Catalog No.
YHG48601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu20-Lys108
Predicted molecular weight
12.43 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13324
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CRH-R-2, CRH2R, Corticotropin-releasing factor receptor 2, CRH-R2, CRHR2, CRF-R2, CRFR-2, CRF-R-2, CRF2R, Corticotropin-releasing hormone receptor 2
Predator odor stress produces sex- and subpopulation-specific increases in alcohol drinking, anxiety-like behavior, and lateral hypothalamic Crh expression., PMID:40374160
Urocortin2 measurement for heart failure assessment., PMID:40275076
Genetic inactivation of the CRF2 receptor eliminates morphine-induced sociability deficits in female mice., PMID:40274013
Osmoregulatory contributions of the corticotropin-releasing factor system in the intestine of Atlantic salmon., PMID:40123464
Mast cells and corticotropin-releasing hormone receptors in duodenal tissue of children with functional dyspepsia., PMID:40050228
Suppression of Luteinizing Hormone Secretion in Female Mice by a Urocortin 2-CRHR2 Signaling Pathway., PMID:40037626
Enhanced cerebellar climbing fiber-Purkinje cell synaptic transmission via corticotropin-releasing factor receptor 2 during the chronic phase of spinal cord injury mice., PMID:39976017
Spinal CRH facilitates the micturition reflex via the CRH2 receptor in rats with normal bladder and bladder outlet obstruction., PMID:39875474
Central corticotropin releasing hormone receptor 2 may participate in sex differential regulation of cold-evoked eating behavior., PMID:39733820
Targeting corticotropin-releasing hormone receptor type 1 (Crhr1) neurons: validating the specificity of a novel transgenic Crhr1-FlpO mouse., PMID:39692887
Region-specific neuroadaptations of CRF1 and CRF2 expression following heroin exposure in female rats., PMID:39626795
Single Intranasal Administration of Ucn3 Affects the Development of PTSD Symptoms in an Animal Model., PMID:39595978
The effects of corticotropin-releasing factor (CRF) and urocortins on the noradrenaline (NA) released from the locus coeruleus (LC)., PMID:39581268
Genetic variants associated with age-related episodic memory decline implicate distinct memory pathologies., PMID:39559945
Role of canonical and non-canonical cAMP sources in CRHR2α-dependent signaling., PMID:39356686
Sex-dependent effects of acute stress and alcohol exposure during adolescence on mRNA expression of brain signaling systems involved in reward and stress responses in young adult rats., PMID:39327618
Brainstem transcriptomic changes in male Wistar rats after acute stress, comparing the use of duplex specific nuclease (DSN)., PMID:39300279
Epigenetic molecular underpinnings of brain structural-functional connectivity decoupling in patients with major depressive disorder., PMID:39029702
The diverse role of corticotropin-releasing factor (CRF) and its CRF1 and CRF2 receptors under pathophysiological conditions: Insights into stress/anxiety, depression, and brain injury processes., PMID:38857667
Differential contributions of G protein- or arrestin subtype-mediated signalling underlie urocortin 3-induced somatostatin secretion in pancreatic δ cells., PMID:38613153
Paeoniflorin Alleviates Anxiety and Visceral Hypersensitivity via HPA Axis and BDNF/TrkB/PLCγ1 Pathway in Maternal Separation-induced IBS-like Rats., PMID:38494933
Influence of copper source and dietary inclusion level on growth performance of weaned pigs and expression of trace element related genes in the small intestine., PMID:38492538
Temperature- and genotype-dependent stress response and activation of the hypothalamus-pituitary-interrenal axis during temperature-induced sex reversal in pejerrey Odontesthes bonariensis, a species with genotypic and environmental sex determination., PMID:38008372
Basolateral amygdala corticotropin releasing factor receptor 2 interacts with nonmuscle myosin II to destabilize memory in males., PMID:37995804
Chronic kidney disease may evoke anxiety by altering CRH expression in the amygdala and tryptophan metabolism in rats., PMID:37989901
CRH-R2 signalling modulates feeding and circadian gene expression in hypothalamic mHypoA-2/30 neurons., PMID:37900150
Lidocaine ameliorates intestinal barrier dysfunction in irritable bowel syndrome by modulating corticotropin-releasing hormone receptor 2., PMID:37736684
Corticosterone effects on postnatal cerebellar development in mice., PMID:37704081
The exploration of neuroinflammatory mechanism by which CRHR2 deficiency induced anxiety disorder., PMID:37640149
The Role of Corticotropin-Releasing Factor (CRF) and CRF-Related Peptides in the Social Behavior of Rodents., PMID:37626714
Novel corticotropin-releasing hormone receptor genes (CRHR1 and CRHR2) linkage to and association with polycystic ovary syndrome., PMID:37543650
Electroacupuncture in the treatment of IBS in rats: investigation of the mechanisms of CRH+ neurons in the paraventricular nucleus., PMID:37435647
Chronic UCN2 treatment desensitizes CRHR2 and improves insulin sensitivity., PMID:37402735
The expression of corticotropin-releasing hormone family peptides in premalignant and malignant vulvar lesions., PMID:37382757
Sodium butyrate facilitates CRHR2 expression to alleviate HPA axis hyperactivity in autism-like rats induced by prenatal lipopolysaccharides through histone deacetylase inhibition., PMID:37358267
A new prognostic model for RHOV, ABCC2, and CYP4B1 to predict the prognosis and association with immune infiltration of lung adenocarcinoma., PMID:37197482
Hypothalamic Corticotropin-Releasing Hormone Contributes to Hypertension in Spontaneously Hypertensive Rats., PMID:37160364
Electroacupuncture intervention on stress-induced cardiac autonomic imbalance in rats involves corticotropin-releasing hormone system activity., PMID:37096785
Food-dependent Cushing's syndrome due to unilateral adrenocortical adenoma with cortisol secretion without ACTH elevation detected in peripheral blood by the CRH test: a case report., PMID:37062723
CpG Methylation Levels in HPA Axis Genes Predict Chronic Pain Outcomes Following Trauma Exposure., PMID:36906051
CRHR1 endocytosis: Spatiotemporal regulation of receptor signaling., PMID:36813360
High-Fat Diet Exacerbates Stress Responsivity in Juvenile Traumatic Brain Injury., PMID:36680746
Sleep-Disturbance-Induced Microglial Activation Involves CRH-Mediated Galectin 3 and Autophagy Dysregulation., PMID:36611953
Maternal probiotic intake attenuates ileal Crh receptor gene expression in maternally separated rat offspring., PMID:36477851
Correlation Between Sleep Electroencephalogram, Brain-Derived Neurotrophic Factor, AVPR1B Gene Polymorphism, and Suicidal Behavior in Patients with Depression., PMID:36367618
Identification of the Characteristic Genes and their Roles in Lung Adenocarcinoma Lymph Node Metastasis through Machine Learning Algorithm., PMID:36277017
Different oxytocin and corticotropin-releasing hormone system changes in bipolar disorder and major depressive disorder patients., PMID:36126617
Identification of 8-gene risk prediction signature associated with NOTCH1 in stomach adenocarcinoma based on bioinformatics analysis., PMID:36092350
The Double Insult of Neonatal Cystitis Plus Adult Somatic Inflammation Results in Corticotropin Releasing Factor Type II Receptor-Dependent Bladder Hypersensitivity in Female Rats., PMID:36089237
Comorbidity of Novel CRHR2 Gene Variants in Type 2 Diabetes and Depression., PMID:36077219
For research use only. Not for human or drug use.
