Catalog No.
YHG57901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser2-Ile118
Predicted molecular weight
14.76 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13541
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PHAS-I, eIF4E-binding protein 1, EIF4EBP1, Eukaryotic translation initiation factor 4E-binding protein 1, 4E-BP1, Phosphorylated heat- and acid-stable protein regulated by insulin 1
NME2 modulates HCC progression through 4EBP1 phosphorylation and autophagy regulation independent of mTOR., PMID:40489759
The role of E2F1 in promoting EIF4EBP1 transcription in cryptorchid mice: association with autophagy in germ cells., PMID:40486678
Development and application of a targeted phosphoproteomics method for analysing the mTOR pathway dynamics in zebrafish PAC2 cell line., PMID:40466985
4E-BP1-dependent translation in microglia controls mechanical hypersensitivity in male and female mice., PMID:40454470
Integrating metabolomics and transcriptomics to analyze differences in muscle mass and flavor formation in Gayal and yellow cattle., PMID:40438416
Molecular correlates of glycine receptor activity in human β cells., PMID:40258441
Hepatic MC3R is a regulator of lipid droplet autophagy and liver steatosis., PMID:40247435
The Effect of Valine on the Synthesis of α-Casein in MAC-T Cells and the Expression and Phosphorylation of Genes Related to the mTOR Signaling Pathway., PMID:40243924
TFEB and TFE3 regulate STING1-dependent immune responses by controlling type I interferon signaling., PMID:40195022
Exosomal 4EBP1 promotes head and neck cancer progression via regulating mitochondrial fission., PMID:40188596
Nutritional modulation of the mTORC1 pathway in muscle: differential effect according to muscle and sex., PMID:40184212
Hippocampal Inhibitory Interneuron-Specific DREADDs Treatment Alters mTORC1-4E-BP Signaling and Impairs Memory Formation., PMID:40123570
Six-hour hypoxia-induced protein degradation in M. gastrocnemius of 24-day-old mice by activating FOXO1 and suppressing AKT-mTORC1., PMID:40094441
Autophagy regulates cellular senescence by mediating the degradation of CDKN1A/p21 and CDKN2A/p16 through SQSTM1/p62-mediated selective autophagy in myxomatous mitral valve degeneration., PMID:39988732
TPD52 (isoform 3) promotes resistance to mTOR-targeted inhibitors by regulating c-Myc, PTEN, and direct activation of 4E-BP1 in LNCaP androgen-dependent cells., PMID:39983549
Isoliquiritigenin, an Extract from Licorice, Attenuates Dexamethasone-Induced Muscle Atrophy via Akt/mTOR Pathway., PMID:39981829
Buddleoside alleviates nonalcoholic steatohepatitis by targeting the AMPK-TFEB signaling pathway., PMID:39936600
Translational regulation of SND1 governs endothelial homeostasis during stress., PMID:39895626
Inhibition of Retinal Neovascularization by BEZ235: Targeting the Akt/4EBP1/Cyclin D1 Pathway in Endothelial Cells., PMID:39888634
Limiting cap-dependent translation increases 20S proteasomal degradation and protects the proteomic integrity in autophagy-deficient skeletal muscle., PMID:39878121
Small-molecule modulators of B56-PP2A restore 4E-BP function to suppress eIF4E-dependent translation in cancer cells., PMID:39869680
Transcriptomic Evidence Reveals the Dysfunctional Mechanism of Synaptic Plasticity Control in ASD., PMID:39858558
Poststroke hyperglycemia dysregulates cap-dependent translation in neural cells., PMID:39719167
AMPK protects proximal tubular epithelial cells from lysosomal dysfunction and dedifferentiation induced by lipotoxicity., PMID:39675352
Quantitative Top-down Proteomics Revealed Kinase Inhibitor-Induced Proteoform-Level Changes in Cancer Cells., PMID:39620430
The ataxia-telangiectasia disease protein ATM controls vesicular protein secretion via CHGA and microtubule dynamics via CRMP5., PMID:39615799
Nuclear mTORC1 Live-Cell Sensor nTORSEL Reports Differential Nuclear mTORC1 Activity in Cell Lines., PMID:39596185
Effects of L-leucine and sodium acetate on milk protein synthesis under heat stress conditions in bovine mammary epithelial cells in vitro., PMID:39571500
The Bi-steric Inhibitor RMC-5552 Reduces mTORC1 Signaling and Growth in Lymphangioleiomyomatosis., PMID:39531634
Activation of platelet-derived growth factor receptors regulate connective tissue growth factor protein levels via the AKT pathway in malignant mesothelioma cells., PMID:39441675
Hyperactive mTORC1/4EBP1 signaling dysregulates proteostasis and accelerates cardiac aging., PMID:39379739
Small-molecule mediated MuRF1 inhibition protects from doxorubicin-induced cardiac atrophy and contractile dysfunction., PMID:39366504
Identification and validation of autophagy‑related genes in hypertrophic cardiomyopathy., PMID:39355520
Loss-of-Function Variants in CUL3 Cause a Syndromic Neurodevelopmental Disorder., PMID:39301775
Sorafenib-mediated cleavage of p62 initiates cellular senescence as a mechanism to evade its anti-hepatocellular carcinoma efficacy., PMID:39232218
Transient Inhibition of Translation Improves Cardiac Function After Ischemia/Reperfusion by Attenuating the Inflammatory Response., PMID:39206545
Effect of Oral Skim Milk Administration on Skeletal Muscle Protein Synthesis after Total Gastrectomy in Rat., PMID:39125271
eIF4E-independent translation is largely eIF3d-dependent., PMID:39107322
Mmu_circ_0005373 and hsa_circ_0136255 participate in the pulmonary fibrosis of systemic sclerosis., PMID:39053227
GRP78 inhibitor YUM70 upregulates 4E-BP1 and suppresses c-MYC expression and viability of oncogenic c-MYC tumors., PMID:38991376
Identification of new targets for glioblastoma therapy based on a DNA expression microarray., PMID:38981212
Tumoral EIF4EBP1 regulates the crosstalk between tumor-associated macrophages and tumor cells in MRTK., PMID:38944176
[Clinical Significance of USP5 Expression Level in Acute Myeloid Leukemia and Its Regulatory Effects on AKT/mTOR/4EBP1 Signaling Pathway]., PMID:38926952
4EBP1-mediated SLC7A11 protein synthesis restrains ferroptosis triggered by MEK inhibitors in advanced ovarian cancer., PMID:38842940
Retinoic acid signalling inhibits myogenesis by blocking MYOD translation in pig skeletal muscle cells., PMID:38753962
Inhibition of the rapamycin-insensitive mTORC1 /4E-BP1 axis attenuates TGF-β1-induced fibrotic response in human Tenon's fibroblasts., PMID:38750784
mTORC1 regulates cell survival under glucose starvation through 4EBP1/2-mediated translational reprogramming of fatty acid metabolism., PMID:38744825
Unexpected roles for AMPK in the suppression of autophagy and the reactivation of MTORC1 signaling during prolonged amino acid deprivation., PMID:38744665
PTEN and P-4E-BP1 might be associated with postoperative recurrence of rectal cancer patients undergoing concurrent radiochemotherapy., PMID:38741069
Assessment of Mammalian Target of Rapamycin Pathway Activation in Basal Cell Carcinoma as a New Therapeutic Approach., PMID:38648034
For research use only. Not for human or drug use.
