Catalog No.
YHG41701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asn95-Lys434
Predicted molecular weight
41.46 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13133
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Nuclear receptor subfamily 1 group H member 3, Oxysterols receptor LXR-alpha, NR1H3, Liver X receptor alpha, LXRA
Uremic toxin receptor NR1H3 contributes to hyperlipidemia- and chronic kidney disease-accelerated vascular inflammation, which is partially suppressed by novel YBX2 anti-ROS pathway., PMID:40505347
A holistic computational exploration of AZD7762 as a potent selective modulator of LXRα, LXRβ and FXR: An underexplored pathway in cancer therapeutics., PMID:40472507
27-Hydroxycholesterol in cancer development and drug resistance., PMID:40401382
LXR pathway drives hormonal response intensity in polycystic ovary syndrome., PMID:40399491
Mitochondrial dysfunction fuels drug resistance in adult T-cell acute lymphoblastic leukemia., PMID:40369632
Research Progress on the Mechanism of Bile Acids and Their Receptors in Depression., PMID:40362260
A Novel Rexinoid Agonist, UAB116, Decreases Metastatic Phenotype in Hepatoblastoma by Inhibiting the Wnt/β-Catenin Pathway via Upregulation of TRIM29., PMID:40362175
Eliminating myeloid-derived suppressor cells alleviates immunosuppression and reduces susceptibility to secondary infections in a two-hit sepsis model., PMID:40339353
The Synthetic LXR Agonist GW3965 Attenuates Phosgene-Induced Acute Lung Injury Through the Modulation of PI3K/Akt and NF-κB Signalling Pathways., PMID:40312968
Exploring the Roles of Liver X Receptors in Lipid Metabolism and Immunity in Atherosclerosis., PMID:40305368
Role of oxysterol 4β-hydroxycholesterol and liver X receptor alleles in pre-eclampsia., PMID:40298034
Qingre Sanjie Formula alleviates atherosclerosis by promoting LXR-α/ABCG5/G8-mediated reverse cholesterol transport and bile acid synthesis., PMID:40286749
Intestinal Activation of LXRα Counteracts Metabolic-Associated Steatohepatitis Features in Mice., PMID:40284213
Impact of 1,2-Bis (2,4,6-Tribromophenoxy) Ethane on Liver Metabolism and Intestinal Health in Zebrafish: Role of the Liver X Receptor., PMID:40277015
A signpost to guide the key therapeutic components of Aralia continentalis Kitag roots in treating T2DM-derived heart attack, and diabetic nephropathy via systems biology concept., PMID:40274257
HDL Nanodiscs Loaded with Liver X Receptor Agonist Decreases Tumor Burden and Mediates Long-term Survival in Mouse Glioma Model., PMID:40249282
Role for the liver X receptor agonist 22-ketositosterol in preventing disease progression in an Alzheimer's disease mouse model., PMID:40233928
Inactivation of microglial LXRβ in early postnatal mice impairs microglia homeostasis and causes long-lasting cognitive dysfunction., PMID:40208947
Dietary oleic acid drives obesogenic adipogenesis via modulation of LXRα signaling., PMID:40208790
Inhibition of LXR Signaling in Human Foam Cells Impairs Macrophage-to-Endothelial Cell Cross Talk and Promotes Endothelial Cell Inflammation., PMID:40207367
Role of liver X receptor in multiple sclerosis: A long furtive life behind a barrier., PMID:40185420
LXR agonists induces GSDME-mediated pyroptosis in tumors through alters the integrity of the MOM to activates Caspase-4/APAF-1 pyroptosome., PMID:40154703
MAIT Cells Promote Cholesterol Excretion Pathways Mitigating Atherosclerosis., PMID:40135347
Uncovering α-Selectivity for Liver X Receptor Agonists for Lipotoxic Cancer Therapies., PMID:40127224
Damiana (Turnera diffusa) Reduces Adipocyte Cell Differentiation and Ameliorates Myocyte Glucose Uptake., PMID:40125913
Global deletion of the LXR-regulated gene EEPD1 reveals macrophage-specific changes in lipid metabolism and cholesterol efflux., PMID:40121793
Mechanism of liver x receptor alpha in intestine, liver and adipose tissues in metabolic associated fatty liver disease., PMID:40112983
Is IDOL an Ideal Target for Treating Atherosclerosis?, PMID:40109259
Action of 3-Hydroxy-3-Methylglutaryl-CoA Reductase Inhibitors on ABCA-1 protein (ATP-Binding Cassette Transporter-1) in endothelial cells stimulated with uremic serum., PMID:40108621
CKN reduces TLR4-mediated inflammation and cerebral I/R injury by activating the LXRα/ABCA1 pathway in microglia., PMID:40107493
Protective functions of liver X receptor α on calcified aortic valve: involvement of regulating endoplasmic reticulum-mediated osteogenic differentiation., PMID:40088465
LXRα agonists ameliorates acute rejection after liver transplantation via ABCA1/MAPK and PI3K/AKT/mTOR signaling axis in macrophages., PMID:40087552
Hypercholesterolemia-induced LXR signaling in smooth muscle cells contributes to vascular lesion remodeling and visceral function., PMID:40035761
Targeting the ceramidase ACER3 attenuates cholestasis in mice by mitigating bile acid overload via unsaturated ceramide-mediated LXRβ signaling transduction., PMID:40025008
EHDPP impairs intestinal microbiota homeostasis and induces placental injury through choline mediated gut-placenta axis., PMID:40007358
Development of human growth hormone-treated chimeric mice with humanized livers for an evaluation model of drug-induced fatty liver disease., PMID:39979474
Jiajian Shuyu pills effectively ameliorate cognitive impairment via regulating the inflammation of microglia in an Alzheimer's disease mouse model., PMID:39971019
Vitamin D reduces VSMC foam cell formation and protects against AS progression., PMID:39960435
Soyasapogenol C: A novel liver X receptor α Agonist that mitigates cholesterol accumulation in diabetic kidney disease., PMID:39946984
Ganaxolone Reverses the Effect of Amyloid β-Induced Neurotoxicity by Regulating the Liver X Receptor Expression in APP Transfected SH-SY5Y Cells and Murine Model of Alzheimer's Disease., PMID:39936324
Liver-X receptor β-selective agonist CE9A215 regulates Alzheimer's disease-associated pathology in a 3xTg-AD mouse model., PMID:39919463
Isovaleroylbinankadsurin A ameliorates atherosclerosis and restenosis by promoting LXRα signaling pathway and inhibiting TGF-β1 and FHL1 signaling pathways., PMID:39914064
Broccoli (Brassica oleracea L. var. italica Planch) alleviates metabolic-associated fatty liver disease through regulating gut flora and lipid metabolism via the FXR/LXR signaling pathway., PMID:39903517
Liver X Receptor-Growth Differentiation Factor 15 Activation Drives Profibrotic Changes in the Aqueous Outflow Tract of Uveitic Glaucoma., PMID:39892779
Screening of key genes involved in endometritis in cows and the regulatory role of CD83 in bovine endometrial epithelial cells., PMID:39892172
Upregulation of LXRβ/ABCA1 pathway alleviates cochlear hair cell senescence of C57BL/6 J mice via reducing lipid droplet accumulation., PMID:39890652
Anti-atherosclerotic effects of natural compounds targeting lipid metabolism and inflammation: Focus on PPARs, LXRs, and PCSK9., PMID:39877131
A mutation in LXRα uncovers a role for cholesterol sensing in limiting metabolic dysfunction-associated steatohepatitis., PMID:39875396
Reduction of Low-Density Lipoprotein Cholesterol by Mesenchymal Stem Cells in a Mouse Model of Exogenous Cushing's Syndrome., PMID:39873947
The Liver X Receptor Promotes Immune Homeostasis via Controlled Activation of the Innate Immune System in the Liver., PMID:39858420
For research use only. Not for human or drug use.
