Catalog No.
YHG33701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg997-Ala1337
Predicted molecular weight
41.86 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q12913
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
HPTP eta, R-PTP-J, Protein-tyrosine phosphatase eta, Density-enhanced phosphatase 1, Receptor-type tyrosine-protein phosphatase eta, Protein-tyrosine phosphatase receptor type J, DEP-1, R-PTP-eta, CD148, PTPRJ, DEP1
Relieving platelet inhibition using a novel bi-specific antibody: A novel approach for circumventing the platelet storage lesion., PMID:40166144
CD148 agonistic antibody alleviates renal injury induced by chronic angiotensin II infusion in mice., PMID:40165104
Defining and Harnessing the Megakaryocyte/Platelet Checkpoint., PMID:39991916
Characterisation and hierarchy of the spermatogonial stem cell compartment in human spermatogenesis by spectral cytometry using a 16-colors panel., PMID:39725808
Dengue infection changes the expressions of CD154 and CD148 in human platelets., PMID:39710119
QM107, a novel CD148 (RTP Type J) activating peptide therapy for treating neovascular age-related macular degeneration., PMID:39428594
Ligand-induced segregation from large cell-surface phosphatases is a critical step in γδ TCR triggering., PMID:39276348
Analysis of Receptor-Type Protein Tyrosine Phosphatase Extracellular Regions with Insights from AlphaFold., PMID:38255894
CRISPR/Cas9-Mediated Modification of PTP Expression., PMID:38147207
A phosphatase-recruiting bispecific antibody-aptamer chimera for enhanced suppression of tumor growth., PMID:37170857
AKT activity orchestrates marginal zone B cell development in mice and humans., PMID:37060566
Identification of Novel Genetic Risk Factors for Focal Segmental Glomerulosclerosis in Children: Results From the Chronic Kidney Disease in Children (CKiD) Cohort., PMID:36623684
The Structure, Function and Regulation of Protein Tyrosine Phosphatase Receptor Type J and Its Role in Diseases., PMID:36611803
miR-4443 promotes radiation resistance of esophageal squamous cell carcinoma via targeting PTPRJ., PMID:36578050
Phagocytosis mediated by the human granulocyte receptor CEACAM3 is limited by the receptor-type protein tyrosine phosphatase PTPRJ., PMID:35850306
PTPRJ is downregulated in cervical squamous cell carcinoma., PMID:35791609
Integrated multiomic approach for identification of novel immunotherapeutic targets in AML., PMID:35681175
miR-204-5p promotes preeclampsia serum-induced injury in human umbilical vein endothelial cells through regulation of the PTPRJ/Notch axis., PMID:35313225
Syndecan-2 regulates PAD2 to exert antifibrotic effects on RA-ILD fibroblasts., PMID:35181688
SdrG gene activated joint surface membrane protein PTPRJ to induce periprosthetic joint infection after total hip arthroplasty., PMID:35014055
A high-resolution mass spectrometry based proteomic dataset of human regulatory T cells., PMID:34950757
Single-cell RNA sequencing deconvolutes the in vivo heterogeneity of human bone marrow-derived mesenchymal stem cells., PMID:34803492
The effects of CD148 Q276P/R326Q polymorphisms in A431D epidermoid cancer cell proliferation and epidermal growth factor receptor signaling., PMID:34791835
Acute Csk inhibition hinders B cell activation by constraining the PI3 kinase pathway., PMID:34675079
AVEXIS technology identifies novel platelet-leukocyte binding partners including CD148-CD300a., PMID:34555847
CD148 Deficiency in Fibroblasts Promotes the Development of Pulmonary Fibrosis., PMID:33784491
Changing phenotype, early clinical course and clinical predictors of inflammatory bowel disease in Sri Lanka: a retrospective, tertiary care-based, multi-centre study., PMID:33593289
The relative expression levels of CD148 and CD180 on clonal B cells and CD148/CD180 median fluorescence intensity ratios are useful in the characterization of mature B cell lymphoid neoplasms infiltrating blood and bone marrow - Results from a single centre pilot study., PMID:33455071
Candidate genes for hereditary colorectal cancer: Mutational screening and systematic review., PMID:32449991
CD148 Serves as a Prognostic Marker of Gastric Cancer and Hinders Tumor Progression by Dephosphorylating EGFR., PMID:32201537
Response to the commentary by Gholami and Amoli., PMID:32034699
Interplay between the tyrosine kinases Chk and Csk and phosphatase PTPRJ is critical for regulating platelets in mice., PMID:32016283
Agonistic anti-CD148 monoclonal antibody attenuates diabetic nephropathy in mice., PMID:31984788
Loss of PTPRJ/DEP-1 enhances NF2/Merlin-dependent meningioma development., PMID:31715329
Disrupting the transmembrane domain-mediated oligomerization of protein tyrosine phosphatase receptor J inhibits EGFR-driven cancer cell phenotypes., PMID:31676686
Recent advances in inherited platelet disorders., PMID:31348050
Comments on: "Meta-analysis of association between Arg326Gln (rs1503185) and Gln276Pro (rs1566734) polymorphisms of PTPRJ gene and cancer risk"., PMID:31301025
PTPRJ: a novel inherited thrombocytopenia gene., PMID:30898775
Cross-species genomic landscape comparison of human mucosal melanoma with canine oral and equine melanoma., PMID:30664638
Meta-analysis of association between Arg326Gln (rs1503185) and Gln276Pro (rs1566734) polymorphisms of PTPRJ gene and cancer risk., PMID:30661225
Loss-of-function mutations in PTPRJ cause a new form of inherited thrombocytopenia., PMID:30591527
The Gp1ba-Cre transgenic mouse: a new model to delineate platelet and leukocyte functions., PMID:30429161
Design, Synthesis, Biological Activity, and Structural Analysis of Lactam-Constrained PTPRJ Agonist Peptides., PMID:29888867
Genetic Complexity of Mitral Valve Prolapse Revealed by Clinical and Genetic Evaluation of a Large Family., PMID:29762926
Targeting Receptor-Type Protein Tyrosine Phosphatases with Biotherapeutics: Is Outside-in Better than Inside-Out?, PMID:29498714
Maintenance of murine platelet homeostasis by the kinase Csk and phosphatase CD148., PMID:29301754
Genetic Variability of SRC Family Kinases and Its Association with Platelet Hyperreactivity and Clinical Outcomes: A Systematic Review., PMID:29237371
Syndecan-2 Attenuates Radiation-induced Pulmonary Fibrosis and Inhibits Fibroblast Activation by Regulating PI3K/Akt/ROCK Pathway via CD148., PMID:28886261
MicroRNA-4443 regulates mast cell activation by T cell-derived microvesicles., PMID:28823811
Tumor Suppressor PTPRJ Is a Target of miR-155 in Colorectal Cancer., PMID:28316102
For research use only. Not for human or drug use.
