Catalog No.
YHG57101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser20-Val176
Predicted molecular weight
20.49 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13519
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
OFQ, PPNOC, Prepronociceptin, PNOC, Orphanin FQ
Identification of a stress-sensitive endogenous opioid-containing neuronal population in the paranigral ventral tegmental area., PMID:40291662
Septo-hypothalamic regulation of binge-like alcohol consumption by the nociceptin system., PMID:40153436
Developmental and Adult Striatal Patterning of Nociceptin Ligand Marks Striosomal Population With Direct Dopamine Projections., PMID:39656141
Development of a genetically encoded sensor for probing endogenous nociceptin opioid peptide release., PMID:38918403
GABAergic disinhibition from the BNST to PNOCARC neurons promotes HFD-induced hyperphagia., PMID:38865247
Differentially Expressed Genes Involved in Primary Resistance to Immunotherapy in Patients with Advanced-Stage Pulmonary Cancer., PMID:38396726
Dorsoventral Arrangement of Lateral Hypothalamus Populations in the Mouse Hypothalamus: a Prosomeric Genoarchitectonic Analysis., PMID:36357614
Rostromedial tegmental nucleus nociceptin/orphanin FQ (N/OFQ) signaling regulates anxiety- and depression-like behaviors in alcohol withdrawn rats., PMID:36329156
HypoMap-a unified single-cell gene expression atlas of the murine hypothalamus., PMID:36266547
Alzheimer's disease large-scale gene expression portrait identifies exercise as the top theoretical treatment., PMID:36229643
[Exploring and bioinformatics analysis of differentially expressed genes in bronchial asthma]., PMID:34895422
The Expression Pattern of Genes Related to Melanogenesis and Endogenous Opioids in Psoriasis., PMID:34884858
Bioinformatics-based study to identify immune infiltration and inflammatory-related hub genes as biomarkers for the treatment of rheumatoid arthritis., PMID:34477936
Analysis of the transcriptional activity of genes of neuropeptides and their receptors in the blood of patients with thyroid pathology., PMID:34104248
Differential DNA methylation and mRNA transcription in gingival tissues in periodontal health and disease., PMID:34101221
PNOC Expressed by B Cells in Cholangiocarcinoma Was Survival Related and LAIR2 Could Be a T Cell Exhaustion Biomarker in Tumor Microenvironment: Characterization of Immune Microenvironment Combining Single-Cell and Bulk Sequencing Technology., PMID:33841428
Pituitary neuropeptides and B lymphocyte function., PMID:33817820
Genetic determinants of daytime napping and effects on cardiometabolic health., PMID:33568662
Development of a prognostic model based on an immunogenomic landscape analysis of medulloblastoma., PMID:33345275
Establishment of a Colorectal Cancer-Related MicroRNA-mRNA Regulatory Network by Microarray and Bioinformatics., PMID:33193642
Prepronociceptin-Expressing Neurons in the Extended Amygdala Encode and Promote Rapid Arousal Responses to Motivationally Salient Stimuli., PMID:33176134
Nerve impulse transmission pathway-focused genes expression analysis in patients with primary hypothyroidism and autoimmune thyroiditis., PMID:32597152
Maf and Mafb control mouse pallial interneuron fate and maturation through neuropsychiatric disease gene regulation., PMID:32452758
Selective alterations in endogenous opioid system genes expression in rats selected for high ethanol intake during adolescence., PMID:32442753
Helicid Reverses Lipopolysaccharide-Induced Inflammation and Promotes GDNF Levels in C6 Glioma Cells through Modulation of Prepronociceptin., PMID:32329965
PNOCARC Neurons Promote Hyperphagia and Obesity upon High-Fat-Diet Feeding., PMID:32302532
Opioid Peptides and Their Receptors in Chickens: Structure, Functionality, and Tissue Distribution., PMID:32217145
Evolution of proopiomelanocortin., PMID:31421696
A Paranigral VTA Nociceptin Circuit that Constrains Motivation for Reward., PMID:31348890
Transcriptional profile of spinal dynorphin-lineage interneurons in the developing mouse., PMID:31166300
Central Amygdala Prepronociceptin-Expressing Neurons Mediate Palatable Food Consumption and Reward., PMID:31029403
Analysis of key genes and micro-RNA-mRNA regulatory networks in women with ulcerative interstitial cystitis/pain bladder syndrome., PMID:30456462
Gene expression and neurochemical characterization of the rostromedial tegmental nucleus (RMTg) in rats and mice., PMID:30302539
Involvement of microglial cells in the antinociceptive effects of metamizol in a mouse model of neuropathic pain., PMID:30267794
Identification of key genes related to high-risk gastrointestinal stromal tumors using bioinformatics analysis., PMID:29578181
Nociceptin and the NOP receptor in aversive learning in mice., PMID:29102248
Affection of Comt1 genetype on anxiety and nociceptive sensitivity: an Ego-network analysis approach., PMID:28969474
A toolkit for Nannochloropsis oceanica CCMP1779 enables gene stacking and genetic engineering of the eicosapentaenoic acid pathway for enhanced long-chain polyunsaturated fatty acid production., PMID:28605577
Association of maternal and infant variants in PNOC and COMT genes with neonatal abstinence syndrome severity., PMID:27983768
Variants of opioid system genes are associated with non-dependent opioid use and heroin dependence., PMID:27664554
Repeated nicotine exposure modulates prodynorphin and pronociceptin levels in the reward pathway., PMID:27430399
Repeated exposure to neurotoxic levels of chlorpyrifos alters hippocampal expression of neurotrophins and neuropeptides., PMID:26775027
60 YEARS OF POMC: POMC: an evolutionary perspective., PMID:26671895
Variations in opioid receptor genes in neonatal abstinence syndrome., PMID:26233486
Gene-Expression Profiles in Generalized Aggressive Periodontitis: A Gene Network-Based Microarray Analysis., PMID:26136121
Delta opioid agonists: a concise update on potential therapeutic applications., PMID:25726896
Molecular detection of the blood meal source of sand flies (Diptera: Psychodidae) in a transmission area of American cutaneous leishmaniasis, Paraná State, Brazil., PMID:25530542
Bioactivity studies on atypical natural opioid hexapeptides processed from proenkephalin (PENK) precursor polypeptides., PMID:24947211
Inflammatory mediators influence the expression of nociceptin and its receptor in human whole blood cultures., PMID:24066107
Nociceptin receptor signaling in sympathetic neurons from septic rats., PMID:23608620
For research use only. Not for human or drug use.
