Catalog No.
YHG43001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Val560-Glu793
Predicted molecular weight
50.21 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13164
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
MAP kinase 7, Extracellular signal-regulated kinase 5, PRKM7, BMK1, Big MAP kinase 1, BMK-1, ERK-5, ERK5, Mitogen-activated protein kinase 7, MAPK7, MAPK 7
Physiochemical and transcriptomics of exotic holstein friesian cattle in Pakistani subtropics., PMID:40478316
Signaling pathways underlying extracellular trap formation induced by Vibrio alginolyticus in Strongylocentrotus intermedius., PMID:40425409
Anti-cancer Effects of 1,4-Dialkoxynaphthalene-Imidazolium Salt Derivatives through ERK5 kinase activity inhibition., PMID:40254676
Targeting the RBM39-MEK5 axis synergizes with bortezomib to inhibit the malignant growth of multiple myeloma., PMID:40048740
Mapk7 enhances osteogenesis and suppresses adipogenesis by activating Lrp6/β-catenin signaling axis in mesenchymal stem cells., PMID:40000807
The MEK5/ERK5 pathway promotes the activation of the Hedgehog/GLI signaling in melanoma cells., PMID:39998753
A first-in-class selective inhibitor of ERK1/2 and ERK5 overcomes drug resistance with a single-molecule strategy., PMID:39979271
MEK5-ERK5 pathway mediates mitophagy by regulating Nur77 to promote tumorigenesis of osteosarcoma cells., PMID:39972514
The effect of low energy LED red light on osteogenetic differentiation of periodontal ligament stem cell via the ERK5 signal pathway., PMID:39873791
TXN promotes tumorigenesis by activating the ERK1/2 and ERK5 signaling pathways regulating c-Myc in non-small cell lung cancer., PMID:39571701
Low fluid shear stress promotes chondrocyte proliferation and extracellular matrix secretion by downregulating mir-143-3p and activating the ERK5/KLF4 signaling pathway., PMID:39532925
Transcriptome analysis of the cytokine storm-related genes among the subtypes of idiopathic multicentric Castleman disease., PMID:39462545
Low shear stress protects chondrocytes from IL-1β-induced apoptosis by activating ERK5/KLF4 signaling and negatively regulating miR-143-3p., PMID:39402582
Macrophage MAPK7/AhR/STAT3 Signaling Mediates Mitochondrial ROS Burst and Enterohepatic Inflammatory Responses Induced by Deoxynivalenol Relevant to Low-Dose Exposure in Children., PMID:39376183
ERK5 suppression overcomes FAK inhibitor resistance in mutant KRAS-driven non-small cell lung cancer., PMID:39271958
Insight in the (Phospho)proteome of Vascular Smooth Muscle Cells Derived From Patients With Abdominal Aortic Aneurysm Reveals Novel Disease Mechanisms., PMID:39206541
ERK5 promotes autocrine expression to sustain mitogenic balance for cell fate specification in human pluripotent stem cells., PMID:39151429
ERK5 mediates pro-tumorigenic phenotype in non-small lung cancer cells induced by PGE2., PMID:39128596
Revealing Dynamics of Protein Phosphorylation: A Study on the Cashmere Fineness Disparities in Liaoning Cashmere Goats., PMID:39117978
Conserved gatekeeper methionine regulates the binding and access of kinase inhibitors to ATP sites of MAP2K1, 4, and 7: Clues for developing selective inhibitors., PMID:39111728
Statins enhance extracellular release of hepatitis C virus particles through ERK5 activation., PMID:39073705
The ERK5 pathway in BRAFV600E melanoma cells plays a role in development of acquired resistance to dabrafenib but not vemurafenib., PMID:38977937
Importin subunit beta-1 mediates ERK5 nuclear translocation, and its inhibition synergizes with ERK5 kinase inhibitors in reducing cancer cell proliferation., PMID:38965815
ERK5 Activity Prevention Improves the Antitumor Efficacy of Fluvastatin on Thymic Carcinoma., PMID:38821590
Regulation of TAK-TAB Complex Activation through Ubiquitylation., PMID:38812304
Bone and Extracellular Signal-Related Kinase 5 (ERK5)., PMID:38785963
Latent-Transforming Growth Factor β-Binding Protein 1/Transforming Growth Factor β1 Complex Drives Antitumoral Effects upon ERK5 Targeting in Melanoma., PMID:38705382
Baicalin restore intestinal damage after early-life antibiotic therapy: the role of the MAPK signaling pathway., PMID:38663526
An ERK5-PFKFB3 axis regulates glycolysis and represents a therapeutic vulnerability in pediatric diffuse midline glioma., PMID:38113141
Proteomic Characterization Identifies Clinically Relevant Subgroups of Gastrointestinal Stromal Tumors., PMID:37995868
Identification of mitogen-activated protein kinase 7 inhibitors from natural products: Combined virtual screening and dynamic simulation studies., PMID:37956676
Effects of obesity, and of weight loss following bariatric surgery, on methylation of DNA from the rectal mucosa and in cell-free DNA from blood., PMID:37714902
Computational analysis of regulatory regions in human protein kinases., PMID:37632170
The significance of ERK5 catalytic-independent functions in disease pathways., PMID:37601096
ERK5 Cooperates With MEF2C to Regulate Nr4a1 Transcription in MA-10 and MLTC-1 Leydig Cells., PMID:37539861
Identification of a Novel ERK5 (MAPK7) Inhibitor, MHJ-627, and Verification of Its Potent Anticancer Efficacy in Cervical Cancer HeLa Cells., PMID:37504304
Functional Analysis and Clinical Importance of ATP1A1 in Colon Cancer., PMID:37407874
Sphingosine 1-phosphate elicits a ROS-mediated proinflammatory response in human endometrial stromal cells via ERK5 activation., PMID:37389926
Etiopathogenic role of ERK5 signaling in sarcoma: prognostic and therapeutic implications., PMID:37332046
The Investigation of MAPK7 Gene Variations in Colorectal Cancer Risk., PMID:36881097
L-Fucose inhibits the progression of cholangiocarcinoma by causing microRNA-200b overexpression., PMID:36728287
Extracellular signal-Regulated Kinase 5 (ERK5) is required for the Yes-associated protein (YAP) co-transcriptional activity., PMID:36650140
Bioinformatic Analysis of Genetic Factors from Human Blood Samples and Postmortem Brains in Parkinson's Disease., PMID:36593912
The Integration of Proteome-Wide PTM Data with Protein Structural and Sequence Features Identifies Phosphorylations that Mediate 14-3-3 Interactions., PMID:36402225
OXTRHigh stroma fibroblasts control the invasion pattern of oral squamous cell carcinoma via ERK5 signaling., PMID:36045118
Green tea epigallocatechin gallate suppresses 3T3-L1 cell growth via microRNA-143/MAPK7 pathways., PMID:35894140
Overexpression of TRAF4 promotes lung cancer growth and EGFR-dependent phosphorylation of ERK5., PMID:35748027
Machine Learning Identifies Pan-Cancer Landscape of Nrf2 Oxidative Stress Response Pathway-Related Genes., PMID:35242279
Pitavastatin maintains MAPK7 expression and alleviates angiotensin II-induced vascular endothelial cell inflammation and injury., PMID:35069813
Anticancer Activities of 9-chloro-6-(piperazin-1-yl)-11H-indeno[1,2-c] quinolin-11-one (SJ10) in Glioblastoma Multiforme (GBM) Chemoradioresistant Cell Cycle-Related Oncogenic Signatures., PMID:35008426
For research use only. Not for human or drug use.
