Catalog No.
YHG58101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Asn671
Predicted molecular weight
78.24 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13546
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Receptor-interacting protein 1, RIP1, RIPK1, RIP, Cell death protein RIP, RIP-1, Receptor-interacting serine/threonine-protein kinase 1
Hepatocyte necroptosis is associated with liver damage in dairy cows with ketosis., PMID:40513868
Polymorphisms in Necroptosis Pathway Genes: Novel Prognostic Markers for Multiple Myeloma Treatment Outcomes., PMID:40508046
Distinct Types of Regulated Cell Death in Melanoma., PMID:40497999
From RIPK1 to Necroptosis: Pathogenic Mechanisms in Neurodegenerative Diseases., PMID:40493155
Receptor interacting protein kinase 1 activation and triggering mesangial cells necroptosis in MRL/lpr mice model of lupus nephritis., PMID:40492666
PARP12-mediated mono-ADP-ribosylation as a checkpoint for necroptosis and apoptosis., PMID:40489618
Targeting TBK1 potentiates oncolytic virotherapy via amplifying ICAM1-mediated NK cell immunity in chemo-resistant colorectal cancer., PMID:40484646
Anti-inflammatory mechanism of the MLKL inhibitor necrosulfonamide in LPS- or poly(I:C)-induced neuroinflammation and necroptosis., PMID:40473224
Gambogic acid targets HSP90 to alleviate DSS-induced colitis via inhibiting the necroptosis of intestinal epithelial cells., PMID:40458801
FDA-approved phensuximide inhibits RIPK1-dependent immunogenic cell death., PMID:40456737
Andrographolide prevents necroptosis by suppressing the generation of reactive oxygen species., PMID:40437958
Evolutionary and functional analyses reveal a role for the RHIM in tuning RIPK3 activity across vertebrates., PMID:40434815
Hydrogen Sulfide (H2S) Mitigates Sepsis-Induced Adrenal Dysfunction via Inhibition of TNFα-Mediated Necroptosis., PMID:40430756
Identification of the Cytotoxic Transglutaminase from Mycobacterium spp. That Is Involved in RIPK1 Activation., PMID:40430423
A viral necrosome mediates direct RIPK3 activation to promote inflammatory necroptosis., PMID:40424123
PANoptosis as a Two-Edged Sword in Colorectal Cancer: A Pathogenic Mechanism and Therapeutic Opportunity., PMID:40422233
RIPK1: A Promising Target for Intervention Neuroinflammation., PMID:40418439
Therapeutic potential of young plasma in reversing age-related liver inflammation via modulation of NLRP3 inflammasome and necroptosis., PMID:40418410
Ca2+ transfer via enhancing ER-Mito coupling contributed to BDE-47- induced hippocampal neuronal necroptosis and cognitive dysfunction., PMID:40412245
RIPK3-MLKL dependent necroptosis mediates depressive-like behavior by facilitating neuroinflammation., PMID:40408995
Caspase-8 drove apoptosis of BMECs to promote neutrophil infiltration and DE205B clearance in meningitis., PMID:40408993
Ficolin-3 Activates Complement and Triggers Necroptosis in Cholangiocarcinoma Cells via the RIPK1/RIPK3/MLKL Signaling Pathway., PMID:40407231
Combined Analysis of Network Toxicology and Multiomics Revealed the Potential Mechanism of 6PPDQ-Induced Hepatotoxicity in Mice., PMID:40387457
Exploring the Anticancer Potential of Lamivudine-Loaded Polymeric Nanoparticles: In Vitro Cytotoxicity, Tissue Deposition, Biochemical Impact In Vivo, and Molecular Simulations Analysis., PMID:40384113
Deoxypodophyllotoxin inhibited the growth of malignant pleural mesothelioma by inducing necroptosis and mitotic catastrophe., PMID:40378591
The Discovery of Bridged Benzoazepine Amides as Selective Allosteric Modulators of RIPK1., PMID:40365380
Empagliflozin attenuates DOX-induced cardiotoxicity by inhibiting RIPK1-mediated endoplasmic reticulum stress and autophagy., PMID:40350043
AAV2-driven endothelin induces chronic reduced retinal blood flow/retinal ganglion cell loss in rats., PMID:40345829
Synthesis and characterization of a new Carbon-11 labeled positron emission tomography radiotracer for RIPK1 neuroimaging., PMID:40345137
MiR-214-3p targets RIPK1 to regulate pyroptosis and vascular endothelial function in diabetic ketoacidosis: mechanistic insights., PMID:40339772
Resting-State fMRI and Post-Ischemic Stroke Functional Recovery: Unraveling Causality and Predicting Therapeutic Targets., PMID:40332106
Identification of RIPK3 as a target of flavonoids for anti-necroptosis in vitro., PMID:40328155
Ferroptosis and necroptosis may be involved in the formation and progression of hydrofluoric acid burn wounds: Results from an RNA-Seq analysis., PMID:40327971
[Disulfiram alleviates cardiac hypertrophic injury by inhibiting TAK1-mediated PANoptosis]., PMID:40326066
Lactoferrin Alleviates LPS-Induced Oxidative Stress and Necroptosis in Liver by Promoting Mitophagy., PMID:40323104
Theaflavin suppresses necroptosis by attenuating RIPK1-RIPK3-MLKL signaling and mitigates cisplatin-induced kidney injury in mice., PMID:40318271
Understanding TAK1 deficiency in microglia: Dual mechanisms for photoreceptor protection in a mouse model of retinitis pigmentosa., PMID:40314985
Nano-selenium alleviates tetrabromobisphenol A induced PANoptosis in carp gill tissue by inhibiting TLR4/MyD88/NF-κB pathway., PMID:40311953
High fat and high cholesterol diet induced cognitive impairment in GSDMD knockout mice via the compensatory activation of apoptosis pathway., PMID:40311940
The extract of chrysanthemum flos mitigates post-stroke sarcopenia by inhibiting PANoptosis and restoring muscle homeostasis., PMID:40311590
Utilizing bioinformatics to identify biomarkers and analyze their expression in relation to immune cell ratios in femoral head necrosis., PMID:40308566
RIPK1 ablation in T cells results in spontaneous enteropathy and TNF-driven villus atrophy., PMID:40307618
Bardoxolone Derivatives as Novel Pseudo-Natural Necroptosis Inhibitors by Destabilizing HSP90 Client Proteins., PMID:40307003
RIPK1/RIPK3/MLKL Necrosome Contributes to the Sepsis-Induced Cardiorenal Necroptotic Inflammatory Injury and Mortality., PMID:40296630
Analysis of the Histopathological Characteristics and Expression of RIPK1 and NF- κB in Cervical Cancer in Kumasi, Ghana., PMID:40289006
Cyclooxygenase-2/Prostaglandin E2 Pathway Facilitates Infectious Bronchitis Virus-Induced Necroptosis in Chicken Macrophages, a Caspase-Independent Cell Death., PMID:40284946
BMAL1-downregulation drives PANoptosis and the osteogenic differentiation impairment of PDLSCs by ERK/AP-1 signaling pathway., PMID:40259757
Caspase-independent cell death in lung cancer: from mechanisms to clinical applications., PMID:40257494
Geniposide protects against cerebral ischemic injury by targeting SOX2/RIPK1 axis., PMID:40257488
The mitochondrial dysfunction regulated by JAK2/STAT3 pathway leads to the necroptosis in the renal cells under patulin exposure., PMID:40249973
For research use only. Not for human or drug use.
