Catalog No.
YHG59001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu232-Ala477
Predicted molecular weight
30.85 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13568
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
IRF5, Interferon regulatory factor 5, IRF-5
The macrophage-intrinsic MDA5-IRF5 axis drives HIV-1 intron-containing RNA-induced inflammatory responses., PMID:40493408
Novel IgG and IgA autoantibodies validated in two independent cohorts are associated with disease activity and determine organ manifestations in systemic lupus erythematosus: implications for anti-LIN28A, anti-HMGN5, anti-IRF5, and anti-TGIF1., PMID:40348637
IRF5 Mediates Artery Inflammation in Salt-Sensitive Hypertension by Regulating STAT1 and STAT2 Phosphorylation to Increase ESM1 Transcription: Insights from Bioinformatics and Mechanistic Analysis., PMID:40332339
Disruption of the novel nested gene Aff3ir mediates disturbed flow-induced atherosclerosis in mice., PMID:40315012
Natural polyphenol mangiferin delays neuronal cell senescence by inhibiting neuroinflammation mediated by microglial activation., PMID:40271493
IL-10 targets IRF transcription factors to suppress IFN and inflammatory response genes by epigenetic mechanisms., PMID:40263613
Oxaliplatin accelerates immunogenic cell death by activating the cGAS/STING/TBK1/IRF5 pathway in gastric cancer., PMID:40260556
Interferon regulatory factor 5: a potential target for therapeutic intervention in inflammatory diseases., PMID:40213550
Elevation of Plasma IL-15 and RANTES as Potential Biomarkers of Healing in Chronic Venous Ulcerations: A Pilot Study., PMID:40149931
Immunomodulatory Properties of Sweet Whey-Derived Peptides in THP-1 Macrophages., PMID:40142037
Microglia regulate myelin clearance and cholesterol metabolism after demyelination via interferon regulatory factor 5., PMID:40137979
Dysregulation of T Follicular Helper and Regulatory Cells in IRF5-SLE Homozygous Risk Carriers and Systemic Lupus Erythematosus Patients., PMID:40136703
The role of osteopontin in modulating macrophage phagocytosis of calcium oxalate crystals., PMID:40131428
Intermittent hypoxia-reoxygenation-induced miRNAs inhibit expression of IRF and interferon genes but activate NF-κB and expression of pulmonary fibrosis markers in human small airway epithelial cells., PMID:40120975
Transcriptomic and biometric parameters analysis in rainbow trout (Oncorhynchus mykiss) challenged with viral hemorrhagic septicemia virus (VHSV)., PMID:40021981
Placental malaria infection is associated with downregulation of STAT-6 and ANG-1 in decidual macrophages., PMID:40007543
Multi-Omics Analysis of Aberrances and Functional Implications of IRF5 in Digestive Tract Tumours., PMID:39993973
Exploring the association between Mycobacterium avium subspecies paratuberculosis infection and rheumatoid arthritis: an immunological perspective., PMID:39985098
Cytoplasmic Shift of Interferon Regulatory Factors Co-Evolved With Jawed Vertebrate Innate Immunity., PMID:39977406
PFKFB3 decreases α-ketoglutarate production while partial PFKFB3 knockdown in macrophages ameliorates arthritis in tumor necrosis factor-transgenic mice., PMID:39870011
The TLR7/9 adaptors TASL and TASL2 mediate IRF5-dependent antiviral responses and autoimmunity in mouse., PMID:39856058
An essential role for TASL in mouse autoimmune pathogenesis and Toll-like receptor signaling., PMID:39856038
Interferon regulatory factor 5 attenuates kidney fibrosis through transcriptional suppression of Tgfbr1., PMID:39827667
Uncovering selection pressures on the IRF gene family in bats' immune system., PMID:39776231
The structures of the peptide transporters SLC15A3 and SLC15A4 reveal the recognition mechanisms for substrate and TASL., PMID:39719710
Dust mite antigens endow dendritic cells with the capacity to induce a Th2 response by regulating their methylation profiles., PMID:39695662
CCDC134 controls TLR biogenesis through the ER chaperone Gp96., PMID:39656203
Targeting HLA-E in Lung Cancer: The Therapeutic Potential of IRF5-Engineered M1-Macrophage-Derived Exosomes., PMID:39623605
Interferon Regulatory Factors (IRF1, IRF4, IRF5, IRF7 and IRF9) in Sichuan taimen (Hucho bleekeri): Identification and Functional Characterization., PMID:39596618
Panobinostat Attenuates Experimental Autoimmune Encephalomyelitis in Mice via Suppressing Oxidative Stress-Related Neuroinflammation and Mitochondrial Dysfunction., PMID:39596104
IRF5 Controls Plasma Cell Generation and Antibody Production via Distinct Mechanisms Depending on the Antigenic Trigger., PMID:39572974
Inhibitory interferon regulatory factor 5 binding peptide suppresses abdominal aortic aneurysm expansion in vivo., PMID:39490644
Co-delivery of Interferon Regulatory Factor 5 (IRF5) siRNA and dasatinib by a disulfide bond bearing polymeric carrier for enhanced anti-inflammatory effects., PMID:39486736
TBK1 is involved in M-CSF-induced macrophage polarization through mediating the IRF5/IRF4 axis., PMID:39434428
bcIRF5 activates bcTBK1 phosphorylation to enhance PANoptosis during GCRV infection., PMID:39419131
Ultrasound-Responsive Nanocarriers Delivering siRNA and Fe3O4 Nanoparticles Reprogram Macrophages and Inhibit M2 Polarization for Enhanced NSCLC Immunotherapy., PMID:39378273
Poria cocos Extract Alleviates tPA-Induced Hemorrhagic Transformation after Ischemic Stroke through Regulation of Microglia M1/M2 Phenotypes Polarization., PMID:39321038
IRF5 Variants Are Risk Factors for Systemic Lupus Erythematosus in Two Mexican Populations., PMID:39271190
IRF5 mediates adaptive immunity via altered glutamine metabolism, mTORC1 signaling and post-transcriptional regulation following T cell receptor activation., PMID:39253451
Transcriptomic response of lumpfish (Cyclopterus lumpus) head kidney to viral mimic, with a focus on the interferon regulatory factor family., PMID:39211041
The primate-specific presence of interferon regulatory factor-5 pseudogene 1., PMID:39169736
A2 reactive astrocyte-derived exosomes alleviate cerebral ischemia-reperfusion injury by delivering miR-628., PMID:39159174
Genetics of Macrophage Activation Syndrome in Systemic Juvenile Idiopathic Arthritis., PMID:39117811
Evidence of innate training in bovine γδ T cells following subcutaneous BCG administration., PMID:39100669
Pathoimmunological analyses of fatal E11 infection in premature infants., PMID:39045132
Irisin alleviates CFA-induced inflammatory pain by modulating macrophage polarization and spinal glial cell activation., PMID:39042964
IRF5 suppresses metastasis through the regulation of tumor-derived extracellular vesicles and pre-metastatic niche formation., PMID:38969706
Genetic polymorphisms in genes involved in the type I interferon system (STAT4 and IRF5): association with Asian SLE patients., PMID:38963465
Daphnetin Ameliorates Neuropathic Pain via Regulation of Microglial Responses and Glycerophospholipid Metabolism in the Spinal Cord., PMID:38931456
IN VIVO STUDY OF POTENTIAL MECHANISMS OF MACROPHAGE REPOLARIZATION ON THE BACKGROUND OF TUMOR GROWTH., PMID:38852055
For research use only. Not for human or drug use.
