Catalog No.
YHG63501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala1657-Leu1873
Predicted molecular weight
25.42 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13698
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle, Voltage-dependent L-type calcium channel subunit alpha-1S, CACN1, CACH1, CACNL1A3, CACNA1S, Voltage-gated calcium channel subunit alpha Cav1.1
Troponin T3 ameliorates sepsis-induced diaphragm dysfunction in rats through modulation of Cacna1s., PMID:40460485
ITIH4 attenuates acute lung injury by Fe-containing particulate matter in mice via Hippo pathway in type II alveolar epithelial cells., PMID:40437524
Comprehensive transcriptomic analysis integrating bulk and single-cell RNA-seq with machine learning to identify and validate mitochondrial unfolded protein response biomarkers in patients with ischemic stroke., PMID:40313716
Identifying therapeutic target genes for diabetic retinopathy using systematic druggable genome-wide Mendelian randomization., PMID:40301928
Genetic editing of primary human dorsal root ganglion neurons using CRISPR-Cas9., PMID:40169710
Spatial Transcriptomics and Proteomics Profiling After Ischemic Stroke Reperfusion: Insights Into Vascular Alterations., PMID:40052263
CACNA1S-associated triadopathy presenting with myalgia, muscle weakness, and asymptomatic hyperCKemia., PMID:40018084
[Hypokalemia: Not Just Tubulopathies]., PMID:39931966
Updating probability of pathogenicity for RYR1 and CACNA1S exon variants in individuals without malignant hyperthermia after exposure to triggering anesthetics., PMID:39745345
Exploring variances in meat quality between Qingyuan partridge chicken and Cobb broiler: Insights from combined multi-omics analysis., PMID:39721276
Muscle Contractility in Hypokalemic Periodic Paralysis., PMID:39719667
A Homozygous MYH1 Variant Underlies Autosomal Recessive Isolated Recurrent Rhabdomyolysis., PMID:39687948
Mechanistic insights into retinoic-acid treatment for autism in the improvement of social behavior: Evidence from a multi omics study in rats., PMID:39643238
A clinical case of CACNA1S-related muscle weakness in a Holstein calf with congenital astasia diagnosed by a genotyping test of stored blood., PMID:39551494
A new case with coexistence of mosaic 48,XYYY/47,XYY, and CACNA1E variant in autism spectrum disorder., PMID:39526683
Novel ryanodine receptor 1 (RYR1) missense gene variants in two pet dogs with fatal malignant hyperthermia identified by next-generation sequencing., PMID:39516111
Familial hypokalemic periodic paralysis: a case induced by concurrent hyperthyroidism., PMID:39333966
Gene co-expression network and differential expression analyses reveal key genes for weaning weight in Simmental-Holstein crossbred cattle., PMID:39301708
Association Study of CACNA1D, KCNJ11, KCNQ1, and CACNA1E Single-Nucleotide Polymorphisms with Type 2 Diabetes Mellitus., PMID:39273144
MODY Only Monogenic? A Narrative Review of the Novel Rare and Low-Penetrant Variants., PMID:39201476
CaV1.1 voltage-sensing domain III exclusively controls skeletal muscle excitation-contraction coupling., PMID:39198449
Periodic paralysis., PMID:39174253
What is in the Myopathy Literature?, PMID:39163158
Investigation of single nucleotide polymorphisms in differentially expressed genes and proteins reveals the genetic basis of skeletal muscle growth differences between Tibetan and Large White pigs., PMID:38938033
Structural insights into the allosteric effects of the antiepileptic drug topiramate on the CaV2.3 channel., PMID:38901222
Human Genetics of Ventricular Septal Defect., PMID:38884729
Bioinformatics gene analysis for potential biomarkers and therapeutic targets of Parkinson's disease based on neutrophil extracellular traps., PMID:38882525
Quality of life in hypokalemic periodic paralysis - a survey., PMID:38870649
Pronociceptive role of spinal Cav2.3 (R-type) calcium channels in a mouse model of postoperative pain., PMID:38812100
Early-Onset Autosomal Dominant Myopathy with Vacuolated Fibers and Tubular Aggregates but No Periodic Paralysis, in a Patient with the c.1583G>A (p.R528H) mutation in the CACNA1S Gene., PMID:38788083
G protein β subunits regulate Cav3.3 T-type channel activity and current kinetics via interaction with the Cav3.3 C-terminus., PMID:38763272
Incidence of statin-associated muscle symptoms in patients taking statins with RYR1 or CACNA1S variants., PMID:38722226
Baicalin restore intestinal damage after early-life antibiotic therapy: the role of the MAPK signaling pathway., PMID:38663526
Genetic analysis of 37 cases with primary periodic paralysis in Chinese patients., PMID:38609989
Case report: Dihydropyridine receptor (CACNA1S) congenital myopathy, a novel phenotype with early onset periodic paralysis., PMID:38426167
Detection of the T1640C RYR1 mutation indicating malignant hyperthermia in dogs., PMID:38163044
Identification of novel candidate genes associated with non-syndromic tooth agenesis in Mongolian families., PMID:38157055
Epidemiological and clinical features of malignant hyperthermia: A scoping review., PMID:38148504
Biallellic variants in CACNA1S cause fetal akinesia sequence, progressive hydrops and stillbirth., PMID:38111203
Epilepsy-linked kinase CDKL5 phosphorylates voltage-gated calcium channel Cav2.3, altering inactivation kinetics and neuronal excitability., PMID:38081835
Effects of Remimazolam on Intracellular Calcium Dynamics in Myotubes Derived from Patients with Malignant Hyperthermia and Functional Analysis of Type 1 Ryanodine Receptor Gene Variants., PMID:38002952
Two zebrafish cacna1s loss-of-function variants provide models of mild and severe CACNA1S-related myopathy., PMID:37930228
Functional enrichment analysis of mutated genes in children with hyperthyroidism., PMID:37876543
Evaluation of Malignant Hyperthermia Features in Patients with Pathogenic or Likely Pathogenic RYR1 Variants Disclosed through a Population Genomic Screening Program., PMID:37787745
A novel CACNA1S gene variant in a child with hypokalemic periodic paralysis: a case report and literature review., PMID:37784084
LncRNA-associated competing endogenous RNA network analysis uncovered key lncRNAs involved in temozolomide resistance and tumor recurrence of glioblastoma., PMID:37720935
CACNA1S Variant Associated With a Myalgic Myopathy Phenotype., PMID:37679049
Methylation Profile of Small Breast Cancer Tumors Evaluated by Modified MS-HRM., PMID:37628841
Ethanol Causes Cell Death and Neuronal Differentiation Defect During Initial Neurogenesis of the Neural Retina by Disrupting Calcium Signaling in Human Retinal Organoids., PMID:37603136
Role of Cav2.3 (R-type) Calcium Channel in Pain and Analgesia: A Scoping Review., PMID:37581322
For research use only. Not for human or drug use.
