Catalog No.
YHG50701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr725-Thr1074
Predicted molecular weight
42.04 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13393
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Choline phosphatase 1, PLD1, Phospholipase D1, PLD 1, Phosphatidylcholine-hydrolyzing phospholipase D1, hPLD1
Dual Role for Pld1 in Klebsiella pneumoniae Virulence: Transcriptomics and Proteomics Provide Insights into Direct and Indirect Effects., PMID:40396329
Metabolomics and proteomics analyses reveal the role of the glycerophospholipid metabolism pathway in unexplained recurrent spontaneous abortion., PMID:40321821
Recessive genetic contribution to congenital heart disease in 5,424 probands., PMID:40030011
Phosphatidic acid induces cytoskeletal rearrangements through the Src-FAK-RhoA/ROCK signaling pathway during decidualization., PMID:39928310
ABA as a downstream signal actively participates in phthalanilic acid mediated cold tolerance of common beans (Phaseolus vulgaris)., PMID:39899960
Innovative production of highly potent equine neutralizing antibody against Hemiscorpius lepturus scorpion venom using recombinant mPLD1 protein., PMID:39842515
GPLD1+ cancer stem cells contribute to chemotherapy resistance and tumour relapse in intestinal cancer., PMID:39743241
Segetalin B promotes bone formation in ovariectomized mice by activating PLD1/SIRT1 signaling to inhibit γ-secretase-mediated Notch1 overactivation., PMID:39736459
Pathogenic single nucleotide polymorphisms in RhoA gene: Insights into structural and functional impacts on RhoA-PLD1 interaction through molecular dynamics simulation., PMID:39698059
Phospholipase D2 downregulates interleukin-1β secretion from tumor-associated macrophages to suppress bladder cancer progression., PMID:39528232
Inhibition of phospholipase D1 reduces pancreatic carcinogenesis in mice partly through a FAK-dependent mechanism., PMID:39487573
PLD1 is a key player in cancer stemness and chemoresistance: Therapeutic targeting of cross-talk between the PI3K/Akt and Wnt/β-catenin pathways., PMID:38945955
A positive feedback loop between PLD1 and NF-κB signaling promotes tumorigenesis of nasopharyngeal carcinoma., PMID:38885836
Molecular Pathways and Animal Models of Ebstein's Anomaly., PMID:38884760
Compound Shouwu Jiangzhi Granule regulates triacylglyceride synthesis to alleviate hepatic lipid accumulation., PMID:38744232
Mapping the global interactome of the ARF family reveals spatial organization in cellular signaling pathways., PMID:38606629
The high FKBP1A expression in WBCs as a potential screening biomarker for pancreatic cancer., PMID:38570626
PLD1 promotes spindle assembly and migration through regulating autophagy in mouse oocyte meiosis., PMID:38513669
Phospholipase D, a Novel Therapeutic Target Contributes to the Pathogenesis of Neurodegenerative and Neuroimmune Diseases., PMID:38487684
Lipopolysaccharide Stimulates A549 Cell Migration through p-Tyr 42 RhoA and Phospholipase D1 Activity., PMID:38275747
Study on the expression changes of lncRNA in patients with systemic lupus erythematosus and its correlation with Treg cells., PMID:38253780
Phospholipase D1 produces phosphatidic acid at sites of secretory vesicle docking and fusion., PMID:38117597
Recapitulation of anti-aging phenotypes by global overexpression of PTEN in mice., PMID:38114855
Genome-wide identification, structural homology analysis, and evolutionary diversification of the phospholipase D gene family in the venom gland of three scorpion species., PMID:38049721
The role and regulation of phospholipase D in metabolic disorders., PMID:37845091
Molecular Characteristics of Everolimus-resistant Renal Cell Carcinoma Cells Generated by Continuous Exposure to Everolimus., PMID:37772579
A newly developed PLD1 inhibitor ameliorates rheumatoid arthritis by regulating pathogenic T and B cells and inhibiting osteoclast differentiation., PMID:37722567
OGD/R-induced ferroptosis and pyroptosis in retinal pigment epithelium cells: Role of PLD1 and PLD2 modulation., PMID:37691020
Association of cigarette smoking with risk of colorectal cancer subtypes classified by gut microbiota., PMID:37529669
Selection and Validation of Reference Genes in Virus-Infected Sweet Potato Plants., PMID:37510381
Raf/MEK/ERK Signaling Pathway Is Involved in the Inhibition of Glioma Cell Proliferation and Invasion in the Ketogenic Microenvironment., PMID:37498407
Importance of PLD2 in an IL-23 driven psoriasiform dermatitis model and potential link to human psoriasis., PMID:37455419
Functional Role of Phospholipase D in Bone Metabolism., PMID:37449345
Mutation in mitral valve prolapse susceptible gene DCHS1 causes familial mitral annular disjunction., PMID:37399314
Nuclear PLD1 combined with NPM1 induces gemcitabine resistance through tumorigenic IL7R in pancreatic adenocarcinoma., PMID:37381714
Predicting a Stable Dimeric Form of the PD1-PDL1 Complex: Implications for Understanding the PD1 Activation Mechanism., PMID:37343227
Transcriptome Profiling Analysis of Breast Cancer Cell MCF-7 Treated by Sesamol., PMID:37274057
Inhibition of phospholipase D1 ameliorates hepatocyte steatosis and non-alcoholic fatty liver disease., PMID:37138676
V-ATPase modulates exocytosis in neuroendocrine cells through the activation of the ARNO-Arf6-PLD pathway and the synthesis of phosphatidic acid., PMID:37091866
Detection of Novel Pathogenic Variants in Two Families with Recurrent Fetal Congenital Heart Defects., PMID:36923242
Mapping the global interactome of the ARF family reveals spatial organization in cellular signaling pathways., PMID:36909472
Phospholipase D1 Attenuation Therapeutics Promotes Resilience against Synaptotoxicity in 12-Month-Old 3xTg-AD Mouse Model of Progressive Neurodegeneration., PMID:36834781
Classic Phytochemical Antioxidant and Lipoxygenase Inhibitor, Nordihydroguaiaretic Acid, Activates Phospholipase D through Oxidant Signaling and Tyrosine Phosphorylation Leading to Cytotoxicity in Lung Vascular Endothelial Cells., PMID:36820994
BPDE, the Migration and Invasion of Human Trophoblast Cells, and Occurrence of Miscarriage in Humans: Roles of a Novel lncRNA-HZ09., PMID:36719213
Multi-omics profiling of PC-3 cells reveals bufadienolides-induced lipid metabolic remodeling by regulating long-chain lipids synthesis and hydrolysis., PMID:36645548
The Role of Bromodomain and Extraterminal (BET) Proteins in Controlling the Phagocytic Activity of Microglia In Vitro: Relevance to Alzheimer's Disease., PMID:36613460
Recapitulation of anti-aging phenotypes by global, but not by muscle-specific, deletion of PAPP-A in mice., PMID:36542300
A fusion protein comprising pneumococcal surface protein A and a pneumolysin derivate confers protection in a murine model of pneumococcal pneumonia., PMID:36477013
Disruption of RBMS3 suppresses PD-L1 and enhances antitumor immune activities and therapeutic effects of auranofin against triple-negative breast cancer., PMID:36414028
Exosome Secretion and Epithelial-Mesenchymal Transition in Ovarian Cancer Are Regulated by Phospholipase D., PMID:36362078
For research use only. Not for human or drug use.
