Catalog No.
YHG45301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ile1307-Arg1509
Predicted molecular weight
24.58 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13233
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
MAPK/ERK kinase kinase 1, Mitogen-activated protein kinase kinase kinase 1, MAP3K1, MEKK 1, MEKK, MEK kinase 1, MAPKKK1, MEKK1
A novel variant in the MAP3K1 genomic locus reveals abnormal cell apoptosis as a potential pathogenic mechanism in 46, XY disorders of sex development., PMID:40476564
Fgf21 Deficiency Delays Hair Follicle Cycling and Modulates miRNA-Target Gene Interactions in Mice., PMID:40427715
Identification of the hub genes involved in ATF5 mediated stress response in vitrified mouse oocytes based on WGCNA., PMID:40409046
A Selective MAP3K1 Inhibitor Facilitates Discovery of NPM1 as a Member of the Network., PMID:40363807
Proteomic Profiling of Hu Sheep Placental Development Across Gestational Stages Reveals Stage-Specific Regulatory Networks., PMID:40362472
Association of Androgen Receptor Expression With Tumor Immune Landscape and Treatment Outcomes of Patients With Breast Cancer., PMID:40294352
Genetic variants and molecular profiling of 46,XY gonadal dysgenesis using whole-exome sequencing., PMID:40290305
Oleanolic Acid@SPIONs Alleviates Lipid-Oxidative Stress Injury of Zebrafish Blood Vessels via Regulating the Expression of JNK and MAPK Signaling Pathways in Vascular Endothelial Cells., PMID:40255470
Comprehensive germline and somatic profiling of high-risk Thai breast cancer via next-generation sequencing., PMID:40181060
map3k1 suppresses terminal differentiation of migratory eye progenitors in planarian regeneration., PMID:40096024
Macrophage-targeting nano-formulated bicalutamide alleviates colitis by inducing MAP3K1-mediated degradation of NLRP3., PMID:39892647
Genomic Characterization and Prognostic Significance of Human Epidermal Growth Factor Receptor 2-Low, Hormone Receptor-Positive, Early Breast Cancers From the BIG 1-98 and SOFT Clinical Trials., PMID:39854658
KMT2C Polymorphism in Familial Hypospadias., PMID:39812948
Ipsilateral Breast Carcinoma Recurrence: True Recurrence or New Primary? A Clinicopathologic and Molecular Study., PMID:39780328
Novel kinase regulators of extracellular matrix internalisation identified by high-content screening modulate invasive carcinoma cell migration., PMID:39666682
MAP3K1 mutations confer tumor immune heterogeneity in hormone receptor-positive HER2-negative breast cancer., PMID:39531335
Breast cancer genomic analyses reveal genes, mutations, and signaling networks., PMID:39496981
Mitogen-activated protein kinase kinase kinase 1 facilitates the temozolomide resistance and migration of GBM via the MEK/ERK signalling., PMID:39443331
Germline DNA Damage Repair Gene Alterations in Patients with Metachronous Breast and Colorectal Cancer., PMID:39408606
Solitary Renal Metastases From Stage IA Primary Lung Adenocarcinoma With Co-Alteration of EGFR, RB1, and MAP3K1: A Case Report., PMID:39384216
VEGF-dependent testicular vascularisation involves MEK1/2 signalling and the essential angiogenesis factors, SOX7 and SOX17., PMID:39354506
A disease-associated PPP2R3C-MAP3K1 phospho-regulatory module controls centrosome function., PMID:39317195
Prognostic Value of IGFBP6 in Breast Cancer: Focus on Glucometabolism., PMID:39275851
Genome-wide methylation analysis in patients with proximal hypospadias - a pilot study and review of the literature., PMID:39151125
In-depth transcriptome profiling of Cherry Valley duck lungs exposed to chronic heat stress., PMID:39104549
Deafness DFNB128 Associated with a Recessive Variant of Human MAP3K1 Recapitulates Hearing Loss of Map3k1-Deficient Mice., PMID:39062623
Comprehensive analysis of MAPK genes in the prognosis, immune characteristics, and drug treatment of renal clear cell carcinoma using bioinformatic analysis and Mendelian randomization., PMID:39038636
Crosstalk of MAP3K1 and EGFR signaling mediates gene-environment interactions that block developmental tissue closure., PMID:38897570
Comprehensive genomic profiling and therapeutic implications for Taiwanese patients with treatment-naïve breast cancer., PMID:38895905
MiRNA let-7d-5p Alleviates Inflammatory Responses by Targeting Map3k1 and Inactivating ERK/p38 MAPK Signaling in Microglia., PMID:38848290
A disease-associated PPP2R3C-MAP3K1 phospho-regulatory module controls centrosome function., PMID:38617270
MAP3K1 regulates female reproductive tract development., PMID:38501211
RelA and mitogen-activated protein kinase kinase kinases potently enhance lentiviral vector production., PMID:38328371
Genomic Characteristics and Its Therapeutic Implications in Breast Cancer Patients with Detectable Molecular Residual Disease., PMID:38062709
Association of Germline Variation in Driver Genes with Breast Cancer Risk in Chilean Population., PMID:38003265
Circulating miR-320b Contributes to CD4+ T-Cell Proliferation in Systemic Lupus Erythematosus via MAP3K1., PMID:37928434
MiR-1a-3p Inhibits Apoptosis in Fluoride-exposed LS8 Cells by Targeting Map3k1., PMID:37782397
Literature-Based Discovery to Elucidate the Biological Links between Resistant Hypertension and COVID-19., PMID:37759668
Exome sequencing identifies breast cancer susceptibility genes and defines the contribution of coding variants to breast cancer risk., PMID:37592023
miR-21 Targets ASPP2 to Inhibit Apoptosis via CHOP-Mediated Signaling in Helicobacter pylori-Infected Gastric Cancer Cells., PMID:37547633
Genetic and Immunohistochemical Profiling of Mammary Hidradenoma and Comparison to Mucoepidermoid Carcinoma., PMID:37422157
Whole exome sequencing identifies MAP3K1, MSH2, and MLH1 as potential cancer-predisposing genes in familial early-onset colorectal cancer., PMID:37314251
A homozygous missense mutation in the fibroblast growth factor 5 gene is associated with the long-hair trait in Angora rabbits., PMID:37268908
MAP3K1 expression is associated with progression and poor prognosis of hormone receptor-positive, HER2-negative early-stage breast cancer., PMID:37166744
The Role of MAP3K1 in the Development of the Female Reproductive Tract., PMID:37131749
Insights into the regulation of MAP3K1 in hair follicle stem cells by transcriptome analysis., PMID:37014133
Lack of Association of Polymorphism Located Upstream of ABCA1 (rs2472493), in FNDC3B (rs7636836), and Near ANKRD55-MAP3K1 Genes (rs61275591) in Primary Open-Angle Glaucoma Patients of Saudi Origin., PMID:36980976
Clinical Next-Generation Sequencing Panels Reveal Molecular Differences Between Merkel Cell Polyomavirus-Negative Merkel Cell Carcinomas and Neuroendocrine Carcinomas., PMID:36812363
Early Triple-Negative Breast Cancers in a Singapore Cohort Exhibit High PIK3CA Mutation Rates Associated With Low PD-L1 Expression., PMID:36788078
Novel Molecular Therapies and Genetic Landscape in Selected Rare Diseases with Hematologic Manifestations: A Review of the Literature., PMID:36766791
For research use only. Not for human or drug use.
