Catalog No.
YHG47801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu853-Pro1070
Predicted molecular weight
26.87 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13308
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Protein-tyrosine kinase 7, Inactive tyrosine-protein kinase 7, CCK4, PTK7, Colon carcinoma kinase 4, Tyrosine-protein kinase-like 7, CCK-4, Pseudo tyrosine kinase receptor 7
FGF receptor modulates planar cell polarity in the neuroectoderm via Vangl2 tyrosine phosphorylation., PMID:40501945
Quantification of Wnt3a, Wnt5a and Wnt16 Binding to Multiple Frizzleds Under Physiological Conditions Using NanoBit/BRET., PMID:40497984
Preclinical Evaluation of PTK7-Targeted Radionuclide Therapy., PMID:40495114
High-Throughput Multiplexed Quantification of Molecules by Aptamer Sequencing (Apt-seq) in Single Cells., PMID:40488675
Phototriggered LYTAC: Photoactive Bispecific Aptamer Chimera Enhances Targeted Degradation of Membrane Protein through Regulating Cell Autophagy., PMID:40479736
Property Characterization of Leucine-Integrated Oligonucleotide., PMID:40415219
Click-constructed modular signal aptamer chimeras enable receptor-independent degradation of membrane proteins., PMID:40388621
The Rho GEF Trio functions in contact inhibition of locomotion of neural crest cells by interacting with Ptk7., PMID:40326503
Non-canonical Wnt signaling promotes epithelial fluidization in the repairing airway., PMID:40319020
Sortilin-Mediated Rapid, Precise and Sustained Degradation of Membrane Proteins via mRNA-Encoded Lysosome-Targeting Chimera., PMID:40305781
Enhanced "Off-On" Electrochemiluminescent Biosensor Based on a Multivalent Aptamer-Induced Spatial Confinement Strategy for Ultrasensitive Detection of Membrane Protein (PTK-7)., PMID:40274545
Multiplexed Detection of Tumor Markers and Discrimination of Cancer Cell Types by Laser Ablation-Dielectric Barrier Discharge Ionization-Mass Spectrometry., PMID:40262027
The R-RAS2 GTPase is a signaling hub in triple-negative breast cancer cell metabolism and metastatic behavior., PMID:40221767
Identification of the Staphylococcus aureus endothelial cell surface interactome by proximity labeling., PMID:40162795
A phase 1b study of cofetuzumab pelidotin monotherapy in patients with PTK7-expressing recurrent non-small cell lung cancer., PMID:40086026
An overview of Sgc8 aptamer as a potential theranostic agent for cancer with PTK7 oncogenic target., PMID:40033943
PTK7 helps detect T lymphoblastic leukemia/lymphoma by flow cytometry., PMID:40013536
Extracellular Vesicles Separation and Biomedical Application Based on Affinity Recognition and Antifouling Coating Bifunctional Microsphere., PMID:39977271
Anti-PTK7 Monoclonal Antibodies Suppresses Oncogenic Phenotypes in Cellular and Xenograft Models of Triple-Negative Breast Cancer., PMID:39936972
Aptamer-Guided, Hydrolysis-Resistant Deoxyoxanosine Enables Epitope- and Moiety-Selective Conjugation to Nonengineered Proteins Even in Complex Environments., PMID:39933564
Illuminating the Role of Wound Healing-Related Hub Genes in Colorectal Adenocarcinoma: Molecular Mechanisms, Prognostic Implications, and Therapeutic Potential., PMID:39757675
Aptamer sgc8-Modified PAMAM Nanoparticles for Targeted siRNA Delivery to Inhibit BCL11B in T-Cell Acute Lymphoblastic Leukemia., PMID:39583320
USP8-mediated PTK7 promotes PIK3CB-related pathway to accelerate the malignant progression of non-small cell lung cancer., PMID:39552193
PTK7: an underestimated contributor to human cancer., PMID:39474113
Therapeutic targeting of the protein tyrosine kinase-7 in cancer: an overview., PMID:39468753
Protein Tyrosine Kinase 7 (PTK7) in Breast Cancer: A Retrospective Analysis of Tumour Expression and Association with Clinical Outcome., PMID:39335176
RCC1 regulation of subcellular protein localization via Ran GTPase drives pancreatic ductal adenocarcinoma growth., PMID:39321913
A DNA Molecular Logic Circuit for Precise Tumor Identification., PMID:39315658
Cell Polarity-related Gene PTK7, a Potential Diagnostic Biomarker in Pan-cancer., PMID:39253927
Development of Integrin-Facilitated Bispecific Aptamer Chimeras for Membrane Protein Degradation., PMID:39226482
An Aptamer Glue Enables Hyperefficient Targeted Membrane Protein Degradation., PMID:39211579
Aptamer-Loop DNA Nanoflower Recognition and Multicolor Fluorescent Carbon Quantum Dots Labeling System for Multitarget Living Cell Imaging., PMID:39161311
Intraglandular dissemination: a special pathological feature., PMID:39135992
Robust aptamer-targeted CRISPR/Cas9 delivery using mesenchymal stem cell membrane -liposome hybrid: BIRC5 gene knockout against melanoma., PMID:39127174
Structure-based investigation of a DNA aptamer targeting PTK7 reveals an intricate 3D fold guiding functional optimization., PMID:38985770
Fluorescent identification of immunomagnetically captured CTCs using triplex-aptamer-targeted dendritic SiO2@Fe3O4 nanocomposite., PMID:38922365
Identification of the Binding Site between Aptamer sgc8c and PTK7., PMID:38889444
Recent insights into the therapeutic strategies targeting the pseudokinase PTK7 in cancer., PMID:38773263
FOXP4-mediated induction of PTK7 activates the Wnt/β-catenin pathway and promotes ovarian cancer development., PMID:38740744
Elucidating the Functional Mechanism of PTK7 in Cancer Development through Spatial Assembly Analysis Using Super Resolution Imaging., PMID:38708542
Polyfluoroalkyl Tag Decoration Enables Significantly Enhanced Tumor Penetration Ability of a PTK7 Targeting Aptamer., PMID:38695582
Single-cell SERS imaging of dual cell membrane receptors expression influenced by extracellular matrix stiffness., PMID:38678888
Kinome expression profiling improves risk stratification and therapeutic targeting in myelodysplastic syndromes., PMID:38527292
The Wnt Co-Receptor PTK7/Otk and Its Homolog Otk-2 in Neurogenesis and Patterning., PMID:38474329
Domain-Targeted Membrane Partitioning of Specific Proteins with DNA Nanodevices., PMID:38466380
Multiplex Profiling of Biomarker and Drug Uptake in Single Cells Using Microfluidic Flow Cytometry and Mass Spectrometry., PMID:38359901
CAR-Aptamers Enable Traceless Enrichment and Monitoring of CAR-Positive Cells and Overcome Tumor Immune Escape., PMID:38148412
Loss of MTA2-mediated downregulation of PTK7 inhibits hepatocellular carcinoma metastasis progression by modulating the FAK-MMP7 axis., PMID:38050825
Proteomic insights into the associations between obesity, lifestyle factors, and coronary artery disease., PMID:38049831
Unravelling transcriptomic complexity in breast cancer through modulation of DARPP-32 expression and signalling pathways., PMID:38036593
For research use only. Not for human or drug use.
