Catalog No.
YHG31801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Cys382-Phe573
Predicted molecular weight
24.39 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q12873
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CHD-3, Mi2-alpha, ATP-dependent helicase CHD3, Mi-2 autoantigen 240 kDa protein, Chromodomain-helicase-DNA-binding protein 3, CHD3, hZFH, Zinc finger helicase
Single-cell RNA sequencing of adult primate neocortex reveals the regulatory dynamics of neural plasticity., PMID:40385068
The potential role of chromodomain helicase DNA-binding protein 3 in defining the cervical width by regulating the early growth stage of the apical papilla during tooth development., PMID:39710094
CHD3-related Snijders Blok-Campeau syndrome with Spastic Paraplegia, Ataxia, and Situs Inversus., PMID:39709005
Insights From a Novel Splicing Variant and Recurrent Arginine Variants in the CHD3 Gene Causing Snijders Blok-Campeau Syndrome., PMID:39542866
FBW7-Mediated Degradation of CHD3 Suppresses Hepatocellular Carcinoma Metastasis and Stemness to Enhance Oxaliplatin Sensitivity., PMID:39473409
BLA1 Affects Leaf Angles by Altering Brassinosteroid Biosynthesis in Rice (Oryza sativa L.)., PMID:39207175
Novel genotypes and phenotypes in Snijders Blok-Campeau syndrome caused by CHD3 mutations., PMID:39050258
Rice CHD3/Mi-2 chromatin remodeling factor RFS regulates vascular development and root formation by modulating the transcription of auxin-related genes NAL1 and OsPIN1., PMID:39044456
Utility of genome sequencing in exome-negative pediatric patients with neurodevelopmental phenotypes., PMID:39031459
YBX1 promotes homologous recombination and resistance to platinum-induced stress in ovarian cancer by recognizing m5C modification., PMID:38880223
Comprehensive Analysis of the Expression, Prognosis, and Immune Infiltrates for Chromodomain-Helicase-DNA-Binding Proteins in Breast Tumor., PMID:38809626
A severe neurocognitive phenotype caused by biallelic CHD3 variants in two siblings., PMID:38116750
Inhibition of the chromatin remodeling factor NURF rescued sterility by a clinic variant of NuRD., PMID:37938928
PICKLE RELATED 2 is a Neofunctionalized Gene Duplicate Under Positive Selection With Antagonistic Effects to the Ancestral PICKLE Gene on the Seed Transcriptome., PMID:37931037
Snijders Blok-Campeau Syndrome: Description of 20 Additional Individuals with Variants in CHD3 and Literature Review., PMID:37761804
Pleiotropy of autism-associated chromatin regulators., PMID:37366052
De novo variants in GATAD2A in individuals with a neurodevelopmental disorder: GATAD2A-related neurodevelopmental disorder., PMID:37181331
TWIST2-mediated chromatin remodeling promotes fusion-negative rhabdomyosarcoma., PMID:37115930
De novo variants implicate chromatin modification, transcriptional regulation, and retinoic acid signaling in syndromic craniosynostosis., PMID:37086723
Novel Potential Markers of Myofibroblast Differentiation Revealed by Single-Cell RNA Sequencing Analysis of Mesenchymal Stromal Cells in Profibrotic and Adipogenic Conditions., PMID:36979822
A preliminary integrated analysis of miRNA-mRNA expression profiles reveals a role of miR-146a-3p/TRAF6 in plasma from gestational diabetes mellitus patients., PMID:36929799
A novel CHD3 variant in a patient with central precocious puberty: Expanded phenotype of Snijders Blok-Campeau syndrome?, PMID:36565043
Latency-associated upregulation of SERBP1 is important for the recruitment of transcriptional repressors to the viral major immediate early promoter of human cytomegalovirus during latent carriage., PMID:36504797
Identification of novel key genes and potential candidate small molecule drugs in diabetic kidney disease using comprehensive bioinformatics analysis., PMID:36035169
The transcriptional repressors VAL1 and VAL2 mediate genome-wide recruitment of the CHD3 chromatin remodeler PICKLE in Arabidopsis., PMID:35866997
Role of ATP-dependent chromatin remodelers in hematopoietic stem and progenitor cell maintenance., PMID:35787545
Mouse Chd4-NURD is required for neonatal spermatogonia survival and normal gonad development., PMID:35568926
Epigenetic Regulation of Immune and Inflammatory Responses in Rheumatoid Arthritis., PMID:35479077
PICKLE associates with histone deacetylase 9 to mediate vegetative phase change in Arabidopsis., PMID:35460275
Inherited variants in CHD3 show variable expressivity in Snijders Blok-Campeau syndrome., PMID:35346573
Genetic Variability of the Functional Domains of Chromodomains Helicase DNA-Binding (CHD) Proteins., PMID:34828433
Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation., PMID:34709266
Dementia subtype prediction models constructed by penalized regression methods for multiclass classification using serum microRNA expression data., PMID:34686734
Snijders Blok-Campeau syndrome caused by CHD3 gene mutation: a case report., PMID:34535214
Unique protein interaction networks define the chromatin remodelling module of the NuRD complex., PMID:34231305
Hypersociability associated with developmental delay, macrocephaly and facial dysmorphism points to CHD3 mutations., PMID:33571694
The Rice CHD3/Mi-2 Chromatin Remodeling Factor Rolled Fine Striped Promotes Flowering Independent of Photoperiod., PMID:33525623
Sequence and functional differences in the ATPase domains of CHD3 and SNF2H promise potential for selective regulability and drugability., PMID:33403747
A de novo CHD3 variant in a child with intellectual disability, autism, joint laxity, and dysmorphisms., PMID:33358638
Rare and de novo coding variants in chromodomain genes in Chiari I malformation., PMID:33352116
Locus-specific paramutation in Zea mays is maintained by a PICKLE-like chromodomain helicase DNA-binding 3 protein controlling development and male gametophyte function., PMID:33320854
A highly heterogeneous mutational pattern in POEMS syndrome., PMID:33262528
The chromatin-remodeling enzyme CHD3 plays a role in embryonic viability but is dispensable for early vascular development., PMID:32658897
A second cohort of CHD3 patients expands the molecular mechanisms known to cause Snijders Blok-Campeau syndrome., PMID:32483341
A Chromodomain-Helicase-DNA-Binding Factor Functions in Chromatin Modification and Gene Regulation., PMID:32439720
GATAD2B-associated neurodevelopmental disorder (GAND): clinical and molecular insights into a NuRD-related disorder., PMID:31949314
The NuRD complex and macrocephaly associated neurodevelopmental disorders., PMID:31737996
A Role for PICKLE in the Regulation of Cold and Salt Stress Tolerance in Arabidopsis., PMID:31354770
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism., PMID:31221981
Regulation of neuronal connectivity in the mammalian brain by chromatin remodeling., PMID:31146125
For research use only. Not for human or drug use.
