Catalog No.
YHG56801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gln22-Trp395
Predicted molecular weight
44.98 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13510
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PHP32, ASAH1, ACDase, AC, N-acylethanolamine hydrolase ASAH1, Acid CDase, Acylsphingosine deacylase, N-acylsphingosine amidohydrolase, Putative 32 kDa heart protein, ASAH, Acid ceramidase
JuJing formula protects retinal by regulating Nrf2/HO-1 pathways and sphingolipid rheostat and its key protein levels on liver-kidney Yin deficient retinal damage mice., PMID:40473146
[Genetic analysis of a fetus with Farber lipogranulomatosis caused by ASAH1 gene variant]., PMID:40350404
Clinical correlations of plasma sphingosine-1-phosphate and sphingolipid key enzymes in severe dengue using laboratory and machine learning approach., PMID:40306535
Protein signatures of feed restriction and spontaneous lipolysis in ewe's skimmed milk., PMID:40221030
Bisphosphonates Trigger Anti-Ageing Effects Across Multiple Cell Types and Protect Against Senescence., PMID:40196558
High temperature ameliorates high-fat diet-induced obesity by promoting ceramide breakdown in skeletal muscle tissue., PMID:39872144
Ablation of Hepatic Asah1 Gene Disrupts Hepatic Lipid Homeostasis and Promotes Fibrotic Nonalcoholic Steatohepatitis in Mice., PMID:39719015
Effect of the SGLT2 inhibitor ipragliflozin on the expression of genes that regulate skin function., PMID:39710589
Cardiac dysfunction and altered gene expression in acid ceramidase-deficient mice., PMID:39665198
Acid ceramidase controls proteasome inhibitor resistance and is a novel therapeutic target for the treatment of relapsed/refractory multiple myeloma., PMID:39633543
Proteomic and N-glycosylation analysis of fertile egg white during storage and incubation in chickens., PMID:39608286
[Therapeutic perspectives for lysosomal storage disorders caused by acid ceramidase deficiency]., PMID:39555879
Overexpression of the β-Subunit of Acid Ceramidase in the Epidermis of Mice Provokes Atopic Dermatitis-like Skin Symptoms., PMID:39201426
Alkaline ceramidase 1-mediated platelet ceramide catabolism mitigates vascular inflammation and abdominal aortic aneurysm formation., PMID:39196139
Ceramide metabolism alterations contribute to Tumor Necrosis Factor-induced melanoma dedifferentiation and predict resistance to immune checkpoint inhibitors in advanced melanoma patients., PMID:39136013
Hematopoietic stem cell transplantation leads to biochemical and functional correction in two mouse models of acid ceramidase deficiency., PMID:39108096
ASAH1 facilitates TNBC by DUSP5 suppression-driven activation of MAP kinase pathway and represents a therapeutic vulnerability., PMID:38926346
MCL restrained ROS/AKT/ASAH1 pathway to therapy tamoxifen resistance breast cancer by stabilizing NRF2., PMID:38924190
Lipid metabolism-related genes are involved in the occurrence of asthma and regulate the immune microenvironment., PMID:38297226
Targeting acid ceramidase enhances antitumor immune response in colorectal cancer., PMID:38142035
ASAH1 Variants Causing Spinal Muscular Atrophy Phenotype., PMID:38079070
Acid ceramidase regulates innate immune memory., PMID:37995184
Functional analysis of a novel splice site variant in the ASAH1 gene., PMID:37962265
Proteometabolomics of initial and recurrent glioblastoma highlights an increased immune cell signature with altered lipid metabolism., PMID:37882631
Benign and Malignant Tumors of the Pineal Region., PMID:37452938
Expression of Ceramide-Metabolizing Enzymes in the Heart Adipose Tissue of Cardiovascular Disease Patients., PMID:37298446
Induction of Inflammation Disrupts the Negative Interplay between STING and S1P Axis That Is Observed during Physiological Conditions in the Lung., PMID:37176007
Integrated metabolomics, network pharmacology, and molecular docking to reveal the mechanisms of Isodon excisoides against drug-induced liver injury., PMID:37158044
Distinct Changes in Placental Ceramide Metabolism Characterize Type 1 and 2 Diabetic Pregnancies with Fetal Macrosomia or Preeclampsia., PMID:36979912
Upregulation of acid ceramidase contributes to tumor progression in tuberous sclerosis complex., PMID:36927688
Contribution of Hepatic Steatosis-Intensified Extracellular Vesicle Release to Aggravated Inflammatory Endothelial Injury in Liver-Specific Asah1 Gene Knockout Mice., PMID:36638912
Proteomic profiling of urinary small extracellular vesicles in children with pneumonia: a pilot study., PMID:36635400
iTRAQ-Based Proteomic Analysis of APP Transgenic Mouse Urine Exosomes., PMID:36614115
Cell-intrinsic ceramides determine T cell function during melanoma progression., PMID:36426850
Regulation of exosome release by lysosomal acid ceramidase in coronary arterial endothelial cells: Role of TRPML1 channel., PMID:36368874
Impaired autophagic flux and dedifferentiation in podocytes lacking Asah1 gene: Role of lysosomal TRPML1 channel., PMID:36302466
Identification of Genomic Regions and Candidate Genes Associated with Body Weight and Body Conformation Traits in Karachai Goats., PMID:36292658
Inhibition of inflammasome activation via sphingolipid pathway in acute lung injury by Huanglian Jiedu decoction: An integrative pharmacology approach., PMID:36202056
Acid ceramidase targeting pyruvate kinase affected trypsinogen activation in acute pancreatitis., PMID:36068514
Dysregulated sphingolipid metabolism and autophagy in granulosa cells of women with endometriosis., PMID:35992117
rAAV-mediated over-expression of acid ceramidase prevents retinopathy in a mouse model of Farber lipogranulomatosis., PMID:35902747
Targeting Acid Ceramidase Inhibits Glioblastoma Cell Migration through Decreased AKT Signaling., PMID:35741006
Epidermal 1-O-acylceramides appear with the establishment of the water permeability barrier in mice and are produced by maturating keratinocytes., PMID:35318678
Inhibition of ceramide accumulation in AdipoR1-/- mice increases photoreceptor survival and improves vision., PMID:35015730
α-Galactosidase a Deficiency in Fabry Disease Leads to Extensive Dysregulated Cellular Signaling Pathways in Human Podocytes., PMID:34768768
Inhibition of acid ceramidase elicits mitochondrial dysfunction and oxidative stress in pancreatic cancer cells., PMID:34459070
Skin Mast Cell-Driven Ceramides Drive Early Apoptosis in Pre-Symptomatic Eczema in Mice., PMID:34360617
Alterations of lipid metabolism provide serologic biomarkers for the detection of asymptomatic versus symptomatic COVID-19 patients., PMID:34244584
A case of ASAH1-related pure SMA evolving into adult-onset Farber disease., PMID:34240417
Regulatory role of mammalian target of rapamycin signaling in exosome secretion and osteogenic changes in smooth muscle cells lacking acid ceramidase gene., PMID:34143450
For research use only. Not for human or drug use.
