells., PMID:40244008
Altered maturation and activation state of circulating monocytes is associated with their enhanced recruitment in pulmonary arterial hypertension., PMID:40234964
The prevalence of pathogenic variants in the BMPR2 gene in patients with the idiopathic pulmonary arterial hypertension in the Russian population: sequencing data and meta-analysis., PMID:40229839
The sonic hedgehog signaling inhibitor cyclopamine improves pulmonary arterial hypertension via regulating the bone morphogenetic protein receptor 2 pathway., PMID:40216933
Endothelial SMAD4 Deficiency Promotes Pulmonary Hypertension by Impairing Cell Adhesion and Extracellular Matrix Organization., PMID:40211949
Therapeutic potential of allosteric HECT E3 ligase inhibition., PMID:40179885
GDF15 promotes trophoblast invasion and pregnancy success via the BMPR1A/BMPR2/p-SMAD1 pathway: Implications for recurrent miscarriage., PMID:40157640
Autocrine GDF10 Inhibits Hepatic Stellate Cell Activation via BMPR2/ALK3 Receptor to Prevent Liver Fibrosis., PMID:40125634
Consistent Safety and Efficacy of Sotatercept for Pulmonary Arterial Hypertension in BMPR2 Mutation Carriers and Noncarriers: A Planned Analysis of a Phase II, Double-Blind, Placebo-controlled Clinical Trial (PULSAR)., PMID:40035659
miR-6402 targets Bmpr2 and negatively regulates mouse adipogenesis., PMID:40028748
Impact of BMPR2 mutation on the severity of pulmonary arterial hypertension: a systematic review and meta-analysis., PMID:40022182
ActRII or BMPR ligands inhibit skeletal myoblast differentiation, and BMPs promote heterotopic ossification in skeletal muscles in mice., PMID:39994804
Genetic screening in cohort of Egyptian patients with pulmonary arterial hypertension disease., PMID:39932607
Exosomes Derived from Dialysis Patients' Serum Enhance Endothelial-Mesenchymal Transition and Calcification in Endothelial Cells., PMID:39899380
Behavioral, biochemical, and molecular characterization of MPTP/p-intoxicated mice., PMID:39884331
The lncRNA DSCR9 is modulated in pulmonary arterial hypertension endothelial cell models and is associated with alterations in the nitric oxide pathway., PMID:39848555
Loss of Type 2 Bone Morphogenetic Protein Receptor Activates NOD-Like Receptor Family Protein 3/Gasdermin E-Mediated Pyroptosis in Pulmonary Arterial Hypertension., PMID:39846318
1,8-Cineole reduces pulmonary vascular remodelling in pulmonary arterial hypertension by restoring intercellular communication and inhibiting angiogenesis., PMID:39813848
Endothelial tip-cell position, filopodia formation and biomechanics require BMPR2 expression and signaling., PMID:39779836
Exploring Bone Morphogenetic Protein-2 and -4 mRNA Expression and Their Receptor Assessment in a Dynamic In Vitro Model of Vascular Calcification., PMID:39768183
High Shear Stress Reduces ERG Causing Endothelial-Mesenchymal Transition and Pulmonary Arterial Hypertension., PMID:39723537
What can we learn from pathophysiology and therapeutic targetable pathways from all genetic causes and associations in PH?, PMID:39711778
Searching for Old and New Small-Molecule Protein Kinase Inhibitors as Effective Treatments in Pulmonary Hypertension-A Systematic Review., PMID:39684570
Investigating the Role of Primary Cilia and Bone Morphogenetic Protein Signaling in Periodontal Ligament Response to Orthodontic Strain In Vivo and In Vitro: A Pilot Study., PMID:39684361
Hemodynamic and Genetic Associations with the Risk of Idiopathic Pulmonary Arterial Hypertension Development in an Ethnic Cohort of Kazakhs., PMID:39682595
Alk1/Endoglin signaling restricts vein cell size increases in response to hemodynamic cues., PMID:39656297
Adaptation of ACMG/AMP guidelines for clinical classification of BMPR2 variants in Pulmonary Arterial Hypertension resolves variants of unclear pathogenicity in ClinVar., PMID:39649591
SMAD5 as a novel gene for familial pulmonary arterial hypertension., PMID:39631055
LncRNA MYOSLID contributes to PH via targeting BMPR2 signaling in pulmonary artery smooth muscle cell., PMID:39549862
Vitamin D receptor and its antiproliferative effect in human pulmonary arterial hypertension., PMID:39523384
Recapitulating the adenoma-carcinoma sequence by selection of four spontaneous oncogenic mutations in mismatch-repair-deficient human colon organoids., PMID:39487295
Regulation of Bone Morphogenetic Protein Receptor Type II Expression by FMR1/Fragile X Mental Retardation Protein in Human Granulosa Cells in the Context of Poor Ovarian Response., PMID:39408972
StratosPHere 2: study protocol for a response-adaptive randomised placebo-controlled phase II trial to evaluate hydroxychloroquine and phenylbutyrate in pulmonary arterial hypertension caused by mutations in BMPR2., PMID:39407331
Cathepsin L Promotes Pulmonary Hypertension via BMPR2/GSDME-Mediated Pyroptosis., PMID:39403807
Whole-exome sequencing reveals the genetic causes and modifiers of moyamoya syndrome., PMID:39367156
BMP receptor 2 inhibition regulates mitochondrial bioenergetics to induce synergistic cell death with BCL-2 inhibitors in leukemia and NSLC cells., PMID:39315260
MSC-derived exosomes attenuates pulmonary hypertension via inhibiting pulmonary vascular remodeling., PMID:39299482
High relative humidity environment alleviates hypoxia-induced pulmonary arterial hypertension in mice., PMID:39276695
Reversal of pulmonary veno-occlusive disease phenotypes by inhibition of the integrated stress response., PMID:39196173
Levosimendan mediates the BMP/Smad axis through upregulation of circUSP34-targeted miR-1298 to alleviate pulmonary hypertension., PMID:39160536
Growth Differentiation Factor 11 Evokes Lung Injury, Inflammation, and Fibrosis in Mice through the Activin A Receptor Type II-Like Kinase, 53kDa-Smad2/3 Signaling Pathway., PMID:39147236
Emerging role of BMPs/BMPR2 signaling pathway in treatment for pulmonary fibrosis., PMID:39142248
Effects of Modulating BMP9, BMPR2, and AQP1 on BMP Signaling in Human Pulmonary Microvascular Endothelial Cells., PMID:39125626
For research use only. Not for human or drug use.
