Catalog No.
YHG65701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asn500-Asn742
Predicted molecular weight
53.27 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13835
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
B6P, Plakophilin-1, Band 6 protein, PKP1
Discovery of new protein partners of anterior gradient 2 (AGR2) from cell-cell adhesion pathway using genetically-encoded photo-crosslinker DiZPK., PMID:40367911
Multi-omics analysis unveils a four-gene prognostic signature in esophageal squamous carcinoma and the therapeutic potential of PKP1., PMID:40281492
Differential gene expression analysis and machine learning identified structural, TFs, cytokine and glycoproteins, including SOX2, TOP2A, SPP1, COL1A1, and TIMP1 as potential drivers of lung cancer., PMID:39888730
Chemical structures and immunomodulatory activities of polysaccharides from Polygonatum kingianum., PMID:39245127
Plakophilin 1 in carcinogenesis., PMID:38888207
Unveiling the Binding between the Armadillo-Repeat Domain of Plakophilin 1 and the Intrinsically Disordered Transcriptional Repressor RYBP., PMID:38785968
The role of PKP1 in tumor progression in melanoma: Analysis of a cell adhesion-related model., PMID:37966033
LY6/PLAUR domain containing 3 (LYPD3) maintains melanoma cell stemness and mediates an immunosuppressive microenvironment., PMID:37924160
The pyruvate dehydrogenase complex regulates mitophagic trafficking and protein phosphorylation., PMID:37442609
Elucidation of the inhibitory potential of flavonoids against PKP1 protein in non-small cell lung cancer., PMID:37114302
Integrated bioinformatics analyses identifying key transcriptomes correlated with prognosis and immune infiltrations in lung squamous cell carcinoma., PMID:36879671
Plakophilin 1 deficiency in prostatic tumours is correlated with immune cell recruitment and controls the up-regulation of cytokine expression post-transcriptionally., PMID:36380691
The armadillo-repeat domain of Plakophilin 1 binds to human enzyme PADI4., PMID:36372391
Complementary evolution of coding and noncoding sequence underlies mammalian hairlessness., PMID:36342464
Network exploration of gene signatures underlying low birth weight induced metabolic alterations., PMID:36316897
Plakophilin 2 regulates intestinal barrier function by modulating protein kinase C activity in vitro., PMID:36280901
Integrated analysis of bulk and single-cell RNA sequencing reveals the interaction of PKP1 and tumor-infiltrating B cells and their therapeutic potential for nasopharyngeal carcinoma., PMID:36186467
Bidirectional regulation of desmosome hyperadhesion by keratin isotypes and desmosomal components., PMID:35380280
PKP1 and MYC create a feedforward loop linking transcription and translation in squamous cell lung cancer., PMID:35182388
Identification of Potential Core Genes Between Primary and Metastatic Malignant Melanoma and Analysis of Their Immune Correlation., PMID:35046701
Novel Point Mutation of EBSS Gene Coexisted with 1p36 Deletion., PMID:34616129
Desmosomal proteins of DSC2 and PKP1 promote cancer cells survival and metastasis by increasing cluster formation in circulatory system., PMID:34586853
The Prognostic Significance of Plakophilin-1 Expression in Esophageal Cancer., PMID:34230135
The armadillo-repeat domain of plakophilin 1 binds the C-terminal sterile alpha motif (SAM) of p73., PMID:33872756
Intrinsically disordered protein NUPR1 binds to the armadillo-repeat domain of Plakophilin 1., PMID:33385445
Identification of PKP 2/3 as potential biomarkers of ovarian cancer based on bioinformatics and experiments., PMID:33088217
Desmosomal Hyperadhesion Is Accompanied with Enhanced Binding Strength of Desmoglein 3 Molecules., PMID:33031738
Screening and identification of potential prognostic biomarkers in metastatic skin cutaneous melanoma by bioinformatics analysis., PMID:32869947
Deregulation of desmosomal proteins and extracellular matrix proteases in odontogenic keratocyst., PMID:32772410
The isolated armadillo-repeat domain of Plakophilin 1 is a monomer in solution with a low conformational stability., PMID:32650131
[Histopathological and genetical diagnosis of one case of neonatal ectodermal dysplasia/skin fragility syndrome]., PMID:32594712
Mutations in genes encoding desmosomal proteins: spectrum of cutaneous and extracutaneous abnormalities., PMID:32593191
LncRNA APPAT regulated miR-328a/Pkp1 signal pathway to participate in breast cancer., PMID:32495884
Analysis of gene expression profiles of lung cancer subtypes with machine learning algorithms., PMID:32360590
Novel homozygous deletion of the plakophilin-1 gene in a Chinese patient with ectodermal dysplasia-skin fragility syndrome., PMID:32346906
Ectodermal dysplasia-skin fragility syndrome: Two new cases and review of this desmosomal genodermatosis., PMID:32248567
Identification of Specific Tumor Markers in Vulvar Carcinoma Through Extensive Human Papillomavirus DNA Characterization Using Next Generation Sequencing Method., PMID:31860576
Evidence for the Desmosomal Cadherin Desmoglein-3 in Regulating YAP and Phospho-YAP in Keratinocyte Responses to Mechanical Forces., PMID:31835537
Plakophilin 1 enhances MYC translation, promoting squamous cell lung cancer., PMID:31822797
The value of desmosomal plaque-related markers to distinguish squamous cell carcinoma and adenocarcinoma of the lung., PMID:31809668
Phosphorylation of mitochondrial matrix proteins regulates their selective mitophagic degradation., PMID:31548421
Gene expression in stress urinary incontinence: a systematic review., PMID:31312847
Genome Resequencing Reveals Congenital Causes of Embryo and Nestling Death in Crested Ibis (Nipponia nippon)., PMID:31298688
Plakophilin 1 but not plakophilin 3 regulates desmoglein clustering., PMID:30949721
Plakophilin 1 is methylated and has a tumor suppressive activity in human lung cancer., PMID:30946843
Coexpression network analysis identified that plakophilin 1 is associated with the metastasis in human melanoma., PMID:30841437
Searching for serum protein markers of equine squamous gastric disease using gel electrophoresis and mass spectrometry., PMID:30636330
Altered levels of focal adhesion and extracellular matrix-receptor interacting proteins were identified in Hailey-Hailey disease by quantitative iTRAQ proteome analysis., PMID:30506709
14-3-3 proteins regulate desmosomal adhesion via plakophilins., PMID:29678907
RIPK4 activity in keratinocytes is controlled by the SCFβ-TrCP ubiquitin ligase to maintain cortical actin organization., PMID:29435596
For research use only. Not for human or drug use.
