Catalog No.
YHG42401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu252-Cys501
Predicted molecular weight
30.35 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13153
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Alpha-PAK, p65-PAK, PAK-1, Serine/threonine-protein kinase PAK 1, p21-activated kinase 1, PAK1
Increased Fascin1 and Pak1 Expressions Enhance Age-Associated B-Cell Actin Cytoskeleton Remodeling and Motility., PMID:40500987
Negative feedback equalizes polarity sites in a multi-budding yeast., PMID:40482649
Focal Adhesion Kinase Orchestrates GLUT4 Translocation and Glucose Uptake via Cytoskeletal Turnover in Primary Adipocytes., PMID:40396386
N6-methyladenosine RNA base modification regulates NKG2D-dependent and cytotoxic genes expression in natural killer cells., PMID:40389988
The Role of the p21-Activated Kinase Family in Tumor Immunity., PMID:40332759
Transcriptome Analysis of Human Pancreatic Stellate Cells Co-cultured With PAK1-Modulated Cells Revealed the Role of Cytokine Pathway in Tumor Microenvironment., PMID:40314739
The phosphorylation of Pak1 by Erk1/2 to drive cell migration requires Arl4D acting as a scaffolding protein., PMID:40309925
VAV2 exists in extrachromosomal circular DNA and contributes Enzalutamide resistance of prostate cancer via stabilization of AR/ARv7., PMID:40303312
Knockdown of PAK1IP1 can Induce Pyroptosis to Inhibit the Progression of Hepatocellular Carcinoma., PMID:40302327
The kinase domain of TRPM7 interacts with PAK1 and regulates pancreatic cancer cell epithelial-to-mesenchymal transition., PMID:40274768
Spatiotemporal expression of Nischarin in developing rat brain mediates neuronal migration via the PAK1/LIMK1/cofilin pathway., PMID:40262669
Phillyrin counters β2 integrin-mediated neutrophil adhesion and chemotaxis to alleviate endotoxin-induced acute lung injury in neonatal rats., PMID:40210127
JEV NS1' protein enhances cell-to-cell viral spread by inducing the formation of tunneling nanotubes., PMID:40187292
LUZP1 Regulates Dendritic Spine Maturation and Synaptic Plasticity in the Hippocampal Dentate Gyrus of Mice., PMID:40180573
P21-Activated Kinase 1 (PAK1) Modulates Therapeutic Response to Ionizing Radiation in Head and Neck Squamous Cell Carcinoma Cells., PMID:40099538
Pak1 dysregulates pyruvate metabolism in PDAC cells by exerting a phosphorylation-mediated regulatory effect on PDHA1., PMID:40090587
RAC1 promotes the occurrence and development of tongue squamous cell carcinoma by regulating RAC1/PAK1/LIMK1 signaling pathway., PMID:40087375
Phosphoproteomics identifies determinants of PAK inhibitor sensitivity in leukaemia cells., PMID:40082888
Integrated spatial multi-omics profiling of Fusobacterium nucleatum in breast cancer unveils its role in tumour microenvironment modulation and cancer progression., PMID:40070022
p21-Activated Kinase 1 (Pak1) as an Element in Functional and Dysfunctional Interplay Among the Myocardium, Adipose Tissue, and Pancreatic Beta Cells., PMID:40065530
A p.N92K variant of the GTPase RAC3 disrupts cortical neuron migration and axon elongation., PMID:40015633
The Important Role of p21-Activated Kinases in Pancreatic Exocrine Function., PMID:40001881
Modulating PAK1: Accessory Proteins as Promising Therapeutic Targets., PMID:40001545
EGCG Mitigates Apoptosis of Lens Epithelial Cells in Age-Related Cataract via the PAK1/Cleaved Caspase-3 Pathway., PMID:39949100
Nexinhib20 inhibits JFC1-mediated mobilization of a subset of CD11b/CD18+ vesicles decreasing integrin avidity, but does not inhibit Rac1., PMID:39883854
Ginsenoside Rh2(S) maintains cytoskeleton homeostasis and inhibits pyroptosis to resist cisplatin-induced cardiotoxicity through FGFR1/HRAS axis., PMID:39879704
Identification of Potential Selective PAK4 Inhibitors Through Shape and Protein Conformation Ensemble Screening and Electrostatic-Surface-Matching Optimization., PMID:39852144
Identifying and Targeting Key Driver Genes for Collagen Production within the 11q13/14 Breast Cancer Amplicon., PMID:39836438
Simulation studies to identify high-affinity probiotic peptides for inhibiting PAK1 gastric cancer protein: A comparative approach., PMID:39818002
Novel Combination Therapy Targeting Oncogenic Signaling Kinase P21-Activated Kinase 1 and Chemotherapeutic Drugs Against Triple-Negative Breast Cancer., PMID:39803692
S6K1 is a Targetable Vulnerability in Tumors Exhibiting Plasticity and Therapy Resistance., PMID:39781466
Regulation of Vascular Injury and Repair by P21-Activated Kinase 1 and P21-Activated Kinase 2: Therapeutic Potential and Challenges., PMID:39766303
Nox1/PAK1 is required for angiotensin II-induced vascular inflammation and abdominal aortic aneurysm formation., PMID:39721498
Structural and functional alterations of neurons derived from sporadic Alzheimer's disease hiPSCs are associated with downregulation of the LIMK1-cofilin axis., PMID:39702316
Longitudinal phosphoproteomics reveals the PI3K-PAK1 axis as a potential target for recurrent colorectal liver metastases., PMID:39689713
The p.R66W Variant in RAC3 Causes Severe Fetopathy Through Variant-Specific Mechanisms., PMID:39682779
Neuronal PLPP/CIN exaggerates the immune response of hippocampal microglia to LPS challenge dependent on PAK1-NF-κB-COX-2 signaling pathway., PMID:39581524
Comprehensive multi-omics analysis elucidates colchicine-induced toxicity mechanisms and unveils the therapeutic potential of MLN4924 and kinase inhibitors., PMID:39567751
Staphylococcus aureus can use an alternative pathway to be internalized by osteoblasts in absence of β1 integrins., PMID:39562631
Application of stress granule core element G3BP1 in various diseases: A review., PMID:39515684
Spatio-temporal localization of P21-activated kinase in endometrial cancer., PMID:39506238
Modelling quiescence exit of neural stem cells reveals a FOXG1-FOXO6 axis., PMID:39499086
Testosterone acts through the membrane protein GPRC6A to cause cardiac edema in zebrafish embryos., PMID:39479956
[Effects of Down-Regulation of PAK1 on Differentiation and Apoptosis of MPN Cells with MPLW515L Gene Mutation and Survival of 6133/MPL Mice]., PMID:39479834
Beta cell-specific PAK1 enrichment ameliorates diet-induced glucose intolerance in mice by promoting insulin biogenesis and minimising beta cell apoptosis., PMID:39404845
FYCO1 regulates autophagy and senescence via PAK1/p21 in cataract., PMID:39395618
In-silico identification of therapeutic targets in pancreatic ductal adenocarcinoma using WGCNA and Trader., PMID:39375436
Ladinin-1 in actin arcs of oral squamous cell carcinoma is involved in cell migration and epithelial phenotype., PMID:39354061
Phlpp1 alters the murine chondrocyte phospho-proteome during endochondral bone formation., PMID:39349089
Inhibition of NAMPT by PAK4 Inhibitors., PMID:39337621
For research use only. Not for human or drug use.
