Catalog No.
YHG38101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys285-Asp443
Predicted molecular weight
20.40 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13043
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
KRS2, STK4, MST1/N, MST1/C, MST1, MST-1, Serine/threonine-protein kinase 4, Mammalian STE20-like protein kinase 1, STE20-like kinase MST1, Serine/threonine-protein kinase Krs-2
Proteomics and Phosphoproteomics Revealed Dysregulated Kinases and Potential Therapy for Liver Fibrosis., PMID:40368138
Dual inhibition of Mst1 and Mst2 exacerbates cardiac dysfunction during pressure overload stress in mice., PMID:39892959
Activation of the conserved Hippo kinases by inflammasome-triggered proteolytic cleavage controls programmed cell death in macrophages., PMID:39883842
miR-301a-mediated crosstalk between the Hedgehog and HIPPO/YAP signaling pathways promotes pancreatic cancer., PMID:39846248
Increased Expression of MST1 in Patients With Epilepsy and in a Rat Model of Epilepsy., PMID:39729046
Activation of MST1 protects filtration barrier integrity of diabetic kidney disease in mice through restoring the tight junctions of glomerular endothelial cells., PMID:39643641
Hippo cooperates with p53 to regulate lung airway mucous cell metaplasia., PMID:39428818
Rapid identification of primary atopic disorders (PAD) by a clinical landmark-guided, upfront use of genomic sequencing., PMID:39381601
Effect of the polyphenol flavonoids fisetin and quercetin on the adipogenic differentiation of human mesenchymal stromal cells., PMID:39364538
Case Report of Two Independent Moroccan Families with Syndromic Epidermodysplasia Verruciformis and STK4 Deficiency., PMID:39339890
Inhibiting endothelial cell Mst1 attenuates acute lung injury in mice., PMID:39253972
Proteomic analysis of cardiovascular disease-associated proteins in Korean patients with moderate-to-severe atopic dermatitis., PMID:39220465
YAP activation in liver macrophages via depletion of MST1/MST2 enhances liver inflammation and fibrosis in MASLD., PMID:39215627
Nc-RNA-mediated low expression of AZIN1 correlated with unfavorable prognosis in kidney renal clear cell carcinoma., PMID:39140420
SNORD88B-mediated WRN nucleolar trafficking drives self-renewal in liver cancer initiating cells and hepatocarcinogenesis., PMID:39112443
Epidermodysplasia Verruciformis and Vδ2 γδ T-cell Expansion in STK4 Deficiency., PMID:39110273
Mst1-mediated phosphorylation of FoxO1 and C/EBP-β stimulates cell-protective mechanisms in cardiomyocytes., PMID:39060225
Hippo kinases Mst1 and Mst2 maintain NK cell homeostasis by orchestrating metabolic state and transcriptional activity., PMID:38898027
MST1 knockdown inhibits osteoarthritis progression through Parkin-mediated mitophagy and Nrf2/NF-κB signalling pathway., PMID:38842136
Hippo and PI5P4K signaling intersect to control the transcriptional activation of YAP., PMID:38805583
Inhibiting Hippo pathway kinases releases WWC1 to promote AMPAR-dependent synaptic plasticity and long-term memory in mice., PMID:38687825
Comprehensive DNA methylation profiling by MeDIP-NGS identifies potential genes and pathways for epithelial ovarian cancer., PMID:38627856
The Hippo kinases control inflammatory Hippo signaling and restrict bacterial infection in phagocytes., PMID:38624208
The Mst1/2-BNIP3 axis is required for mitophagy induction and neuronal viability under mitochondrial stress., PMID:38443598
Inhibition of MST1 ameliorates neuronal apoptosis via GSK3β/β-TrCP/NRF2 pathway in spinal cord injury accompanied by diabetes., PMID:38430683
Activation of the YAP/KLF5 transcriptional cascade in renal tubular cells aggravates kidney injury., PMID:38414248
A unique STK4 mutation truncating only the C-terminal SARAH domain results in a mild clinical phenotype despite severe T cell lymphopenia: Case report., PMID:38361950
Association Study between SNPs in MST1 and MST2 and H. pylori Infection as well as Noncardia Gastric Carcinogenesis., PMID:38295774
Mammalian STE20-like kinase 1 inhibits synoviocytes activation in rheumatoid arthritis through mitochondrial dysfunction mediated by SIRT3/mTOR axis., PMID:38265688
Inactivation of MST1/2 Controls Macrophage Polarization to Affect Macrophage-Related Disease via YAP and Non-YAP Mechanisms., PMID:38250155
Clinical heterogeneity in families with multiple cases of inborn errors of immunity., PMID:38184287
[Characterization the response of Chlamydomonas reinhardtii serine/threonine protein kinase mutant to blue light]., PMID:38013184
MAP4K2 connects the Hippo pathway to autophagy in response to energy stress., PMID:37937799
Saikosaponin-b2 Inhibits Primary Liver Cancer by Regulating the STK4/IRAK1/NF-κB Pathway., PMID:37893233
Smurf1 polyubiquitinates on K285/K282 of the kinases Mst1/2 to attenuate their tumor-suppressor functions., PMID:37890777
STK4 is a prognostic biomarker correlated with immune infiltrates in clear cell renal cell carcinoma., PMID:37870765
STK4 deficiency and epidermodysplasia verruciformis-like lesions: A case report., PMID:37515487
Transcription factor TOX maintains the expression of Mst1 in controlling the early mouse NK cell development., PMID:37153735
MST1 downregulates TAZ tumor suppressor protein in multiple myeloma and is a potential therapeutic target., PMID:37137439
Ginsenoside Rh2 attenuates the progression of non-small cell lung cancer by sponging miR-28-5p/STK4 axis and inactivating Wnt/β-catenin signaling., PMID:37081781
Hippo/YAP1 inhibition by verteporfin attenuates osteophyte formation in a mouse surgical osteoarthritis model., PMID:37027967
Stk4, a key regulator in regulatory T cells homeostasis activity?, PMID:37017139
Effective Reversal of Macrophage Polarization by Inhibitory Combinations Predicted by a Boolean Protein-Protein Interaction Model., PMID:36979068
Comparative genomics studies on the stk gene family in vertebrates: From the bighead carp (Hypophthalmichthys nobilis) genome., PMID:36858329
Potent and Selective Biaryl Amide Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1)., PMID:36655134
Mst1 attenuates myocardial ischemia/reperfusion injury following heterotopic heart transplantation in mice through regulating Keap1/Nrf2 axis., PMID:36646002
Mst1-mediated phosphorylation of Nur77 improves the endometrial receptivity in human and mice., PMID:36623453
STK4 protein expression pattern follows different trends in endometrioid and serous endometrial adenocarcinoma upon tumor progression., PMID:36550267
Hematopoietic stem cell transplantation in serine/threonine kinase 4 (STK4) deficiency: Report of two cases and literature review., PMID:36394186
A/(H1N1) pdm09 NS1 promotes viral replication by enhancing autophagy through hijacking the IAV negative regulatory factor LRPPRC., PMID:36300799
For research use only. Not for human or drug use.
