Catalog No.
YHG48101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Arg110
Predicted molecular weight
15.42 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13315
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
A-T mutated, Ataxia telangiectasia mutated, Serine-protein kinase ATM, ATM
Moderate-Low Risk Breast Cancer Gene Expression in a Romanian Population., PMID:40508121
RNA transcripts regulate G-quadruplex landscapes through G-loop formation., PMID:40504899
Hereditary breast cancer beyond BRCA: clinicopathological characteristics and long-term outcomes., PMID:40504267
Defective Repair of G1-Phase Double-Strand Breaks in WRNIP1/Ku70 Double Knockout Cells., PMID:40484680
Genome rearrangements induced by the stimulation of end-joining of DNA double strand breaks through multiple phosphorylation of MRE11 by the kinase PKB/AKT1., PMID:40479710
[Mechanistic study on low expression of Ace2 gene activated senescence-related signals and promoted the progression of silicotic fibrosis in mice]., PMID:40468507
AIM2-Driven Inflammation in Periodontitis: Mechanisms and Systemic Implications., PMID:40463858
The decameric repeat (DR) of PSGL-1 functions as a basic antiviral unit in restricting HIV-1 infectivity., PMID:40463129
Loss of CD98HC phosphorylation by ATM impairs antiporter trafficking and drives glutamate toxicity in Ataxia telangiectasia., PMID:40456742
Single-cell sequencing reveals shared clonal signatures in nonmalignant B and tumor cells in T-prolymphocytic leukemia., PMID:40453149
Associations between ATM c.7271T>G and cancer risk: analysis of Breast Cancer Association Consortium and UK Biobank data., PMID:40451289
Focal High-Grade Areas with a Tumor-in-Tumor Pattern: Another Feature of Pediatric DICER1-Associated Thyroid Carcinoma?, PMID:40448797
Nucleoporins cooperate with Polycomb silencers to promote transcriptional repression and repair at DNA double-strand breaks., PMID:40440073
Retraction: hsa_circ_0000006 induces tumorigenesis through miR-361-3p targeting immunoglobulin-like domains protein 1 (LRIG1) in osteosarcoma., PMID:40438511
Elevated nonhomologous end-joining by AATF enables efficient DNA damage repair and therapeutic resistance in glioblastoma., PMID:40436899
The Development of Al18F-NOTA-FAP-2286 as an FAP-Targeted PET Tracer and the Translational Application in the Diagnosis of Acquired Drug Resistance in Progressive Prostate Cancer., PMID:40430845
Skin Fibroblasts from Individuals Self-Diagnosed as Electrosensitive Reveal Two Distinct Subsets with Delayed Nucleoshuttling of the ATM Protein in Common., PMID:40429933
C1QBP Modulates DNA Damage Response and Radiosensitivity in Hepatocellular Carcinoma by Regulating NF-κB Activity., PMID:40429658
Purification and Characterization of Endogenous α-Amylase from Glutinous Rice Flour., PMID:40428461
Precision Targeting in Metastatic Prostate Cancer: Molecular Insights to Therapeutic Frontiers., PMID:40427518
Cancer Vulnerabilities Through Targeting the ATR/Chk1 and ATM/Chk2 Axes in the Context of DNA Damage., PMID:40422251
NOTCH1 inhibition enhances immunogenicity and sensitizes triple-negative breast cancer to immune checkpoint inhibitors., PMID:40420289
5'UTR gene regions in germline DNA sequencing panels: lessons from the analysis of breast and ovarian cancer patients of Tatar and Bashkir ethnic origin., PMID:40419811
Nonradiolabeled Radioresistant DNA Synthesis and S-Phase Checkpoint Analysis., PMID:40418471
Detection rates of multigene panel and exome testing in patients with previous negative BRCA1/2 results., PMID:40418377
CS-6-induced p62 accumulation exacerbates DNA damage in colorectal cancer., PMID:40417224
Machine learning Reveals ATM and CNOT6L as critical factors in Cataract pathogenesis., PMID:40412792
Primary cilium restricts TGF-β/SMAD signaling induced RIBEs in the co-culture model., PMID:40412783
Disruption of ATR Signaling by Epstein-Barr Virus Latent Membrane Protein 1 Sensitizes Nasopharyngeal Carcinoma Cells to Cisplatin., PMID:40407079
Identification of Hub Genes and Pathways Associated with Ageing in Diabetic Encephalopathy Based on Transcriptome Analysis., PMID:40397335
Acetyl alkannin, a Shikonin monomer, inhibits the ATM/DDR pathway by targeting ATM and sensitizes cisplatin in solid tumors., PMID:40389196
Effects of two typical organophosphate flame retardants on DNA damage of GT1-7 cells and relevant molecular mechanism., PMID:40389058
PRDX1 protects ATM from arsenite-induced proteotoxicity and maintains its stability during DNA damage signaling., PMID:40387816
Comprehensive Transcriptomic Analysis in Wild-type and ATM Knockout Lung Cancer Cells: Influence of Cisplatin on Oxidative Stress-Induced Senescence., PMID:40383470
ANP32E drives vulnerability to ATR inhibitors by inducing R-loops-dependent transcription replication conflicts in triple negative breast cancer., PMID:40382323
Identification of nonsense variants in the ATM gene mimicking SCID phenotype: a brief report., PMID:40379838
Sevoflurane exposure triggers ferroptosis of neuronal cells initiated by the activation of ATM/p53 in the neonatal mouse brain via JNK/p38 MAPK-mediated oxidative DNA damage., PMID:40378436
Nucleosomes represent a crucial target for the intra-S phase checkpoint in response to replication stress., PMID:40378213
Gal-1 promotes lung cancer cell survival by enhancing PARP1/H1.2 interaction to promote DNA repair upon DNA damage response., PMID:40365664
A PP2A-mtATR-tBid axis links DNA damage-induced CIP2A degradation to apoptotic dormancy and therapeutic resistance in PDAC., PMID:40354992
The cold immunological landscape of ATM-deficient cancers., PMID:40350205
SIRT5-mediated desuccinylation of the porcine deltacoronavirus M protein drives pexophagy to enhance viral proliferation., PMID:40344161
Comparative in vivo toxicology of ATR inhibitors ceralasertib, elimusertib, and berzosertib alone and in combination with ionizing radiation., PMID:40339611
Multiomics analysis unveils an inosine-sensitive DNA damage response in neurogenic bladder after spinal cord injury., PMID:40338665
Exploring the promoter regions of cancer predisposition genes in patients with triple-negative breast cancer reveals the presence of rare germline variants., PMID:40338220
Corrigendum: Inhibition of ATM or ATR in combination with hypo-fractionated radiotherapy leads to a different immunophenotype on transcript and protein level in HNSCC., PMID:40337061
MS CETSA deep functional proteomics uncovers DNA repair programs leading to gemcitabine resistance., PMID:40335468
Downregulation of EZH2 Promotes Renal Epithelial Cellular Senescence and Kidney Aging., PMID:40326780
ATM and p53 in aging and cancer: a double-edged sword in genomic integrity., PMID:40323544
WDR11-DT enhances radiosensitivity via promoting PARP1 degradation and homologous recombination deficiency., PMID:40320037
For research use only. Not for human or drug use.
