Catalog No.
YHG56101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Val122
Predicted molecular weight
15.99 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13501
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
OSIL, EBIAP, Sequestosome-1, Ubiquitin-binding protein p62, ORCA, EBI3-associated protein of 60 kDa, p60, SQSTM1, Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa
Macrophage TRIM21 knockout inhibits septic acute lung injury by downregulating autophagy regulator protein ubiquitination., PMID:40509575
TYROBP modulates NFκB phosphorylation and SQSTM1 expression in macrophages during Brucella Abortus LPS infection., PMID:40505588
Identification of autophagy-related genes in intestinal ischemia-reperfusion injury and their role in immune infiltration., PMID:40491449
Early proteasome downregulation and dysfunction drive proteostasis failure in Alzheimer's disease., PMID:40488453
Novel HSPB8 mutations in severe early-onset myopathy with involvement of respiratory and cardiac muscles cause proteostasis defects in cell models., PMID:40467930
Pseudorabies virus gM protein and herpesvirus homologs block selective autophagy to enhance viral replication., PMID:40462306
Autophagy hub-protein p62 orchestrates oxidative, endoplasmic reticulum stress, and inflammatory responses post-ischemia, exacerbating stroke outcome., PMID:40460555
SFTSV NSs degrades SAFA via autophagy to suppress SAFA-dependent antiviral response., PMID:40460159
CB5712809, a novel Keap1 inhibitor upregulates SQSTM1/p62 mediated Nrf2 activation to induce cell death in colon cancer cells., PMID:40451905
Inhibiting effect of LIPUS on epithelial-mesenchymal transition in lens epithelial cells., PMID:40449868
Expression and Diagnostic Value of Nrf2 and p62 in Cervical Squamous Cell Carcinoma and Intraepithelial Lesions., PMID:40438129
RETREG1-mediated reticulophagy is activated by an ATF4-CEBPG/C/EBPγ heterodimer and confers protection against lipotoxicity., PMID:40437698
Human endogenous retrovirus W family envelope protein (ERVWE1) regulates macroautophagy activation and micromitophagy inhibition via NOXA1 in schizophrenia., PMID:40419114
Defective autophagy in a fibroin secretion-deficient silkworm mutant., PMID:40413758
Evidence of an unprecedented cytoplasmic function of DDX11, the Warsaw breakage syndrome DNA helicase, in regulating autophagy., PMID:40413757
Unveiling EXOC4/SEC8: a key player in enhancing antiviral immunity by inhibiting the FBXL19-STING1-SQSTM1 signaling axis., PMID:40413753
Evaluation of aggrephagy markers in myofibrillar myopathies., PMID:40413523
Oscillatory shear stress activates integrin β3, blocking autophagic flux in endothelial cells and promoting endothelial cells senescence., PMID:40412535
Mechanical signal modulates prostate cancer immune escape by USP8-mediated ubiquitination-dependent degradation of PD-L1 and MHC-1., PMID:40410130
ELV-N34, RvD6-Isomer, or NPD1 Halt Replication of SARS-CoV-2 Omicron BA.5 Virus in Human Lung and Nasal Cells., PMID:40407038
Autophagic degradation of SQSTM1 enables fibroblast activation to accelerate wound healing., PMID:40400126
Autophagy and exosome dynamics in Radiation-Induced pulmonary fibrosis: the critical role of TRIB3., PMID:40399917
A redox-independent stress response mediated by phase-separated SQSTM1/p62., PMID:40395541
The selective autophagic degradation of avian metapneumovirus subgroup C M2-2 protein via SQSTM1 suppresses viral replication., PMID:40395539
S-palmitoylation coordinates the trafficking of ATG9A to mediate autophagy initiation., PMID:40394978
mTOR inhibition in Q175 Huntington's disease model mice facilitates neuronal autophagy and mutant huntingtin clearance., PMID:40392702
TRIM16 mediates secretory autophagy in head and neck cancer-associated fibroblasts., PMID:40383937
Autophagy-related gene SQSTM1 predicts the prognosis of hepatocellular carcinoma., PMID:40378566
The p.R321C mutation in the p62 protein is associated with abnormalities in the central nervous system., PMID:40374720
Autophagy- and oxidative stress-related protein deregulation mediated by extracellular vesicles of human MJD/SCA3 iPSC-derived neuroepithelial stem cells and differentiated neural cultures., PMID:40374597
Autophagy Impairment-Derived SQSTM1 Accumulation Promotes Ferroptosis in Corneal Epithelial Cells Through ACSL4 in Dry Eye., PMID:40358583
[Inhibition of ISO-induced hypertrophy and damage in H9c2 cells by total saponins from Ginseng Radix et Rhizoma and Notoginseng Radix et Rhizoma via promoting autophagy]., PMID:40350876
Short-chain polyphosphates induce tau fibrillation and neurotoxicity in human iPSC-derived retinal neurons., PMID:40346074
SIRT5-mediated desuccinylation of the porcine deltacoronavirus M protein drives pexophagy to enhance viral proliferation., PMID:40344161
METTL3-dependent m6A modification of SNAP29 induces "autophagy-mitochondrial crisis" in the ischemic microenvironment after soft tissue transplantation., PMID:40340690
SFTSV induces liver ferroptosis through m6A-related ferritinophagy., PMID:40340535
p97/VCP is required for piecemeal autophagy of aggresomes., PMID:40335532
Reduced Palmitoylation of SQSTM1/p62 in Huntington Disease Is Associated With Impaired Autophagy., PMID:40326774
Poldip2 Aggravates inflammation in diabetic retinopathy by impairing mitophagy via the AMPK/ULK1/Pink1 pathway., PMID:40320136
The interactome of tau phosphorylated at T217 in Alzheimer's disease human brain tissue., PMID:40317322
Tooth Loss Leads to Cognitive Impairment and Mitochondrial Disturbance in Wistar Rats., PMID:40311189
An ALS assembly modulator signature in peripheral blood mononuclear cells: implications for ALS pathophysiology, therapeutics, and diagnostics., PMID:40295933
Distinct yet Overlapping Functions of VMP1 and TMEM41B in Modulating Hepatic Lipoprotein Secretion and Autophagy in MASH., PMID:40291711
Perfluorooctanoic acid (PFOA) activates astrogliosis-associated neuroinflammation through ER stress-autophagy axis., PMID:40288163
TDP-43 seeding activity in the olfactory mucosa of patients with amyotrophic lateral sclerosis., PMID:40287755
S-adenosylmethionine inhibits non-small cell lung cancer and enhances chemosensitivity by targeting the P62/NF-κB axis and regulating autophagy and oxidative stress., PMID:40280015
P62 inhibits IL-1β release during Salmonella Typhimurium infection of macrophages., PMID:40276384
Valosin-Containing Protein (VCP/p97) Mediates Neuroendocrine Differentiation in Prostate Cancer Cells Through Pim1 Signaling Inducing Autophagy., PMID:40269472
Sequestosome 1 in Autophagy Regulates a Defense Response of the Striped Stem Borer to the Cry9Aa Protein., PMID:40265649
ATG9 inhibits Rickettsia binding to the host cell surface by blocking the rOmpB-XRCC6/KU70 interaction., PMID:40259479
For research use only. Not for human or drug use.
