Catalog No.
YHG31501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu587-Leu858
Predicted molecular weight
33.58 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q12866
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Receptor tyrosine kinase MerTK, Proto-oncogene c-Mer, Tyrosine-protein kinase Mer, MERTK, MER
Synaptic pruning genes networks in Alzheimer's disease: correlations with neuropathology and cognitive decline., PMID:40515808
Polygenic Risk Score for Metabolic Dysfunction-Associated Steatotic Liver Disease and Steatohepatitis: A Narrative Review., PMID:40507973
EGR2 O-GlcNAcylation orchestrates the development of protumoral macrophages to limit CD8+ T cell antitumor responses., PMID:40499546
Modulation of microglial phagocytosis via the GAS6-MERTK pathway regulates pathological angiogenesis in the mouse oxygen-induced retinopathy model., PMID:40456730
Glycopolymeric Nanoparticles Block Breast Cancer Growth by Inhibiting Efferocytosis in the Tumor Microenvironment., PMID:40443825
Gpr109A in TAMs promoted hepatocellular carcinoma via increasing PKA/PPARγ/MerTK/IL-10/TGFβ induced M2c polarization., PMID:40442173
Mechanism of adipose-derived stem cell-derived extracellular vesicles affecting macrophage efferocytosis by mediating ADAM17/MerTK in the apoptosis of tubular epithelial cells after sepsis-associated acute kidney injury., PMID:40403963
Design, synthesis, and biological evaluation of novel 2-substituted aniline pyrimidine derivatives as potential and orally bioavailable Mer inhibitors with antitumor activities., PMID:40403500
Structure-Based Design of Potent and Selective MerTK Inhibitors by Modulating the Conformation of αC Helix., PMID:40391976
MerTK is Ectopically Expressed and Affects the Biological Function in Diffuse Large B-Cell Lymphoma., PMID:40387170
Single-Cell RNA-Seq Reveals Aging-Related Impairment of Microglial Efferocytosis Contributing to Apoptotic Cells Accumulation After Retinal Injury., PMID:40374315
Reprograming Model of Human Monocyte-derived Macrophages for In-vitro Assays., PMID:40323795
Impairment of endothelial MerTK accelerates atherosclerosis development., PMID:40321244
Irisin suppressed the progression of TBI via modulating AMPK/MerTK/autophagy and SYK/ROS/inflammatory signaling., PMID:40320408
Plasma proteomic profiling reveals Parkinson's disease-associated proteins: A UK Biobank study., PMID:40300504
Permanent Efferocytosis Prevention by Terminating MerTK Recycle on Tumor-Associated Macrophages for Cancer Immunotherapy., PMID:40294287
Exploring copy number variations in Lebanese families with rod-cone dystrophy reveals a novel deletion in PRPF31 with haploinsufficiency., PMID:40289750
Recent advances in TAM mechanisms in lung diseases., PMID:40287707
Sex hormone-binding globulin dampens growth and metastasis of breast cancer in an estrogen-independent manner., PMID:40241272
Host responses to S. pneumoniae in wild type and Mertk mutant mice., PMID:40238852
Xin-shu-bao tablets ameliorates ventricular remodeling against HFrEF via PPARγ/MFGE8 pathway based on MALDI-MSI and lipidomics., PMID:40216048
Discovery of Novel TYRO3/MERTK Dual Inhibitors., PMID:40215328
Paeoniflorin alleviated STZ-induced diabetic retinopathy via regulation of the PDI/ADAM17/MerTK pathway., PMID:40209310
Dexamethasone-Induced MerTK+/high M2c Macrophages Exhibit a Preference for Downregulated Gene Expression Profiles., PMID:40206211
Anti-Inflammatory Lipid Mediators from Polyunsaturated Fatty Acids: Insights into their Role in Atherosclerosis Microenvironments., PMID:40198469
Heterogeneity of Neutrophils and Immunological Function in Neonatal Sepsis: Analysis of Molecular Subtypes Based on Hypoxia-Glycolysis-Lactylation., PMID:40177399
Kupffer cell expression of macrophage receptor with collagenous structure modulates macrophage gene induction and limits acute liver injury., PMID:40117216
SIRPα modulates microglial efferocytosis and neuroinflammation following experimental subarachnoid hemorrhage via the SHP1/STAT6 axis., PMID:40108663
Interrogating mediators of single-cell transcriptional changes in the acute damaged cerebral cortex: Insights into endothelial-astrocyte interactions., PMID:40090391
Navigating TAM receptor dynamics in tumour immunotherapy., PMID:40088262
Activation of proresolving macrophages in dorsal root ganglia attenuates persistent arthritis pain., PMID:40063821
A single mutation in the PrM gene of Zika virus determines AXL dependency for infection of human neural cells., PMID:40062839
Adipose-derived stem cells attenuate rheumatoid arthritis by restoring CX3CR1+ synovial lining macrophage barrier., PMID:40038808
MERTK inhibition improves therapeutic efficacy of immune checkpoint inhibitors in hepatocellular carcinoma., PMID:40029206
Methylglyoxal deteriorates macrophage efferocytosis in diabetic wounds through ROS-induced ubiquitination degradation of KLF4., PMID:39986490
Mass cytometric analysis of circulating monocyte subsets in a murine model of diabetic gastroparesis., PMID:39947648
TLR2-Bound Cancer-Secreted Hsp70 Induces MerTK-Mediated Immunosuppression and Tumorigenesis in Solid Tumors., PMID:39941817
Restriction of Zika Virus Replication in Human Monocyte-Derived Macrophages by Pro-Inflammatory (M1) Polarization., PMID:39940721
Early-age efferocytosis directs macrophage arachidonic acid metabolism for tissue regeneration., PMID:39938482
Sulforaphane promotes diabetic wound healing by regulating macrophage efferocytosis and polarization., PMID:39938166
Immune checkpoint inhibitor induces cardiac injury by impairing efferocytosis of macrophages via MerTK cleavage., PMID:39938164
PTP Inhibition Improves the Macrophage Antitumor Immune Response and the Efficacy of Chemo- and Radiotherapy., PMID:39937118
Oxidative Stress and Energetic Failure: Common Features and Dissimilarities in 3 Different Mouse Models of Retinal Pigment Epithelium Phagocytosis Defects., PMID:39930206
Longan Aril polysaccharides ameliorate cognitive impairment in AD mice via restoration of the immune phagocytosis of microglia., PMID:39923958
Activated AXL Ameliorates Alcohol-associated Steatotic Liver Ischemia-Reperfusion Injury by Inhibiting ER stress and Mitochondria-associated Apoptosis., PMID:39897049
RNAseq of peripheral blood mononucleated cells exposed to platelet-rich fibrin and enamel matrix derivatives., PMID:39881164
Distinct TYRO3 and PROS1 expression levels contribute to preeclampsia pathogenesis., PMID:39878883
RNase T2 deficiency promotes TLR13-dependent replenishment of tissue-protective Kupffer cells., PMID:39853307
Downregulation of MerTK in circulating T cells of patients with non-proliferative diabetic retinopathy., PMID:39845889
Phytochemicals Withanolide N and Dryobalanolide as Potential Bioactive Leads for Developing Anticancer Drugs Targeting Tyrosine-Protein Kinase Mer., PMID:39792454
For research use only. Not for human or drug use.
