Catalog No.
YHG45601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys32-Ile179
Predicted molecular weight
19.47 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13241
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Killer cell lectin-like receptor subfamily D member 1, NK cell receptor, Natural killer cells antigen CD94, CD94, KP43, KLRD1
Complete CD16A Deficiency and Defective NK Cell Function in a Man Living with HIV., PMID:40411624
Human Cytomegalovirus Antigen Presentation by HLA-G in Infected Cells., PMID:40347012
Structural Basis of SARS-CoV-2 Nsp13-Derived Peptide-Mediated NK Cell Activation., PMID:40331402
HLA-E/peptide complexes differentially interact with NKG2A/CD94 and T cell receptors., PMID:40085431
CD94-driven in vitro expansion of highly functional adaptive NKG2C+ NKG2A- CD57+ NK cells from CMV+ healthy donors., PMID:39958331
HLA-E: Immune Receptor Functional Mechanisms Revealed by Structural Studies., PMID:39753525
Recognition of Self and Viral Ligands by NK Cell Receptors., PMID:39748148
Th17 and effector CD8 T cells relate to disease progression in amyotrophic lateral sclerosis: a case control study., PMID:39731185
All-Atom Simulations Reveal the Effect of Membrane Composition on the Signaling of the NKG2A/CD94/HLA-E Immune Receptor Complex., PMID:39621690
NKG2C Sequence Polymorphism Modulates the Expansion of Adaptive NK Cells in Response to Human CMV., PMID:39581700
Diagnosis of canine B-cell chronic lymphoid leukemia with a CD21 negative phenotype using the LT21 clone CD21 antibody in flow cytometry: a case report., PMID:39462364
CD94 deficiency or blockade unleashes the anti-tumor immunity in mice and humanized murine models., PMID:39424259
Interfering with KIR and NKG2A immune checkpoint axes to unleash NK cell immunotherapy., PMID:39396258
Peripheral NK cell phenotypic alteration and dysfunctional state post hepatitis B subviral particles stimulation in CHB patients: evading immune surveillance., PMID:39328404
A role of gut microbiota metabolites in HLA-E and NKG2 blockage immunotherapy against tumors: new insights for clinical application., PMID:39229258
CD94+ natural killer cells potentiate pulmonary ischaemia-reperfusion injury., PMID:39190789
Polygenic polymorphism is associated with NKG2A repertoire and influences lymphocyte phenotype and function., PMID:39158076
LAG-3 sustains TOX expression and regulates the CD94/NKG2-Qa-1b axis to govern exhausted CD8 T cell NK receptor expression and cytotoxicity., PMID:39121847
HLA-E-expressing macrophage polarization and increased NKG2A/CD94 expression in adult-onset Still's disease., PMID:38958876
Unraveling factors responsible for pathogenic differences in Lassa virus strains., PMID:38826374
Multifactorial determinants of NK cell repertoire organization: insights into age, sex, KIR genotype, HLA typing, and CMV influence., PMID:38736873
CD8+ T cell targeting of tumor antigens presented by HLA-E., PMID:38728394
Dual Checkpoint Aptamer Immunotherapy: Unveiling Tailored Cancer Treatment Targeting CTLA-4 and NKG2A., PMID:38473398
Comprehensive profiling of cell subsets of gastric cancer and liver metastasis based on single cell RNA-sequencing analysis., PMID:38410212
Phase 1/2 study of monalizumab plus durvalumab in patients with advanced solid tumors., PMID:38309722
Crosstalk Between NK Cell Receptors and Tumor Membrane Hsp70-Derived Peptide: A Combined Computational and Experimental Study., PMID:38298098
Characteristics of splenic PD-1+ γδT cells in Plasmodium yoelii nigeriensis infection., PMID:38265549
A Noncanonical CD56dimCD16dim/- NK Cell Subset Indicative of Prior Cytotoxic Activity Is Elevated in Patients with Autoantibody-Mediated Neurologic Diseases., PMID:38251887
Evaluation of the TLR3 involvement during Schistosoma japonicum-induced pathology., PMID:38172683
Structure of the murine CD94-NKG2A receptor in complex with Qa-1b presenting an MHC-I leader peptide., PMID:38158698
Biomarkers in Adult-Type Diffuse Gliomas: Elevated Levels of Circulating Vesicular Heat Shock Protein 70 Serve as a Biomarker in Grade 4 Glioblastoma and Increase NK Cell Frequencies in Grade 3 Glioma., PMID:38137456
Electrophile Scanning Reveals Reactivity Hotspots for the Design of Covalent Peptide Binders., PMID:38069818
Antigen-specific memory NK cell responses against HIV and influenza use the NKG2/HLA-E axis., PMID:38064568
The MHC-E peptide ligands for checkpoint CD94/NKG2A are governed by inflammatory signals, whereas LILRB1/2 receptors are peptide indifferent., PMID:38048225
Decreased CD56+CD16-CD94+uNK cells in the mid-luteal phase in women with recurrent implantation failure are associated with IL-15 deficiency., PMID:38009057
Analysis of Butyrophilin-Mediated Activation of γδ T Cells from Human Spleen., PMID:37991420
Increased IL-10-competent regulatory B cells in the decidua of early human pregnancy., PMID:37683533
Upregulated CD8+ MAIT cell differentiation and KLRD1 gene expression after inactivated SARS-CoV-2 vaccination identified by single-cell sequencing., PMID:37654490
High-throughput characterization of HLA-E-presented CD94/NKG2x ligands reveals peptides which modulate NK cell activation., PMID:37558657
HLA-E-restricted SARS-CoV-2-specific T cells from convalescent COVID-19 patients suppress virus replication despite HLA class Ia down-regulation., PMID:37390223
The NK cell checkpoint NKG2A maintains expansion capacity of human NK cells., PMID:37386090
Establishing NK-Cell Receptor Restriction by Flow Cytometry and Detecting Potential NK-Cell Clones of Uncertain Significance., PMID:37385341
HLA class I signal peptide polymorphism determines the level of CD94/NKG2-HLA-E-mediated regulation of effector cell responses., PMID:37264229
Integration analysis of tumor metagenome and peripheral immunity data of diffuse large-B cell lymphoma., PMID:37234150
All-Atom Simulations Reveal the Intricacies of Signal Transduction upon Binding of the HLA-E Ligand to the Transmembrane Inhibitory CD94/NKG2A Receptor., PMID:37207294
Cytokines induced memory-like NK cells engineered to express CD19 CAR exhibit enhanced responses against B cell malignancies., PMID:37207215
Activating NKG2C Receptor: Functional Characteristics and Current Strategies in Clinical Applications., PMID:36899273
Population Pharmacokinetics of Monalizumab in Patients With Advanced Solid Tumors., PMID:36852723
Immune checkpoint HLA-E:CD94-NKG2A mediates evasion of circulating tumor cells from NK cell surveillance., PMID:36706761
Single-cell RNA sequencing identifies a population of human liver-type ILC1s., PMID:36640314
For research use only. Not for human or drug use.
