Catalog No.
YHG47901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys43-Leu354
Predicted molecular weight
37.66 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13309
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Cyclin-A/CDK2-associated protein p45, F-box/LRR-repeat protein 1, S-phase kinase-associated protein 2, SKP2, p45skp2, FBXL1, F-box protein Skp2
CNTD1 is crucial for crossover formation in female meiosis and for establishing the ovarian reserve., PMID:40488668
CircHIPK3's dual role in promoting angiogenesis and inhibiting apoptosis through FASN mRNA stabilization in gallbladder cancer., PMID:40466438
Molecular hybridization strategy - discovery of 2,3-diarylpyrazine derivatives as potent Skp2 inhibitors with improved anti-tumor activity and enhanced cisplatin sensitivity., PMID:40460720
Expression and purification of functional recombinant Cullin1-Rbx1/2 in E. coli., PMID:40447239
Curcumin induces apoptosis via downregulation of SKP2 and induction of GADD45A/CDKN1A expression through generation of ROS in cutaneous T-cell lymphoma cells., PMID:40409732
Inhibition of Dormant Lung Cancer Cell Reactivation by Punica Granatum Peel and Dioscorea Nipponica: Involving MYC, SKP2 and p27., PMID:40391177
Microtubule dynamics is a therapeutic vulnerability in VHL-deficient renal cell carcinoma., PMID:40384876
Cell cycle duration determines oncogenic transformation capacity., PMID:40307557
Glycosylation Weakens Skp1 Homodimerization in Toxoplasma gondii by Interrupting a Fuzzy Interaction., PMID:40296701
KRIBB11 Exerts Anticancer Effects on A172 Glioblastoma Cells via the Cdh1/SKP2/p27 and HSF1/p53/p21 Pathways., PMID:40280718
Novel Skp1 inhibitor has potent preclinical efficacy against castration-resistant prostate cancer., PMID:40253488
Plasma Lipidomics and Proteomics Analyses Pre- and Post-5000 m Race in Yili Horses., PMID:40218387
E3 ligase Skp2-mediated stabilization of survivin contributes to radioresistance., PMID:40195315
The Hippo pathway and p27Kip1 cooperate to suppress mitotic regeneration in the organ of Corti and the retina., PMID:40178894
The role of insulin receptor InR in photoperiod-regulated reproductive diapause of Chrysoperla nipponensis., PMID:40158640
S-phase kinase-associated protein 1 inhibits orbital fibroblasts adipogenesis to improve thyroid-associated ophthalmopathy (TAO)., PMID:40139511
The F box protein INHIBITOR FOR BROWN FURROWS 1 (IBF1) regulates flavonoid accumulation in rice hull by promoting degradation of chalcone synthase 1., PMID:40121665
CUL1-neddylation contributes to K29-linked ubiquitination on p27 for autophagic degradation in sorafenib-resistant liver cancer., PMID:40111576
PDCD11 Stabilizes C-MYC Oncoprotein by Hindering C-MYC-SKP2 Negative Feedback Loop to Facilitate Progression of p53-Mutant Breast and Colon Malignancies., PMID:40051297
Gastrodin promotes ferroptosis in CRC cells by inhibiting SKP2 to reduce NCOA4 ubiquitination., PMID:40048831
A mitochondrial outer membrane protein TOMM20 maintains protein stability of androgen receptor and regulates AR transcriptional activity in prostate cancer cells., PMID:40044984
ARv7 promotes the escape of prostate cancer cells from androgen deprivation therapy-induced senescence by mediating the SKP2/p27 axis., PMID:40022149
Anticancer and Antioxidant Effects of Bioactive Peptides from Black Soldier Fly Larvae (Hermetia illucens)., PMID:40004973
Distinct outcomes from targeted perturbations of the multi-subunit SCFSkp2 E3 ubiquitin ligase in blocking Trp53/Rb1-null prostate tumorigenesis., PMID:39987265
Plant viruses convergently target NPR1 with various strategies to suppress salicylic acid-mediated antiviral immunity., PMID:39981868
Mechanism of histone demethylase KDM5A in osteoporotic fracture healing through epigenetic regulation of the miR-495/SKP2/Runx2 axis., PMID:39972431
Hypoxia-induced S-phase kinase-interacting protein 2 knockdown repressed the progression of melanoma through extracellular signal-regulated kinase 1/2 pathway., PMID:39958883
Modulation of almonertinib resistance in non-small cell lung cancer by cancer-associated fibroblasts through HK2-mediated glycolysis and SKP2 signaling., PMID:39954036
RNF6 promotes cell proliferation of glioblastoma by targeting ubiquitin-mediated degradation of p27., PMID:39938447
Structural Insight Into the SKP1-CUL1-FBXO3-RBX1 Complex., PMID:39921442
SKP1-CUL1-F-box: Key molecular targets affecting disease progression., PMID:39812503
Bacteroides Fragilis Transplantation Reverses Reproductive Senescence by Transporting Extracellular Vesicles Through the Gut-Ovary Axis., PMID:39805029
Genome-Wide Identification and Functional Characterization of SKP1-like Gene Family Reveal Its Involvement in Response to Stress in Cotton., PMID:39796275
Mitochondrial uncouplers inhibit oncogenic E2F1 activity and prostate cancer growth., PMID:39793570
Raddeanin A (RA) Inhibited EMT and Stemness in Glioblastoma via downregulating Skp2., PMID:39744562
Centipeda minima extracts and the active sesquiterpene lactones have therapeutic efficacy in non-small cell lung cancer by suppressing Skp2/p27 signaling pathway., PMID:39722328
LKB1 dictates sensitivity to immunotherapy through Skp2-mediated ubiquitination of PD-L1 protein in non-small cell lung cancer., PMID:39694700
Energy restriction inhibits β-catenin ubiquitination to improve ischemic stroke injury via USP18/SKP2 axis., PMID:39692824
Castration-resistant prostate cancer is resensitized to androgen deprivation by autophagy-dependent apoptosis induced by blocking SKP2., PMID:39689183
Knockout of onecut2 inhibits proliferation and promotes apoptosis of tumor cells through SKP2-mediated p53 acetylation in hepatocellular carcinoma., PMID:39609269
SKP2 inhibition activates tumor cell-intrinsic immunity by inducing DNA replication stress and genomic instability., PMID:39582087
Hypoxic and Acidic Tumor Microenvironment-Driven AVL9 Promotes Chemoresistance of Pancreatic Ductal Adenocarcinoma via the AVL9-IκBα-SKP1 Complex., PMID:39566663
Ginkgo biloba extract alleviates deltamethrin-induced testicular injury by upregulating SKP2 and inhibiting Beclin1-independent autophagy., PMID:39550920
Combined Treatment of Caffeic Acid Phenethyl Ester With Docetaxel Inhibits Survival of Non-small-cell Lung Cancer Cells via Suppression of c-MYC., PMID:39477300
IFI27 inhibits HIV-1 replication by degrading Gag protein through the ubiquitin-proteasome pathway., PMID:39475279
A Bacterial Platform for Studying Ubiquitination Cascades Anchored by SCF-Type E3 Ubiquitin Ligases., PMID:39456142
MAT1A activation of glycolysis to promote NSCLC progression depends on stabilizing CCND1., PMID:39438468
Structure of the CUL1-RBX1-SKP1-FBXO4 SCF ubiquitin ligase complex., PMID:39406020
Upregulated SKP2 Empowers Epidermal Proliferation Through Downregulation of P27 Kip1., PMID:39343755
Single-cell RNA sequencing reveals the communications between tumor microenvironment components and tumor metastasis in osteosarcoma., PMID:39324133
For research use only. Not for human or drug use.
