Catalog No.
YHG45301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ile1307-Arg1509
Predicted molecular weight
24.58 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13233
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
MAPK/ERK kinase kinase 1, Mitogen-activated protein kinase kinase kinase 1, MAP3K1, MEKK 1, MEKK, MEK kinase 1, MAPKKK1, MEKK1
Note
For research use only.
Novel Molecular Therapies and Genetic Landscape in Selected Rare Diseases with Hematologic Manifestations: A Review of the Literature., PMID:36766791
Early Triple-Negative Breast Cancers in a Singapore Cohort Exhibit High PIK3CA Mutation Rates Associated With Low PD-L1 Expression., PMID:36788078
Clinical Next-Generation Sequencing Panels Reveal Molecular Differences Between Merkel Cell Polyomavirus-Negative Merkel Cell Carcinomas and Neuroendocrine Carcinomas., PMID:36812363
Lack of Association of Polymorphism Located Upstream of ABCA1 (rs2472493), in FNDC3B (rs7636836), and Near ANKRD55-MAP3K1 Genes (rs61275591) in Primary Open-Angle Glaucoma Patients of Saudi Origin., PMID:36980976
Insights into the regulation of MAP3K1 in hair follicle stem cells by transcriptome analysis., PMID:37014133
The Role of MAP3K1 in the Development of the Female Reproductive Tract., PMID:37131749
MAP3K1 expression is associated with progression and poor prognosis of hormone receptor-positive, HER2-negative early-stage breast cancer., PMID:37166744
A homozygous missense mutation in the fibroblast growth factor 5 gene is associated with the long-hair trait in Angora rabbits., PMID:37268908
Whole exome sequencing identifies MAP3K1, MSH2, and MLH1 as potential cancer-predisposing genes in familial early-onset colorectal cancer., PMID:37314251
Genetic and Immunohistochemical Profiling of Mammary Hidradenoma and Comparison to Mucoepidermoid Carcinoma., PMID:37422157
miR-21 Targets ASPP2 to Inhibit Apoptosis via CHOP-Mediated Signaling in Helicobacter pylori-Infected Gastric Cancer Cells., PMID:37547633
Exome sequencing identifies breast cancer susceptibility genes and defines the contribution of coding variants to breast cancer risk., PMID:37592023
Literature-Based Discovery to Elucidate the Biological Links between Resistant Hypertension and COVID-19., PMID:37759668
MiR-1a-3p Inhibits Apoptosis in Fluoride-exposed LS8 Cells by Targeting Map3k1., PMID:37782397
Circulating miR-320b Contributes to CD4+ T-Cell Proliferation in Systemic Lupus Erythematosus via MAP3K1., PMID:37928434
Association of Germline Variation in Driver Genes with Breast Cancer Risk in Chilean Population., PMID:38003265
Genomic Characteristics and Its Therapeutic Implications in Breast Cancer Patients with Detectable Molecular Residual Disease., PMID:38062709
RelA and mitogen-activated protein kinase kinase kinases potently enhance lentiviral vector production., PMID:38328371
MAP3K1 regulates female reproductive tract development., PMID:38501211
A disease-associated PPP2R3C-MAP3K1 phospho-regulatory module controls centrosome function., PMID:38617270
MiRNA let-7d-5p Alleviates Inflammatory Responses by Targeting Map3k1 and Inactivating ERK/p38 MAPK Signaling in Microglia., PMID:38848290
Comprehensive genomic profiling and therapeutic implications for Taiwanese patients with treatment-naïve breast cancer., PMID:38895905
Crosstalk of MAP3K1 and EGFR signaling mediates gene-environment interactions that block developmental tissue closure., PMID:38897570
Comprehensive analysis of MAPK genes in the prognosis, immune characteristics, and drug treatment of renal clear cell carcinoma using bioinformatic analysis and Mendelian randomization., PMID:39038636
Deafness DFNB128 Associated with a Recessive Variant of Human MAP3K1 Recapitulates Hearing Loss of Map3k1-Deficient Mice., PMID:39062623
In-depth transcriptome profiling of Cherry Valley duck lungs exposed to chronic heat stress., PMID:39104549
Genome-wide methylation analysis in patients with proximal hypospadias - a pilot study and review of the literature., PMID:39151125
Prognostic Value of IGFBP6 in Breast Cancer: Focus on Glucometabolism., PMID:39275851
A disease-associated PPP2R3C-MAP3K1 phospho-regulatory module controls centrosome function., PMID:39317195
VEGF-dependent testicular vascularisation involves MEK1/2 signalling and the essential angiogenesis factors, SOX7 and SOX17., PMID:39354506
Solitary Renal Metastases From Stage IA Primary Lung Adenocarcinoma With Co-Alteration of EGFR, RB1, and MAP3K1: A Case Report., PMID:39384216
Germline DNA Damage Repair Gene Alterations in Patients with Metachronous Breast and Colorectal Cancer., PMID:39408606
Mitogen-activated protein kinase kinase kinase 1 facilitates the temozolomide resistance and migration of GBM via the MEK/ERK signalling., PMID:39443331
Breast cancer genomic analyses reveal genes, mutations, and signaling networks., PMID:39496981
MAP3K1 mutations confer tumor immune heterogeneity in hormone receptor-positive HER2-negative breast cancer., PMID:39531335
Novel kinase regulators of extracellular matrix internalisation identified by high-content screening modulate invasive carcinoma cell migration., PMID:39666682
Ipsilateral Breast Carcinoma Recurrence: True Recurrence or New Primary? A Clinicopathologic and Molecular Study., PMID:39780328
KMT2C Polymorphism in Familial Hypospadias., PMID:39812948
Genomic Characterization and Prognostic Significance of Human Epidermal Growth Factor Receptor 2-Low, Hormone Receptor-Positive, Early Breast Cancers From the BIG 1-98 and SOFT Clinical Trials., PMID:39854658
Macrophage-targeting nano-formulated bicalutamide alleviates colitis by inducing MAP3K1-mediated degradation of NLRP3., PMID:39892647
map3k1 suppresses terminal differentiation of migratory eye progenitors in planarian regeneration., PMID:40096024
Comprehensive germline and somatic profiling of high-risk Thai breast cancer via next-generation sequencing., PMID:40181060
Oleanolic Acid@SPIONs Alleviates Lipid-Oxidative Stress Injury of Zebrafish Blood Vessels via Regulating the Expression of JNK and MAPK Signaling Pathways in Vascular Endothelial Cells., PMID:40255470
Genetic variants and molecular profiling of 46,XY gonadal dysgenesis using whole-exome sequencing., PMID:40290305
Association of Androgen Receptor Expression With Tumor Immune Landscape and Treatment Outcomes of Patients With Breast Cancer., PMID:40294352
Proteomic Profiling of Hu Sheep Placental Development Across Gestational Stages Reveals Stage-Specific Regulatory Networks., PMID:40362472
A Selective MAP3K1 Inhibitor Facilitates Discovery of NPM1 as a Member of the Network., PMID:40363807
Identification of the hub genes involved in ATF5 mediated stress response in vitrified mouse oocytes based on WGCNA., PMID:40409046
Fgf21 Deficiency Delays Hair Follicle Cycling and Modulates miRNA-Target Gene Interactions in Mice., PMID:40427715
A novel variant in the MAP3K1 genomic locus reveals abnormal cell apoptosis as a potential pathogenic mechanism in 46, XY disorders of sex development., PMID:40476564
For research use only. Not for human or drug use.
