Catalog No.
YHG43401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Gln183
Predicted molecular weight
23.12 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13185
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
HECH, Heterochromatin protein 1 homolog gamma, Modifier 2 protein, Chromobox protein homolog 3, HP1 gamma, CBX3
lncRNA BBOX1-AS1 regulates the miR-382-5p/CBX3 Signalling pathway to affect the proliferation and apoptosis of glioblastoma cells., PMID:40339498
SETDB1 recruits CBX3 to regulate the SIRT4/PTEN axis, inhibiting autophagy and promoting ischemia-reperfusion-induced kidney injury., PMID:40197868
CBX3 promotes multidrug resistance by suppressing ferroptosis in colorectal carcinoma via the CUL3/NRF2/GPX2 axis., PMID:40089640
Integrated bioinformatics investigation and experimental validation reveals the clinical and biological significance of chromobox family in breast cancer., PMID:39987187
Induction of the p21/CDK6 pathway and alteration of the immune microenvironment by the stem cell marker CBX3 in melanoma., PMID:39934923
Exploring treatment-driven subclonal evolution of prognostic triple biomarkers: Dual gene fusions and chimeric RNA variants in novel subtypes of acute myeloid leukemia patients with KMT2A rearrangement., PMID:39823827
CBX3 contributes to pancreatic adenocarcinoma progression via promoting KIF20A expression., PMID:39735331
CBX3 Downregulates HLTF to Activate PI3K/AKT Signaling Promoting Cholangiocarcinoma., PMID:39601498
Lactate reprograms glioblastoma immunity through CBX3-regulated histone lactylation., PMID:39545414
Comparative Proteomic and Phosphoproteomic Analyses Reveal Molecular Signatures of Myocardial Infarction and Transverse Aortic Constriction in Aged Mouse Models., PMID:39502510
Recurrent hepatocellular carcinoma is associated with the enrichment of MYC targets gene sets, elevated high confidence deleterious mutations and alternative splicing of DDB2 and BRCA1 transcripts., PMID:39486583
Exploring the Role of CBX3 as a Potential Therapeutic Target in Lung Cancer., PMID:39272883
CRISPR screening uncovers nucleolar RPL22 as a heterochromatin destabilizer and senescence driver., PMID:39258545
Pathogenesis of IgA nephropathy as a tissue-specific autoimmune disease., PMID:39066568
Integrated Lactylome Characterization Reveals the Molecular Dynamics of Protein Regulation in Gastrointestinal Cancers., PMID:39018247
Fluorescent Reporter Systems to Investigate Chromatin Effector Proteins in Living Cells., PMID:39012599
NOVEL ACTIVE PROTEINS FOR SEPSIS PROGNOSIS REVEALED THROUGH ScRNA-seq AND QUANTITATIVE PROTEOMICS., PMID:38888471
CK2-dependent degradation of CBX3 dictates replication fork stalling and PARP inhibitor sensitivity., PMID:38781342
CBX3 antagonizes IFNγ/STAT1/PD-L1 axis to modulate colon inflammation and CRC chemosensitivity., PMID:38684864
Identification and validation of cuproptosis and disulfidptosis related genes in colorectal cancer., PMID:38643947
The predictive significance of chromobox family members in prostate cancer in humans., PMID:38427207
Uncovering the role of aquaporin and chromobox family members as potential biomarkers in head and neck squamous cell carcinoma via integrative multiomics and in silico approach., PMID:38358594
Oral bacteria induce IgA autoantibodies against a mesangial protein in IgA nephropathy model mice., PMID:38331476
Large-scale loss-of-function perturbations reveal a comprehensive epigenetic regulatory network in breast cancer., PMID:38062748
m5C modification of LINC00324 promotes angiogenesis in glioma through CBX3/VEGFR2 pathway., PMID:38016610
Targeting CBX3 with a Dual BET/PLK1 Inhibitor Enhances the Antitumor Efficacy of CDK4/6 Inhibitors in Prostate Cancer., PMID:37949681
Presenilin-1-Derived Circular RNAs: Neglected Epigenetic Regulators with Various Functions in Alzheimer's Disease., PMID:37759801
CBX3 promotes clear cell renal carcinoma through PI3K/AKT activation and aberrant immunity., PMID:37674204
Co-amplification of CBX3 with EGFR or RAC1 in human cancers corroborated by a conserved genetic interaction among the genes., PMID:37633946
Mouse HP1γ regulates TRF1 expression and telomere stability., PMID:37598977
PRMT5 triggers glucocorticoid-induced cell migration in triple-negative breast cancer., PMID:37536978
PSMC4 promotes prostate carcinoma progression by regulating the CBX3-EGFR-PI3K-AKT-mTOR pathway., PMID:37436074
An integrative bioinformatics investigation and experimental validation of chromobox family in diffuse large B-cell lymphoma., PMID:37430195
NCAPG is transcriptionally regulated by CBX3 and activates the Wnt/β-catenin signaling pathway to promote proliferation and the cell cycle and inhibit apoptosis in colorectal cancer., PMID:37201048
Characterization of molecular subtypes based on chromatin regulators and identification of the role of NPAS2 in lung adenocarcinoma., PMID:37120564
Comprehensive analysis reveals the value of the expression of chromobox family members for bladder urothelial carcinoma prognosis., PMID:36970607
Inhibition of tiRNA-Gly-GCC ameliorates neointimal formation via CBX3-mediated VSMCs phenotypic switching., PMID:36818350
A Ubiquitous Chromatin Opening Element and DNA Demethylation Facilitate Doxycycline-Controlled Expression during Differentiation and in Transgenic Mice., PMID:36755406
CBX3 promotes breast cancer progression and high level of CBX3 predicts poor prognosis in patients., PMID:36620876
Chromobox Family Proteins as Putative Biomarkers for Breast Cancer Management: A Preliminary Study Based on Bioinformatics Analysis and qRT-PCR Validation., PMID:36605919
Comprehensive analysis of roles of atrial-fibrillation-related genes in lung adenocarcinoma using bioinformatic methods., PMID:36542177
Knockdown of METTL5 inhibits the Myc pathway to downregulate PD-L1 expression and inhibits immune escape of hepatocellular carcinoma cells., PMID:36369791
Mining Transcriptomic Data to Uncover the Association between CBX Family Members and Cancer Stemness., PMID:36361869
CBX Family Members in Two Major Subtypes of Renal Cell Carcinoma: A Comparative Bioinformatic Analysis., PMID:36292141
Systematic investigation of the clinical significance and prognostic value of the CBXs in esophageal cancer., PMID:36221371
Expression and Prognostic Value of Chromobox Family Proteins in Esophageal Cancer., PMID:36140750
CBXs-related prognostic gene signature correlates with immune microenvironment in gastric cancer., PMID:35969177
Bioinformatics role of the WGCNA analysis and co-expression network identifies of prognostic marker in lung cancer., PMID:35844396
Members of the Chromobox Family Have Prognostic Value in Hepatocellular Carcinoma., PMID:35677563
NPM1 promotes cell proliferation by targeting PRDX6 in colorectal cancer., PMID:35659568
For research use only. Not for human or drug use.
