Catalog No.
YHG53601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser505-Arg745
Predicted molecular weight
28.05 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13444
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Disintegrin and metalloproteinase domain-containing protein 15, Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15, ADAM15, MDC15, Metalloprotease RGD disintegrin protein, Metargidin, MDC-15, ADAM 15
ADAMs contribute to triple negative breast cancer via mTORC1 pathway: targeting ADAM-mTOR axis improves efficacy., PMID:40339955
Multiple-omics analysis of aggrephagy-related cellular patterns and development of an aggrephagy-related signature for hepatocellular carcinoma., PMID:40307857
Mechanical forces trigger invasive behavior in synovial fibroblasts through N-cadherin/ADAM15 -dependent modulation of LncRNA H19., PMID:40118917
Profiling the Secretome of Glioblastoma Cells Under Histone Deacetylase Inhibition Using Mass Spectrometry., PMID:39959291
Proteome-wide mendelian randomization identifies causal plasma proteins in interstitial lung disease., PMID:39824903
TFDP1 overexpression promotes apoptosis of nucleus pulposus cells in intervertebral disc degeneration through regulating ADAM15/MMP9 axis., PMID:39815900
VE-cadherin may suppress inflammation depending on the phase of inflammation of rheumatoid arthritis., PMID:39656893
Unraveling the role of ADAMs in clinical heterogeneity and the immune microenvironment of hepatocellular carcinoma: insights from single-cell, spatial transcriptomics, and bulk RNA sequencing., PMID:39346916
Association of ADAM family members with proliferation signaling and disease progression in multiple myeloma., PMID:39261477
Characterization of circulating tumor cells in patients with metastatic bladder cancer utilizing functionalized microfluidics., PMID:39173508
Single-cell transcriptomic atlas of taste papilla aging., PMID:39169434
ADAM15 in Fibroblasts: Improving the Matrix Remodeling by Blocking the Action of Transforming Growth Factor-β1., PMID:39048163
Promoter hypermethylation-induced downregulation of ITGA7 promotes colorectal cancer proliferation and migration by activating the PI3K/AKT/NF-κB pathway., PMID:38885843
Genetic-informed proteome-wide scan reveals potential causal plasma proteins for idiopathic pulmonary fibrosis., PMID:38871465
Single-cell analysis defines LGALS1+ fibroblasts that promote proliferation and migration of intrahepatic cholangiocarcinoma., PMID:38862197
Identification of a novel matrix metalloproteinases-related prognostic signature in hepatocellular carcinoma., PMID:38761174
Loss of ADAM15 in female mice does not worsen pressure overload cardiomyopathy, independent of ovarian hormones., PMID:38607341
Digital spatial profiling of segmental outflow regions in trabecular meshwork reveals a role for ADAM15., PMID:38394161
Epigenetic Mechanisms Histone Deacetylase-Dependent Regulate the Glioblastoma Angiogenic Matrisome and Disrupt Endothelial Cell Behavior In Vitro., PMID:38272115
Whole-exome sequencing analysis of patent ductus arteriosus in a Japanese macaque (Macaca fuscata)., PMID:37990472
Gender-specific lncRNA-miRNA-mRNA regulatory network to reveal potential genes for primary open-angle glaucoma., PMID:37774963
Loss of cancer cell-derived ADAM15 alters the tumor microenvironment in colorectal tumors., PMID:37602921
Shared Genetics and Comorbid Genes of Amyotrophic Lateral Sclerosis and Parkinson's Disease., PMID:37534731
Comparative proteomic analysis of three major extracellular vesicle classes secreted from human primary and metastatic colorectal cancer cells: Exosomes, microparticles, and shed midbody remnants., PMID:37507836
Combining WGCNA and machine learning to construct immune-related EMT patterns to predict HCC prognosis and immune microenvironment., PMID:37480570
Identification of membrane proteins regulated by ADAM15 by SUSPECS proteomics., PMID:37388246
Comprehensive bioinformatics and experimental analysis of SH3PXD2B reveals its carcinogenic effect in gastric carcinoma., PMID:37211344
The C-type lectin domain of CD62P (P-selectin) functions as an integrin ligand., PMID:37184585
Glioma Cells Expressing High Levels of ALDH5A1 Exhibit Enhanced Migration Transcriptional Signature in Patient Tumors., PMID:36976494
Deep next-generation proteomics and network analysis reveal systemic and tissue-specific patterns in Fabry disease., PMID:36863609
Consistent DNA Hypomethylations in Prostate Cancer., PMID:36613831
The genetic regulation of protein expression in cerebrospinal fluid., PMID:36504281
Profiling the male germline genome to unravel its reproductive potential., PMID:36379263
Loss of ADAM15 Exacerbates Transition to Decompensated Myocardial Hypertrophy and Dilation Through Activation of the Calcineurin Pathway., PMID:36330793
Genomic Predictors of Brisk Walking Are Associated with Elite Sprinter Status., PMID:36292594
Identifying Novel Genes and Variants in Immune and Coagulation Pathways Associated with Macular Degeneration., PMID:36275200
Prognostic Value of an Integrin-Based Signature in Hepatocellular Carcinoma and the Identification of Immunological Role of LIMS2., PMID:36212176
NSUN2-mediated mRNA m5C Modification Regulates the Progression of Hepatocellular Carcinoma., PMID:36183976
Detection of ADAM15 in urine from patients with bladder cancer., PMID:35810783
Quantitative Proteomics Reveals That ADAM15 Can Have Proteolytic-Independent Functions in the Steady State., PMID:35736286
The role of YAP1 target gene CTGF in the anoikis resistance of rheumatoid arthritis synovial fibroblasts., PMID:35713503
Proteomic and clinical biomarkers for acute mountain sickness in a longitudinal cohort., PMID:35668171
Integrin α3/α6 and αV are implicated in ADAM15-activated FAK and EGFR signalling pathway individually and promote non-small-cell lung cancer progression., PMID:35597804
ADAM15 is required for optimal collagen cross-linking and scar formation following myocardial infarction., PMID:34995785
Serum peptidome: diagnostic window into pathogenic processes following occupational exposure to carbon nanomaterials., PMID:34711247
A Novel Pro-Inflammatory Mechanosensing Pathway Orchestrated by the Disintegrin Metalloproteinase ADAM15 in Synovial Fibroblasts., PMID:34685689
A Unified Transcriptional, Pharmacogenomic, and Gene Dependency Approach to Decipher the Biology, Diagnostic Markers, and Therapeutic Targets Associated with Prostate Cancer Metastasis., PMID:34680307
ADAM15 correlates with prognosis, immune infiltration and apoptosis in hepatocellular carcinoma., PMID:34426560
Quantitative Proteomics Reveals Changes Induced by TIMP-3 on Cell Membrane Composition and Novel Metalloprotease Substrates., PMID:33673623
Interleukin 13 (IL-13)-regulated expression of the chondroprotective metalloproteinase ADAM15 is reduced in aging cartilage., PMID:33381768
For research use only. Not for human or drug use.
