Catalog No.
YHG57701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala2353-Met2644
Predicted molecular weight
35.90 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13535
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
FRP1, Serine/threonine-protein kinase ATR, FRAP-related protein 1, ATR, Ataxia telangiectasia and Rad3-related protein
Therapeutic potential of BOLD-100, a GRP78 inhibitor, enhanced by ATR inhibition in pancreatic ductal adenocarcinoma., PMID:40514666
Interfacial engineering-tailored Mn-clay-based nanozyme for glyphosate laccase-amplified sensing and inhibitor screening., PMID:40513292
Serum-Based Assessment of Alopecia Areata Response to Treatment Using ATR-FTIR Spectroscopy., PMID:40506941
RNA transcripts regulate G-quadruplex landscapes through G-loop formation., PMID:40504899
Quantitation of Tuvusertib (M1774) in Human Plasma by LC-MS/MS., PMID:40485138
Checkpoint activation and recovery: regulation of the 9-1-1 axis by the PP2A phosphatase., PMID:40483899
A medicinal chemistry perspective on ATR: Current status and future directions., PMID:40479897
Histone deacetylase inhibitors target DNA replication regulators and replication stress in Ewing sarcoma cells., PMID:40478628
DNA polymerase beta expression in head & neck cancer modulates the poly(ADP-ribose)-mediated replication checkpoint., PMID:40472742
The role of organic matter and extracellular polymeric substances of various municipal sludges on their rheology and dewaterability., PMID:40472604
[Mechanistic study on low expression of Ace2 gene activated senescence-related signals and promoted the progression of silicotic fibrosis in mice]., PMID:40468507
Understanding freezing-induced changes in the protein and fat phases of aged Gouda cheese using Fourier transform infrared and Raman spectroscopy., PMID:40467239
Oxidative Base Damage to Telomeres Sensitizes Cancer Cells to ATR Inhibition., PMID:40463079
ATRX ADD domain is a versatile module for recognizing macroH2A, H3, and beyond., PMID:40443347
Innovative unsaturated polyurethane for cardiac regeneration: Enhancing cytocompatibility and gene expression through gelatin modification., PMID:40441578
Heat shock transcription factor 2 reduces mitochondrial pathway apoptosis in intestinal epithelial cells by inhibiting the increase in mitochondrial membrane permeability in ulcerative colitis., PMID:40440295
Bioprospecting potential genetic biomarkers of gallbladder cancer., PMID:40439781
Microtracer-Based Assessment of the Mass Balance, Pharmacokinetics, and Excretion of [14C]Berzosertib, an Intravenous ATR Inhibitor, in Patients With Advanced Solid Tumors: A Phase 1 Study., PMID:40437704
Co-inhibition of Notch1 and ChK1 triggers genomic instability and melanoma cell death increasing the lifespan of mice bearing melanoma brain metastasis., PMID:40437523
Hemoglobin Disorders Associated with Neurological Impairment: First Report of ATR-X Syndrome and Recessive Congenital Methemoglobinemia Type II in Tunisia., PMID:40429944
ATR Deficiency Impairs DNA Damage Repair and Accelerates Cellular Senescence in Bovine Mammary Epithelial Cells, Leading to Lactation Dysfunction., PMID:40427296
Fate of egg white proteins in aged painting layers by UV-induced processes: a comprehensive proteomic study., PMID:40424789
Cancer Vulnerabilities Through Targeting the ATR/Chk1 and ATM/Chk2 Axes in the Context of DNA Damage., PMID:40422251
Primary cilium restricts TGF-β/SMAD signaling induced RIBEs in the co-culture model., PMID:40412783
Synchrotron macro-ATR-FTIR: a powerful technique for analyzing changes in plant cell chemical composition after surfactant exposure., PMID:40408558
Disruption of ATR Signaling by Epstein-Barr Virus Latent Membrane Protein 1 Sensitizes Nasopharyngeal Carcinoma Cells to Cisplatin., PMID:40407079
B(reath)e water my friend: hydration of pulmonary surfactant layers as analyzed by fourier transform-infrared spectroscopy., PMID:40404002
Comparative analysis of pH shift-induced aggregation in IgG subclasses: Unveiling distinct pathways, mechanisms, and kinetics., PMID:40403800
Photobiomodulation as a strategy to enhance argan oil permeation across diverse hair types., PMID:40403470
Feasibility of non-invasive measurement of cardiac biomarkers using mid-infrared spectroscopy: finite element analysis and experimental validation., PMID:40401368
Analytical and biological assessment of Magnolia champaca L. stem bark: Integrating ATR-FTIR, GC-MS, thrombolytic activity, brine shrimp lethality and molecular docking., PMID:40390495
ANP32E drives vulnerability to ATR inhibitors by inducing R-loops-dependent transcription replication conflicts in triple negative breast cancer., PMID:40382323
Bond preservation in caries-affected dentin restored with acrylamide-based adhesives., PMID:40379529
Accurate forensic identification of asphyxial deaths: Differentiating strangulation and drowning using ATR-FTIR spectroscopy., PMID:40379415
Nucleosomes represent a crucial target for the intra-S phase checkpoint in response to replication stress., PMID:40378213
Impact of propylene glycol, menthol:thymol deep eutectic solvent, and their blends on the structure and molecular mobility of stratum corneum components., PMID:40368001
Genetic insight into lung neuroendocrine tumors: Notch and Wnt signaling pathways as potential targets., PMID:40361150
A PP2A-mtATR-tBid axis links DNA damage-induced CIP2A degradation to apoptotic dormancy and therapeutic resistance in PDAC., PMID:40354992
[Clinical feature and genetic analysis of a case of X-linked alpha-thalassemia mental retardation syndrome neonate caused by ATRX gene variant and literature review]., PMID:40350394
The cold immunological landscape of ATM-deficient cancers., PMID:40350205
Combined exposure to atrazine and phoxim exacerbated the alterations of enzyme activity and abnormal gene expression in earthworms (Eisenia fetida)., PMID:40345462
Comparative in vivo toxicology of ATR inhibitors ceralasertib, elimusertib, and berzosertib alone and in combination with ionizing radiation., PMID:40339611
Attenuated total reflection mid-infrared spectroscopy to screen Austrian and French wheat from multiple years for deoxynivalenol., PMID:40339401
Multiomics analysis unveils an inosine-sensitive DNA damage response in neurogenic bladder after spinal cord injury., PMID:40338665
Volatile oil of Acori tatarinowii rhizoma: potential candidate drugs for mitigating dementia., PMID:40337511
Corrigendum: Inhibition of ATM or ATR in combination with hypo-fractionated radiotherapy leads to a different immunophenotype on transcript and protein level in HNSCC., PMID:40337061
MS CETSA deep functional proteomics uncovers DNA repair programs leading to gemcitabine resistance., PMID:40335468
Phosphate modified zerovalent iron enhances the interfacial hydrogen bond mediated adhesion and inactivation of Escherichia coli., PMID:40334322
Genetic diversity, virulence genes, antimicrobial resistance genes, and antimicrobial susceptibility of group B Streptococcus (GBS) associated with mass mortalities of cultured Nile tilapia in Brazil., PMID:40324602
Therapy-induced senescence of glioblastoma cells is determined by the p21CIP1-CDK1/2 axis and does not require activation of DREAM., PMID:40319068
For research use only. Not for human or drug use.
