Catalog No.
YHG38001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Ser152
Predicted molecular weight
20.33 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13042
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CDC16, CDC16 homolog, APC6, Cell division cycle protein 16 homolog, CDC16Hs, ANAPC6, Anaphase-promoting complex subunit 6, Cyclosome subunit 6
Mechanistic insights into the interaction between optineurin with RAB8A., PMID:40395537
Phosphate-binding pocket on cyclin B governs CDK substrate phosphorylation and mitotic timing., PMID:40341598
Identification of Rab GTPase-Activating Proteins Required for Tubular Endosome Formation., PMID:40241313
Genome-Wide Analysis for TLDc domain-containing genes in Oryza sativa., PMID:40163961
EPG-5 regulates TGFB/TGF-β and WNT signalling by modulating retrograde endocytic trafficking., PMID:40152605
c-Jun promotes neuroblastoma cell differentiation by inhibiting APC formation via CDC16 and reduces neuroblastoma malignancy., PMID:40149013
SENP3-FIS1 axis promotes mitophagy and cell survival under hypoxia., PMID:39638786
TBC1D15-regulated mitochondria-lysosome membrane contact exerts neuroprotective effects by alleviating mitochondrial calcium overload in seizure., PMID:39390030
Characterization of temperature-sensitive alleles of Schizosaccharomyces pombe septation initiation network components., PMID:38989013
TBC1D24 is likely to regulate vesicle trafficking in glia-like non-sensory epithelial cells of the cochlea., PMID:38869222
A comprehensive analysis of the oncogenic and prognostic role of TBC1Ds in human hepatocellular carcinoma., PMID:38766486
TBC9, an essential TBC-domain protein, regulates early vesicular transport and IMC formation in Toxoplasma gondii., PMID:38762629
Systematic characterization of all Toxoplasma gondii TBC domain-containing proteins identifies an essential regulator of Rab2 in the secretory pathway., PMID:38713739
Hepatitis B virus core protein as a Rab-GAP suppressor driving liver disease progression., PMID:38670853
Human V-ATPase function is positively and negatively regulated by TLDc proteins., PMID:38593795
Loss of TBC1D2B causes a progressive neurological disorder with gingival overgrowth., PMID:38374468
TLDc Domain-Containing Genes in Autism Spectrum Disorder: New Players in the Oxidative Stress Response., PMID:37958785
Toxoplasma gondii encodes an array of TBC-domain containing proteins including an essential regulator that targets Rab2 in the secretory pathway., PMID:37398139
Alternative glucose uptake mediated by β-catenin/RSK1 axis under stress stimuli in mammalian cells., PMID:37321415
Identification of immune cells infiltrating in hippocampus and key genes associated with Alzheimer's disease., PMID:36915078
CHAMP1-related disorders: pathomechanisms triggered by different genomic alterations define distinct nosological categories., PMID:36797464
Phosphorylation of PBX2, a novel downstream target of mTORC1, is determined by GSK3 and PP1., PMID:36477205
Small GTPase FoSec4-Mediated Protein Secretion Is Important for Polarized Growth, Reproduction and Pathogenicity in the Banana Fusarium Wilt Fungus Fusarium odoratissimum., PMID:36012867
Adult-Onset Focal Segmental Glomerulosclerosis With Steroid-Dependent Nephrotic Syndrome Caused by a Novel TBC1D8B Variant: A Case Report and Literature Review., PMID:35970429
An analysis of the significance of the Tre2/Bub2/CDC 16 (TBC) domain protein family 8 in colorectal cancer., PMID:35918393
TBC1D24-related familial infantile multifocal myoclonus: Description of a new Chinese pedigree with a 20 year follow up., PMID:35413638
Restriction factor screening identifies RABGAP1L-mediated disruption of endocytosis as a host antiviral defense., PMID:35320721
DEPDC1B Promotes Melanoma Angiogenesis and Metastasis through Sequestration of Ubiquitin Ligase CDC16 to Stabilize Secreted SCUBE3., PMID:35088579
Genome-Wide Association Study of Growth Performance and Immune Response to Newcastle Disease Virus of Indigenous Chicken in Rwanda., PMID:34745207
Regulation of lipid homeostasis by the TBC protein dTBC1D22 via modulation of the small GTPase Rab40 to facilitate lipophagy., PMID:34469730
Novel Host Protein TBC1D16, a GTPase Activating Protein of Rab5C, Inhibits Prototype Foamy Virus Replication., PMID:34367131
Crystal structure of the TLDc domain of human NCOA7-AS., PMID:34341188
Downregulated genes by silencing MYC pathway identified with RNA-SEQ analysis as potential prognostic biomarkers in gastric adenocarcinoma., PMID:33351778
The Ncoa7 locus regulates V-ATPase formation and function, neurodevelopment and behaviour., PMID:33340069
Tre2-Bub2-Cdc16 Family Proteins Based Nomogram Serve as a Promising Prognosis Predicting Model for Melanoma., PMID:33194704
FgSpa2 recruits FgMsb3, a Rab8 GAP, to the polarisome to regulate polarized trafficking, growth and pathogenicity in Fusarium graminearum., PMID:32978966
Biallelic loss-of-function variants in TBC1D2B cause a neurodevelopmental disorder with seizures and gingival overgrowth., PMID:32623794
Structure of TBC1D23 N-terminus reveals a novel role for rhodanese domain., PMID:32453802
Gender-Discordant Monochorionic-Diamniotic Twins Both With 45,X/46,X, Idic(Y) Mosaicism and a Novel Deletion Within the TBC1D5 Gene., PMID:32364436
Interferon-β-induced miR-1 alleviates toxic protein accumulation by controlling autophagy., PMID:31799933
YDJC Induces Epithelial-Mesenchymal Transition via Escaping from Interaction with CDC16 through Ubiquitination of PP2A., PMID:31485224
Improved exercise capacity in cyclophilin-D knockout mice associated with enhanced oxygen utilization efficiency and augmented glucose uptake via AMPK-TBC1D1 signaling nexus., PMID:31339770
TBC1D24-TLDc-related epilepsy exercise-induced dystonia: rescue by antioxidants in a disease model., PMID:31257402
A fragment activity assay reveals the key residues of TBC1D15 GTPase-activating protein (GAP) in Chiloscyllium plagiosum., PMID:30755162
TBC1D3 regulates the payload and biological activity of extracellular vesicles that mediate tissue repair., PMID:30715917
Overexpression of Interleukin-15 exhibits improved glucose tolerance and promotes GLUT4 translocation via AMP-Activated protein kinase pathway in skeletal muscle., PMID:30654941
The epilepsy-associated protein TBC1D24 is required for normal development, survival and vesicle trafficking in mammalian neurons., PMID:30335140
Ehrlichia type IV secretion system effector Etf-2 binds to active RAB5 and delays endosome maturation., PMID:30181274
Involvement of the septation initiation network in events during cytokinesis in fission yeast., PMID:30072443
Serum Is Not Necessary for Prior Pharmacological Activation of AMPK to Increase Insulin Sensitivity of Mouse Skeletal Muscle., PMID:29662023
For research use only. Not for human or drug use.
