Catalog No.
YHG61201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Glu250
Predicted molecular weight
31.26 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13616
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Cullin-1, CUL-1, CUL1
A gallium fluoride-18 complex containing a pentadentate macrocyclic ligand with a dimethylaminostilbene functional group designed for diagnostic imaging of Alzheimer's disease., PMID:40358251
FBXO22 deficiency defines a pleiotropic syndrome of growth restriction and multi-system anomalies associated with a unique epigenetic signature., PMID:40215970
CUL1-neddylation contributes to K29-linked ubiquitination on p27 for autophagic degradation in sorafenib-resistant liver cancer., PMID:40111576
5'tiRNA-35-GlyTCC-3 and 5'tiRNA-33-CysGCA-11 target BMP6, CUL1 and SPR of non-syndromic cleft palate., PMID:40012056
Molecular mechanisms of CAND2 in regulating SCF ubiquitin ligases., PMID:40011427
SCFRMF-dependent degradation of the nuclear lamina releases the somatic chromatin mobility restriction for meiotic recombination., PMID:39982989
Omics data integration analysis identified new biological insights into chronic antibody-mediated rejection (CAMR)., PMID:39979925
Orientia tsutsugamushi alters the intranuclear balance of cullin-1 and c-MYC to inhibit apoptosis., PMID:39976440
Structural Insight Into the SKP1-CUL1-FBXO3-RBX1 Complex., PMID:39921442
HSC70 coordinates COP9 signalosome and SCF ubiquitin ligase activity to enable a prompt stress response., PMID:39915298
COP9 SIGNALOSOME SUBUNIT 5A facilitates POLYAMINE OXIDASE 5 degradation to regulate strawberry plant growth and fruit ripening., PMID:39899466
C-terminal amides mark proteins for degradation via SCF-FBXO31., PMID:39880951
CUL4-Based Ubiquitin Ligases in Chromatin Regulation: An Evolutionary Perspective., PMID:39851492
F-box protein Fbx23 acts as a transcriptional coactivator to recognize and activate transcription factor Ace1., PMID:39836692
SKP1-CUL1-F-box: Key molecular targets affecting disease progression., PMID:39812503
Identification and analysis of drought-responsive F-box genes in upland rice and involvement of OsFBX148 in ABA response and ROS accumulation., PMID:39581968
Mitoxantrone attenuates lipopolysaccharide-induced acute lung injury via inhibition of NEDD8 activating enzyme., PMID:39541844
Establishment of the auxin inducible degron system for Babesia duncani: a conditional knockdown tool to study precise protein regulation in Babesia spp., PMID:39478572
A Bacterial Platform for Studying Ubiquitination Cascades Anchored by SCF-Type E3 Ubiquitin Ligases., PMID:39456142
Distinct Regions within SAP25 Recruit O-Linked Glycosylation, DNA Demethylation, and Ubiquitin Ligase and Hydrolase Activities to the Sin3/HDAC Complex., PMID:39435885
Structure of the CUL1-RBX1-SKP1-FBXO4 SCF ubiquitin ligase complex., PMID:39406020
Neddylation and Its Target Cullin 3 Are Essential for Adipocyte Differentiation., PMID:39404417
Regular exercise suppresses steatosis-associated liver cancer development by degrading E2F1 and c-Myc via circadian gene upregulation., PMID:39357875
CUL1 exacerbates glucocorticoid-induced osteoporosis by enhancing ASAP1 ubiquitination., PMID:39287759
Discovery of Novel [1,2,4]Triazolo[1,5-a]pyrimidine Derivatives as Novel Potent S-Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer., PMID:39285177
Scaled and efficient derivation of loss-of-function alleles in risk genes for neurodevelopmental and psychiatric disorders in human iPSCs., PMID:39270650
FBXO38 is dispensable for PD-1 regulation., PMID:39266770
Sugar-mediated non-canonical ubiquitination impairs Nrf1/NFE2L1 activation., PMID:39116872
Functional characterization of Cullin-1-RING ubiquitin ligase (CRL1) complex in Leishmania infantum., PMID:39018347
Proteomic analysis reveals a PLK1-dependent G2/M degradation program and a role for AKAP2 in coordinating the mitotic cytoskeleton., PMID:39018246
Fbxo28 is essential for spindle migration and morphology during mouse oocyte meiosis I., PMID:38960234
Molecular insights and clinical implications for the tumor suppressor role of SCFFBXW7 E3 ubiquitin ligase., PMID:38909632
Comprehensive analysis of the Cullin family of genes reveals that CUL7 and CUL9 are the significant prognostic biomarkers in colorectal cancer., PMID:38883340
The F-box protein OsFBX156 positively regulates rice defence against the blast fungus Magnaporthe oryzae by mediating ubiquitination-dependent degradation of OsHSP71.1., PMID:38808386
FBXO42 activity is required to prevent mitotic arrest, spindle assembly checkpoint activation and lethality in glioblastoma and other cancers., PMID:38774470
SCFFBXW5-mediated degradation of AQP3 suppresses autophagic cell death through the PDPK1-AKT-MTOR axis in hepatocellular carcinoma cells., PMID:38726865
Geranylgeranylated-SCFFBXO10 Regulates Selective Outer Mitochondrial Membrane Proteostasis and Function., PMID:38659932
Dysregulated NUB1 and Neddylation Enhances Rheumatoid Arthritis Fibroblast-Like Synoviocyte Inflammatory Responses., PMID:38566346
Scaled and Efficient Derivation of Loss of Function Alleles in Risk Genes for Neurodevelopmental and Psychiatric Disorders in Human iPSC., PMID:38562852
Regulation of the water channel aquaporin-2 by cullin E3 ubiquitin ligases., PMID:38545647
Distinct regions within SAP25 recruit O-linked glycosylation, DNA demethylation, and ubiquitin ligase and hydrolase activities to the Sin3/HDAC complex., PMID:38496433
Inhibition of glycogen synthase kinase-3 enhances NRF2 protein stability, nuclear localisation and target gene transcription in pancreatic beta cells., PMID:38479223
COP9 signalosome complex is a prognostic biomarker and corresponds with immune infiltration in hepatocellular carcinoma., PMID:38466642
eEF1A2 promotes PTEN-GSK3β-SCF complex-dependent degradation of Aurora kinase A and is inactivated in breast cancer., PMID:38442201
FBXL4: safeguarding against mitochondrial depletion through suppression of mitophagy., PMID:38423516
Identification and Validation of Lipid Metabolism Gene FASN-Associated miRNA in Wilms Tumor., PMID:38416272
Skp1 proteins are structural components of the synaptonemal complex in C. elegans., PMID:38354250
SERTAD1 initiates NLRP3-mediated inflammasome activation through restricting NLRP3 polyubiquitination., PMID:38341852
Exploration of functional relations among differentially co-expressed genes identifies regulators in glioblastoma., PMID:38335855
Exploiting the Cullin E3 Ligase Adaptor Protein SKP1 for Targeted Protein Degradation., PMID:38305738
For research use only. Not for human or drug use.
