Catalog No.
YHG54701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys35-Ser179
Predicted molecular weight
19.18 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13472
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
DNA topoisomerase 3-alpha, TOP3, TOP3A, DNA topoisomerase III alpha
A systematic insight into glycycoumarin as potential IL-8/topo I inhibitor from natural products collected in Taibai mountain based on the combination of in silico and bioassay., PMID:40493282
The low endoribonuclease activity and lack of rNMP preference of human mitochondrial topoisomerase 1 protect against ribonucleotide-dependent deletions., PMID:40479709
Tyrosine and Phenylalanine Activate Neuronal DNA Repair but Exhibit Opposing Effects on Global Transcription and Adult Female Mice Are Resilient to TyrRS/YARS1 Depletion., PMID:40476370
In Silico Approach to Design of New Multi-Targeted Inhibitors Based on Quinoline Ring with Potential Anticancer Properties., PMID:40429764
New Dimethoxyaryl-Sesquiterpene Derivatives with Cytotoxic Activity Against MCF-7 Breast Cancer Cells: From Synthesis to Topoisomerase I/II Inhibition and Cell Death Mechanism Studies., PMID:40429684
Antitumor activity of topoisomerase I targeted by camptothecin 7-propionyl derivatives against ampullary carcinoma., PMID:40403499
A noval identification of 4 systemic sclerosis - interstitial lung disease subgroups using principal component analysis-based cluster analysis., PMID:40399864
A Rare Case of Systemic Sclerosis with Topo I Positivity and Anti-Topoisomerase I (Scl-70) Antibody Negativity., PMID:40387758
Bacterial Topoisomerase I Growth Complementation Assay., PMID:40372634
Expression and One-Step Purification of His-tagged Bacterial Topoisomerase Subunits from Escherichia coli., PMID:40372632
Highly Brominated Quinolines: Synthesis, Characterization, and Investigation of Anticancer Activities Supported by Molecular Dynamics., PMID:40329364
Patulin and Xestoquinol are inhibitors of DNA topoisomerase 1., PMID:40273104
Progesterone Enhances Sensitivity of Ovarian Cancer Cells to SN38 Through Inhibition of Topoisomerase I and Inducing Ferroptosis., PMID:40270435
Deciphering the human TopIIIα activity modulated by Rmi1 using magnetic tweezers., PMID:40266687
Topoisomerase 3b facilitates piRNA biogenesis to promote transposon silencing and germ cell development., PMID:40184251
Fork-barrier-independent roles of topoisomerase I in the ribosomal DNA., PMID:40119707
Rational Design of Bioinspired Lipoprotein System to Improve Penetration in Colorectal Peritoneal Metastases., PMID:40106687
A CPC-shelterin-BTR axis regulates mitotic telomere deprotection., PMID:40097392
TOP1 Priority: Advancing Biomarker-Driven Patient Selection for the Use of ADCs., PMID:40095530
Unveiling the Mechanism of Action of Palmitic Acid, a Human Topoisomerase 1B Inhibitor from the Antarctic Sponge Artemisina plumosa., PMID:40076642
Emerging Role of Natural Topoisomerase Inhibitors as Anticancer agents., PMID:40070141
The prognostic power of anti-topoisomerase I and anti-centromere antibodies in systemic sclerosis - A systematic review of the literature., PMID:40037059
Design, Synthesis and Bioactive Evaluation of Topo I/c-MYC Dual Inhibitors to Inhibit Oral Cancer via Regulating the PI3K/AKT/NF-κB Signaling Pathway., PMID:40005202
Topoisomerase 1 is required for the development and function of thymus., PMID:39959339
Drosophila Topoisomerase 3β binds to mRNAs in vivo, contributes to their localization and stability, and counteracts premature aging., PMID:39932982
The BLM-TOP3A-RMI1-RMI2 proximity map reveals that RAD54L2 suppresses sister chromatid exchanges., PMID:39870965
Synthesis, Structural Modification, and Antismall Cell Lung Cancer Activity of 3-Arylisoquinolines with Dual Inhibitory Activity on Topoisomerase I and II., PMID:39844445
Mitochondria-Related Genome-Wide Mendelian Randomization Identifies Putatively Causal Genes for Neurodegenerative Diseases., PMID:39838927
An overview of small-molecule agents for the treatment of psoriasis., PMID:39832444
Structural insights into human topoisomerase 3β DNA and RNA catalysis and nucleic acid gate dynamics., PMID:39828754
Topoisomerase 3α (TOP3A) Dependent Alternative Lengthening of Telomeres (ALT)., PMID:39803571
Ritonavir enhances the efficacy of amprenavir: A promising combination therapy by targeting Leishmania DNA topoisomerase I for treatment of visceral leishmaniasis., PMID:39800043
Phosphine Oxide Indenoquinoline Derivatives: Synthesis and Biological Evaluation as Topoisomerase I Inhibitors and Antiproliferative Agents., PMID:39770084
Oleanolic Acid Modulates DNA Damage Response to Camptothecin Increasing Cancer Cell Death., PMID:39769237
TOP1 Mutations and Cross-Resistance to Antibody-Drug Conjugates in Patients with Metastatic Breast Cancer., PMID:39745368
Evaluating the role of active TGF-β1 as inflammatory biomarker in Kashmiri (North-Indian) patients with systemic sclerosis: a case-control study., PMID:39716300
Design, synthesis and anticancer evaluation of 4-Substituted 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidines as dual topoisomerase I and II inhibitors., PMID:39705937
TDP1 represents a promising therapeutic target for overcoming tumor resistance to chemotherapeutic agents: progress and potential., PMID:39705934
MRE11-independent effects of Mirin on mitochondrial DNA integrity and cellular immune responses., PMID:39705374
PNKP safeguards stalled replication forks from nuclease-dependent degradation during replication stress., PMID:39671289
TDP1 splice-site mutation causes HAP1 cell hypersensitivity to topoisomerase I inhibition., PMID:39660638
Structure-activity relationship study of novel evodiamine amino acid conjugates with potent anti-colorectal cancer efficacy., PMID:39647421
Design, synthesis and investigation of biological activity and mechanism of fluoroaryl-substituted derivatives at the FL118 position 7., PMID:39647420
Autophagy as a way to remove DNA lesions., PMID:39635883
Unveiling the Anticancer Potential of a New Ciprofloxacin-Chalcone Hybrid as an Inhibitor of Topoisomerases I & II and Apoptotic Inducer., PMID:39598770
Small Molecule Inhibitors of Mycobacterium tuberculosis Topoisomerase I Identified by Machine Learning and In Vitro Assays., PMID:39596331
Therapeutic co-assemblies for synergistic NSCLC treatment through dual topoisomerase I and tubulin inhibitors., PMID:39592024
TEX264-mediated selective autophagy directs DNA damage repair., PMID:39550277
Synergy trap for guardian angels of DNA: Unraveling the anticancer potential of phthalazinone-thiosemicarbazone hybrids through dual PARP-1 and TOPO-I inhibition., PMID:39488147
Excessive MYC-topoisome activity triggers acute DNA damage, MYC degradation, and replacement by a p53-topoisome., PMID:39481385
For research use only. Not for human or drug use.
