Catalog No.
YHG43201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu177-Ala419
Predicted molecular weight
29.16 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13177
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
S6/H4 kinase, p21-activated kinase 2, p58, PAK-2, PAK2, C-t-PAK2, PAK65, p34, Gamma-PAK, Serine/threonine-protein kinase PAK 2, p27
Using proteomics and single-cell sequencing to analyze the pathogenesis of recurrent implantation failure associated with uterine natural killer cells., PMID:40514455
Inhibition of virally induced TFEB proteasomal degradation as a host-centric therapeutic approach for coronaviral infection., PMID:40465712
An integrated proteomics approach identifies phosphorylation sites on viral and host proteins that regulate West Nile virus infection., PMID:40381193
Chinese Family With Knobloch Syndrome Associated With a Novel PAK2 Variant Leading to Reduced Phosphorylation Levels., PMID:40247748
4D label-free quantitative proteomic and phosphoproteomic profiling of the kidney in rat models of antimyeloperoxidase-associated vasculitis., PMID:40201969
Acetylation of METTL3: A negative regulator of m6A deposition on chromatin-associated regulatory RNAs., PMID:40185074
Mechanical forces trigger invasive behavior in synovial fibroblasts through N-cadherin/ADAM15 -dependent modulation of LncRNA H19., PMID:40118917
Spatial control of m6A deposition on enhancer and promoter RNAs through co-acetylation of METTL3 and H3K27 on chromatin., PMID:40101711
P21-Activated Kinase 2 as a Novel Target for Ventricular Tachyarrhythmias Associated with Cardiac Adrenergic Stress and Hypertrophy., PMID:40068092
TC10 on endosomes regulates the local balance between microtubule stability and dynamics through the PAK2-JNK pathway and promotes axon outgrowth., PMID:40008675
The Important Role of p21-Activated Kinases in Pancreatic Exocrine Function., PMID:40001881
aFGF gene-modified adipose-derived mesenchymal stem cells promote healing of full-thickness skin defects in diabetic rats., PMID:40001190
Antenatal phenotype associated with PAK2 pathogenic variants: bilateral pleural effusion as a warning sign., PMID:39994693
The proteomic landscape of diffuse midline glioma highlights the therapeutic potential of non-histone protein methyltransferases., PMID:39954016
HIV immune evasin Nef enhances allogeneic CAR T cell potency., PMID:39884316
Phenotypic Expansion of Knobloch Syndrome Type 2 in an Individual With a De Novo PAK2 Variant., PMID:39876536
Dynamics of resistance to immunotherapy and TKI in patients with advanced renal cell carcinoma., PMID:39799795
Targeting P21-Activated Kinase 2 as a Novel Therapeutic Approach to Mitigate Endoplasmic Reticulum Stress in Heart Failure With Preserved Ejection Fraction., PMID:39791428
Regulation of Cancer Metastasis by PAK2., PMID:39769207
Regulation of Vascular Injury and Repair by P21-Activated Kinase 1 and P21-Activated Kinase 2: Therapeutic Potential and Challenges., PMID:39766303
PAK2 as a therapeutic target in cancer: Mechanisms, challenges, and future perspectives., PMID:39694422
Imatinib is effective in some PDGFRA/B-negative hypereosinophilic syndromes: A step closer to unveiling underlying mechanisms., PMID:39468717
Phase II trial of imatinib mesylate in patients with PDGFRA/B-negative hypereosinophilic syndrome., PMID:39389908
The up-regulation of PAK2 indicates unfavorable prognosis in patients with serous epithelial ovarian cancer and contributes to paclitaxel resistance in ovarian cancer cells., PMID:39350056
Physical exercise-induced circAnks1b upregulation promotes protective endoplasmic reticulum stress and suppresses apoptosis via miR-130b-5p/Pak2 signaling in an ischemic stroke model., PMID:39328024
Integrated ceRNAs regulating relationship and bioinformatics analysis to study the molecular mechanisms of the inhibition of puerarin on bladder cancer cell., PMID:39133645
Synergistic effect of PAK and Hippo pathway inhibitor combination in NF2-deficient Schwannoma., PMID:39083549
O-demethyl galantamine alters protein expression in cerebellum of 5xFAD mice., PMID:39050707
Study of the genetic association between selected 3q29 region genes and schizophrenia and autism spectrum disorder in the Japanese population., PMID:38962417
New kinase-deficient PAK2 variants associated with Knobloch syndrome type 2., PMID:38894571
PAK2 promotes proliferation, migration, and invasion of lung squamous cell carcinoma through LIMK1/cofilin signaling pathway., PMID:38828848
Genetic mutation and immune infiltration in embryonal tumor with multilayered rosettes., PMID:38802706
Porocarcinomas with PAK1/2/3 fusions: a series of 12 cases., PMID:38785043
A de novo variant in PAK2 detected in an individual with Knobloch type 2 syndrome., PMID:38712026
Kinase activities in pancreatic ductal adenocarcinoma with prognostic and therapeutic avenues., PMID:38650175
ACSL4 promotes malignant progression of Hepatocellular carcinoma by targeting PAK2 transcription., PMID:38615921
The protein composition of exosomes released by prostate cancer cells is distinctly regulated by androgen receptor-antagonists and -agonist to stimulate growth of target cells., PMID:38589887
Engineered hsa-miR-455-3p-Abundant Extracellular Vesicles Derived from 3D-Cultured Adipose Mesenchymal Stem Cells for Tissue-Engineering Hyaline Cartilage Regeneration., PMID:38508211
Identification of microRNA-mRNA Regulatory Networks with Therapeutic Values in Alzheimer's Disease by Bioinformatics Analysis., PMID:38427479
Icariin Attenuates Human Renal Tubular Epithelial Cell Senescence by Targeting PAK2 via miR-23b-3p., PMID:38375837
Molecular mechanisms of pancreatic cancer liver metastasis: the role of PAK2., PMID:38343537
Anticancer mechanism of coumarin-based derivatives., PMID:38340509
Whole exome sequencing and polygenic assessment of a Swedish cohort with severe developmental language disorder., PMID:38300321
PAK inhibitor FRAX486 decreases the metastatic potential of triple-negative breast cancer cells by blocking autophagy., PMID:38110664
PAK2 is necessary for myelination in the peripheral nervous system., PMID:38079473
A novel pipeline for prioritizing cancer type-specific therapeutic vulnerabilities using DepMap identifies PAK2 as a target in head and neck squamous cell carcinomas., PMID:37997254
Case report: Blotchy skin in a puffy neonate: is there a new association?, PMID:37808560
Comprehensive Genomic Analysis of Puerarin in Inhibiting Bladder Urothelial Carcinoma Cell Proliferation and Migration., PMID:37694778
Gastrodin ameliorates cognitive dysfunction in diabetes by inhibiting PAK2 phosphorylation., PMID:37610708
Gene fusions in poroma, porocarcinoma and related adnexal skin tumours: An update., PMID:37609771
For research use only. Not for human or drug use.
