Catalog No.
YHG44701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu317-Pro532
Predicted molecular weight
26.94 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13219
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PAPPA, PAPP-A, Pappalysin-1, IGF-dependent IGFBP-4 protease, Pregnancy-associated plasma protein A, Insulin-like growth factor-dependent IGF-binding protein 4 protease, IGFBP-4ase
Prospective Evaluation of Screening Performance of First-Trimester Prediction Models for Preterm Preeclampsia., PMID:40511070
Artificial Intelligence Applications in Obstetric Risk Prediction: A Systematic Review of Machine Learning Models for Preeclampsia., PMID:40510095
Cardiovascular health in early pregnancy and circulating placental biomarkers., PMID:40475135
Prognostic Impact of Pregnancy-Associated Plasma Protein-A (PAPP-A) for Gestational Diabetes Mellitus (GDM): An Updated Systematic Review and Meta-Analysis of More Than 90 000 Pregnancies., PMID:40474757
Plasma proteome profiling of massive perivillous fibrin deposition (MPFD) in women with recurrent Miscarriages: Pathophysiological insights and biomarker discovery., PMID:40472641
Study of first-trimester serum levels of β-hCG and PAPP-A as a screening test for fetal development of intrauterine growth restriction., PMID:40468231
Determining the risk of gestational diabetes using machine learning: A study on first-trimester PAPP-A and β-hCG data., PMID:40454615
Evaluating the Chemical Composition and Antitumor Activity of Origanum vulgare ssp. hirtum Essential Oil in a Preclinical Colon Cancer Model., PMID:40429884
Correlation between first trimester placental growth factor levels and skin microvascular reactivity assessed by laser speckle contrast imaging - a cross-sectional study., PMID:40413909
Assessment of a salivary cfRNA biomarker panel to predict preeclampsia., PMID:40393217
Combined assessment of placental growth factor, uterine artery pulsation index, and mean arterial pressure for predicting preeclampsia., PMID:40385044
Unraveling Venetoclax Resistance: Navigating the Future of HMA/Venetoclax-Refractory AML in the Molecular Era., PMID:40361510
New first trimester circulating angiogenic biomarkers in predicting early-onset and late-onset fetal growth restriction: a case-control study., PMID:40349027
A systematic review of emerging RNA markers in thyroid fine needle aspiration cytology samples: advancements and challenges., PMID:40346322
The exercise-conditioned human serum and skeletal muscle cells secretome induce apoptosis in breast cancer cells., PMID:40334838
CircPAPPA binds to PAPPA and promotes trophoblast proliferation in spontaneous abortion through the formation of circPAPPA-PAPPA complexes., PMID:40318815
Maternal first trimester SIMPLE nutritional score, early markers of placental function and pregnancy outcome: a prospective multicenter Italian study (SIMPLE study)., PMID:40307596
First-Trimester Preeclampsia Screening During the COVID-19 Pandemic: A Quality Improvement Comparison of the National Institute for Health and Care Excellence (NICE) Guidelines vs. Simplified Fetal Medicine Foundation Algorithm., PMID:40291189
RETRACTION: Neuroactive Molecules and Growth Factors Modulate Cytoskeletal Protein Expression During Astroglial Cell Proliferation and Differentiation in Culture., PMID:40260586
Cardiovascular Biomarkers: Tools for Precision Diagnosis and Prognosis., PMID:40244022
External validation and comparison of Fetal Medicine Foundation competing-risks model for small-for-gestational-age neonate in the first trimester: multicenter cohort study., PMID:40228140
Isothiocyanates Enhance the Anti-Melanoma Effect of Zebularine Through Modulation of Apoptosis and Regulation of DNMTs' Expression, Chromatin Configuration and Histone Posttranslational Modifications Associated with Altered Gene Expression Patterns., PMID:40136320
Screening for pre-eclampsia using pregnancy-associated plasma protein-A or placental growth factor measurements in blood samples collected at 8-14 weeks' gestation., PMID:40127386
Characterizing the Role of Endocannabinoid Receptor Cnr1 in Mouse Ovarian Granulosa Cells., PMID:40119741
Feasibility of using a multivariate serum biomarker model in early pregnancy to predict gestational hypertension., PMID:40105174
Uterine artery doppler and pregnancy-associated plasma protein-A in pregnancies with fibroids., PMID:40086368
The Proteinase PAPP-A has Deep Evolutionary Roots Outside of the IGF System., PMID:40084812
The relationship between cortical synaptic terminal density marker SV2A and glutamate early in the course of schizophrenia: a multimodal PET and MRS imaging study., PMID:40025026
The Relationship Between Thrombophilia and Modifications in First-Trimester Prenatal Screening Markers., PMID:40005435
N6-Methyladenosine (m6A)-Circular RNA Pappalysin 1 (circPAPPA) from Cashmere Goats: Identification, Regulatory Network and Expression Potentially Regulated by Methylation in Secondary Hair Follicles Within the First Intron of Its Host Gene., PMID:40003062
Non-Melanoma Skin Cancer: Assessing the Systemic Burden of the Disease., PMID:40002296
Circular RNA pappalysin-1 enhances glycolysis via microRNA-656-3p targeting G-protein subunit gamma-5 to promote colon cancer progression., PMID:39951875
Predictive value of prenatal screening markers combined with serum placental growth factor in early pregnancy for preeclampsia., PMID:39926691
Overexpression of metalloproteinase PAPPA accelerates cancer progression and correlates with immune cell infiltration in gastric cancer: insights from bioinformatics and in vitro investigations., PMID:39920676
Influence of trophectoderm biopsy for preimplantation genetic testing in the serum level of first trimester biomarkers., PMID:39920027
Prediction of phenotypes by secretory biomarkers and machine learning in patients with chronic rhinosinusitis., PMID:39911041
Cellular senescence and PAPP-A., PMID:39904113
Maternal cell-free DNA in early pregnancy for preeclampsia screening: a systematic review., PMID:39870917
Cumulative effects of extreme ambient temperatures on placental perfusion and function markers in early pregnancy: Analysis from a birth cohort study., PMID:39862953
Painful diabetic neuropathy is associated with accelerated epigenetic aging., PMID:39847262
Testing of a Culinary Medicine Intervention for Racially/Ethnically Diverse Adults With Type 2 Diabetes., PMID:39818659
Preterm preeclampsia screening and prevention: a comprehensive approach to implementation in a real-world setting., PMID:39815166
Placental biomarkers in second trimester maternal serum are associated with postpartum hemorrhage: a secondary analysis of the NuMoM2b dataset., PMID:39802772
Automatic Single-Cell Harvesting for Fetal Nucleated Red Blood Cell Isolation on a Self-Assemble Cell Array (SACA) Chip., PMID:39770268
Early Prediction of Gestational Diabetes Mellitus and Insulin Therapy Requirement Using First-Trimester PAPP-A and Free β-hCG MoMs Levels: A Retrospective Case-Control Study., PMID:39768648
Pregnancy-associated plasma protein A (PAPP-A) as a first trimester serum biomarker for preeclampsia screening: a systematic review and meta-analysis., PMID:39757003
First-trimester screening and small for gestational age in twin pregnancies: a single center cohort study., PMID:39724362
Identification of Pappa and Sall3 as Gli3 direct target genes acting downstream of cilia signaling in corticogenesis., PMID:39716738
Hysteroscopy improves surgical outcomes of hydatidiform moles while reducing postoperative residuals., PMID:39678565
Downregulation of the NF-κB protein p65 is a shared phenotype among most anti-aging interventions., PMID:39666139
For research use only. Not for human or drug use.
