Catalog No.
YHG65301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser637-Ile863
Predicted molecular weight
28.46 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13822
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
LysoPLD, Extracellular lysophospholipase D, ENPP2, Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, E-NPP 2, PDNP2, Autotaxin, ATX
Biomarkers of Calcification, Endothelial Injury, and Platelet-Endothelial Interaction in Patients with Aortic Valve Stenosis., PMID:40430015
Do Single-Nucleotide Polymorphisms Affect Pain Intensity and Sufentanil Analgesia After Pediatric Scoliosis Correction Surgery?, PMID:40331998
Elevated serum autotaxin levels and multiple system atrophy-like presentation in a patient with PLA2G6-associated neurodegeneration., PMID:40263418
Rate of Decrease in Serum Autotaxin Can Predict Relapse of Type 1 Autoimmune Pancreatitis After Initial Steroid Therapy., PMID:40237760
Dysregulated ATX-LPA and YAP/TAZ signaling in dystrophic Sgcd-/- mice with early fibrosis and inflammation., PMID:40050938
Association of escitalopram-induced shifts in gut microbiota and sphingolipid metabolism with depression-like behavior in wistar-kyoto rats., PMID:39962083
Structure-Based Discovery of MolPort-137: A Novel Autotaxin Inhibitor That Improves Paclitaxel Efficacy., PMID:39859312
Myeloid-specific deletion of autotaxin inhibits rheumatoid arthritis and osteoclastogenesis., PMID:39744622
ENPP2 promotes progression and lipid accumulation via AMPK/SREBP1/FAS pathway in chronic lymphocytic leukemia., PMID:39731014
Tadalafil Enhances the Therapeutic Efficacy of Mesenchymal Stem Cells-Derived Exosomes in Pulmonary Hypertension by Upregulating miR-29a-3p., PMID:39720214
Transcriptional regulation of basophil-specific protease genes by C/EBPα, GATA2, TGF-β signaling, and epigenetic mechanisms., PMID:39660487
Pancreatic CAF-Derived Autotaxin Drives Autocrine CTGF Expression to Modulate Protumorigenic Signaling., PMID:39570650
Serum Autotaxin Levels Predict Liver-Related Events in Patients With Primary Biliary Cholangitis: A Long-Term Multicenter Observational Study., PMID:39466702
Knockdown of microglial iron import gene, Slc11a2, worsens cognitive function and alters microglial transcriptional landscape in a sex-specific manner in the APP/PS1 model of Alzheimer's disease., PMID:39334471
Aquilaria crassna Extract Exerts Neuroprotective Effect against Benzo[a]pyrene-Induced Toxicity in Human SH-SY5Y Cells: An RNA-Seq-Based Transcriptome Analysis., PMID:39203863
Lysophosphatidic Acid Receptors LPAR5 and LPAR2 Inversely Control Hydroxychloroquine-Evoked Itch and Scratching in Mice., PMID:39125747
Increased Thyroid Hormone Action Alleviates Hippocampal Damage by Downregulating Neuronal Type I Interferon Signaling/Necroptosis in Diabetes-Associated Cognitive Dysfunction., PMID:39104259
Autotaxin-Lysophosphatidate Axis: Promoter of Cancer Development and Possible Therapeutic Implications., PMID:39062979
Lysophosphatidic acid receptor 1 inhibition: a potential treatment target for pulmonary fibrosis., PMID:39009409
Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts., PMID:39002541
Lysophosphatidic acid metabolism and signaling in heart disease., PMID:38968609
Tumour-specific activation of a tumour-blood transport improves the diagnostic accuracy of blood tumour markers in mice., PMID:38889481
Characterization of Lysophospholipase D Activity in Mammalian Cell Membranes., PMID:38534364
ENPP2/Autotaxin: The potential drug target for alcoholic liver disease identified through Mendelian randomization analysis., PMID:38517150
Autotaxin and Lysophosphatidate Signaling: Prime Targets for Mitigating Therapy Resistance in Breast Cancer., PMID:38274724
Cross-Platform Identification and Validation of Uveal Melanoma Vitreous Protein Biomarkers., PMID:37955612
Creation of a Rat Takotsubo Syndrome Model and Utilization of Machine Learning Algorithms for Screening Diagnostic Biomarkers., PMID:37901384
Autotaxin in encephalitogenic CD4 T cells as a therapeutic target for multiple sclerosis., PMID:37850588
Autotaxin-lysophosphatidic acid receptor 5 axis evokes endothelial dysfunction via reactive oxygen species signaling., PMID:37837357
The autotaxin-LPA axis promotes membrane trafficking and secretion in yolk sac visceral endoderm cells., PMID:37795611
[Keloid nomogram prediction model based on weighted gene co-expression network analysis and machine learning]., PMID:37666763
The Evaluation of Adropin and Autotaxin as Potential Markers of Endothelial Dysfunction in Preeclampsia., PMID:37587899
Autotaxin inhibitor IOA-289 reduces gastrointestinal cancer progression in preclinical models., PMID:37550785
Establishment and clinical application evaluations of a deep mining strategy of plasma proteomics based on nanomaterial protein coronas., PMID:37524462
ENPP2 inhibitor improves proliferation in AOM/DSS-induced colorectal cancer mice via remodeling the gut barrier function and gut microbiota composition., PMID:37524154
Age-related decline in bone mineral transport and bone matrix proteins in osteoblasts from stromal stem cells., PMID:37519232
E2F7 drives autotaxin/Enpp2 transcription via chromosome looping: Repression by p53 in murine but not in human carcinomas., PMID:37358838
Autotaxin promotes the degradation of the mucus layer by inhibiting autophagy in mouse colitis., PMID:37356325
Stage Analysis of Breast Cancer Metabolomics: A System Biology Approach., PMID:37247276
Combined inhibition of EZH2 and the autotaxin-LPA-LPA2 axis exerts synergistic antitumor effects on colon cancer cells., PMID:37230222
Hypoxia Increases ATX Expression by Histone Crotonylation in a HIF-2α-Dependent Manner., PMID:37108194
LPA1 receptors in the lateral habenula regulate negative affective states associated with alcohol withdrawal., PMID:37059867
Role of enterocyte Enpp2 and autotaxin in regulating lipopolysaccharide levels, systemic inflammation, and atherosclerosis., PMID:37059333
ENPP2 alleviates hypoxia/reoxygenation injury and ferroptosis by regulating oxidative stress and mitochondrial function in human cardiac microvascular endothelial cells., PMID:37052764
RNA-seq reveals that anti-obesity irisin and triiodothyronine (T3) hormones differentially affect the purinergic signaling transcriptomics in differentiated human adipocytes., PMID:36642213
Autotaxin facilitates selective LPA receptor signaling., PMID:36640760
Linking medicinal cannabis to autotaxin-lysophosphatidic acid signaling., PMID:36623871
Autotaxin and Lysophosphatidic Acid Signalling: the Pleiotropic Regulatory Network in Cancer., PMID:38583176
The mechanism of Renshen-Fuzi herb pair for treating heart failure-Integrating a cardiovascular pharmacological assessment with serum metabolomics., PMID:36545315
Cerebrospinal fluid levels of sortilin-1, lipocalin-2, autotaxin, decorin and interleukin-33 in patients with idiopathic intracranial hypertension., PMID:36535285
For research use only. Not for human or drug use.
